Detalhe da pesquisa
1.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Antimicrob Agents Chemother
; 56(8): 4161-7, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615282
2.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23021993
3.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23084906
4.
IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2.
Sci Immunol
; 7(75): eabl9943, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771946
5.
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein.
Vaccine X
; 8: 100098, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33937741
6.
P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
ChemMedChem
; 10(4): 727-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25759009
7.
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 3(4): 332-6, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900473
8.
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
ACS Med Chem Lett
; 2(3): 207-12, 2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900304
9.
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
J Med Chem
; 53(6): 2443-63, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163176
10.
Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.
J Med Chem
; 52(15): 4820-37, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19624135
11.
Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
Anal Biochem
; 342(1): 144-51, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15958191