Detalhe da pesquisa
1.
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
J Biol Chem
; 299(3): 102959, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717078
2.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418771
3.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239482
4.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562063
5.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831135
6.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett
; 14(10): 1427-1433, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849537
7.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun
; 14(1): 4812, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558654
8.
Novel and selective spiroindoline-based inhibitors of Sky kinase.
Bioorg Med Chem Lett
; 22(1): 190-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119469
9.
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett
; 22(1): 415-20, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119466
10.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089526
11.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Mol Metab
; 66: 101611, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220546
12.
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.
Bioorg Med Chem Lett
; 20(21): 6262-7, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20829042
13.
Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.
J Clin Invest
; 130(12): 6510-6522, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32853180
14.
Structural attributes influencing unbound tissue distribution.
Eur J Med Chem
; 185: 111813, 2020 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31732255
15.
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.
Bioorg Med Chem Lett
; 19(12): 3247-52, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19435665
16.
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Bioorg Med Chem
; 17(6): 2501-11, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19231206
17.
Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
ACS Med Chem Lett
; 9(5): 440-445, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795756
18.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
19.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
20.
Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).
Expert Opin Ther Pat
; 25(7): 819-30, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25828189