Pesquisa | BVS IEC

1.

STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.

Li, Juan; Williams, Matthew J; Park, Hyun Jung; Bastos, Hugo P; Wang, Xiaonan; Prins, Daniel; Wilson, Nicola K; Johnson, Carys; Sham, Kendig; Wantoch, Michelle; Watcham, Sam; Kinston, Sarah J; Pask, Dean C; Hamilton, Tina L; Sneade, Rachel; Waller, Amie K; Ghevaert, Cedric; Vassiliou, George S; Laurenti, Elisa; Kent, David G; Göttgens, Berthold; Green, Anthony R.

Blood ; 140(14): 1592-1606, 2022 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-35767701

2.

CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.

Bennett, Cavan; Lawrence, Moyra; Guerrero, Jose A; Stritt, Simon; Waller, Amie K; Yan, Yahui; Mifsud, Richard W; Ballester-Beltrán, Jose; Baig, Ayesha; Mueller, Annett; Mayer, Louisa; Warland, James; Penkett, Christopher J; Akbari, Parsa; Moreau, Thomas; Evans, Amanda L; Mookerjee, Souradip; Hoffman, Gary J; Saeb-Parsy, Kourosh; Adams, David J; Couzens, Amber L; Bender, Markus; Erber, Wendy N; Nieswandt, Bernhard; Read, Randy J; Ghevaert, Cedric.

Blood ; 139(14): 2227-2239, 2022 04 07.

Artigo em Inglês | MEDLINE | ID: mdl-35051265

3.

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.

Li, Juan; Prins, Daniel; Park, Hyun Jung; Grinfeld, Jacob; Gonzalez-Arias, Carlos; Loughran, Stephen; Dovey, Oliver M; Klampfl, Thorsten; Bennett, Cavan; Hamilton, Tina L; Pask, Dean C; Sneade, Rachel; Williams, Matthew; Aungier, Juliet; Ghevaert, Cedric; Vassiliou, George S; Kent, David G; Green, Anthony R.

Blood ; 131(6): 649-661, 2018 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-29282219

4.

Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia.

Bariana, Tadbir K; Labarque, Veerle; Heremans, Jessica; Thys, Chantal; De Reys, Mara; Greene, Daniel; Jenkins, Benjamin; Grassi, Luigi; Seyres, Denis; Burden, Frances; Whitehorn, Deborah; Shamardina, Olga; Papadia, Sofia; Gomez, Keith; BioResource, Nihr; Van Geet, Chris; Koulman, Albert; Ouwehand, Willem H; Ghevaert, Cedric; Frontini, Mattia; Turro, Ernest; Freson, Kathleen.

Haematologica ; 104(5): 1036-1045, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30467204

5.

Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice.

Tariket, Sofiane; Guerrero, Jose A; Garraud, Olivier; Ghevaert, Cedric; Cognasse, Fabrice.

Transfusion ; 59(1): 32-38, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30394544

6.

Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion.

Waller, Amie K; Lantos, Lajos; Sammut, Audrienne; Salgin, Burak; McKinney, Harriet; Foster, Holly R; Kriek, Neline; Gibbins, Jonathan M; Stanworth, Simon J; Garner, Stephen F; Venkatesh, Vidheya; Curley, Anna; Belteki, Gusztav; Ghevaert, Cedric.

Pediatr Res ; 85(6): 874-884, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30742030

7.

Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes.

Italiano, Joseph E; Bender, Markus; Merrill-Skoloff, Glenn; Ghevaert, Cedric; Nieswandt, Bernhard; Flaumenhaft, Robert.

Blood ; 138(20): 1998-2001, 2021 11 18.

Artigo em Inglês | MEDLINE | ID: mdl-34324659

8.

Circular RNA enrichment in platelets is a signature of transcriptome degradation.

Alhasan, Abd A; Izuogu, Osagie G; Al-Balool, Haya H; Steyn, Jannetta S; Evans, Amanda; Colzani, Maria; Ghevaert, Cedric; Mountford, Joanne C; Marenah, Lamin; Elliott, David J; Santibanez-Koref, Mauro; Jackson, Michael S.

Blood ; 127(9): e1-e11, 2016 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-26660425

9.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Simeoni, Ilenia; Stephens, Jonathan C; Hu, Fengyuan; Deevi, Sri V V; Megy, Karyn; Bariana, Tadbir K; Lentaigne, Claire; Schulman, Sol; Sivapalaratnam, Suthesh; Vries, Minka J A; Westbury, Sarah K; Greene, Daniel; Papadia, Sofia; Alessi, Marie-Christine; Attwood, Antony P; Ballmaier, Matthias; Baynam, Gareth; Bermejo, Emilse; Bertoli, Marta; Bray, Paul F; Bury, Loredana; Cattaneo, Marco; Collins, Peter; Daugherty, Louise C; Favier, Rémi; French, Deborah L; Furie, Bruce; Gattens, Michael; Germeshausen, Manuela; Ghevaert, Cedric; Goodeve, Anne C; Guerrero, Jose A; Hampshire, Daniel J; Hart, Daniel P; Heemskerk, Johan W M; Henskens, Yvonne M C; Hill, Marian; Hogg, Nancy; Jolley, Jennifer D; Kahr, Walter H; Kelly, Anne M; Kerr, Ron; Kostadima, Myrto; Kunishima, Shinji; Lambert, Michele P; Liesner, Ri; López, José A; Mapeta, Rutendo P; Mathias, Mary; Millar, Carolyn M.

Blood ; 127(23): 2791-803, 2016 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-27084890

10.

Brain-derived Neurotrophic Factor in Megakaryocytes.

Chacón-Fernández, Pedro; Säuberli, Katharina; Colzani, Maria; Moreau, Thomas; Ghevaert, Cedric; Barde, Yves-Alain.

J Biol Chem ; 291(19): 9872-81, 2016 May 06.

Artigo em Inglês | MEDLINE | ID: mdl-27006395

11.

Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies.

Liu, Zhi-Jian; Bussel, James B; Lakkaraja, Madhavi; Ferrer-Marin, Francisca; Ghevaert, Cedric; Feldman, Henry A; McFarland, Janice G; Chavda, Chaitanya; Sola-Visner, Martha.

Blood ; 126(10): 1234-6, 2015 Sep 03.

Artigo em Inglês | MEDLINE | ID: mdl-26209661

12.

Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy.

Eksteen, Mariana; Tiller, Heidi; Averina, Maria; Heide, Gøril; Kjaer, Mette; Ghevaert, Cedric; Michaelsen, Terje E; Ihle, Øistein; Husebekk, Anne; Skogen, Bjørn; Stuge, Tor B.

J Immunol ; 194(12): 5751-60, 2015 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-25972474

13.

Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice.

Guerrero, Jose A; Bennett, Cavan; van der Weyden, Louise; McKinney, Harriet; Chin, Melody; Nurden, Paquita; McIntyre, Zoe; Cambridge, Emma L; Estabel, Jeanne; Wardle-Jones, Hannah; Speak, Anneliese O; Erber, Wendy N; Rendon, Augusto; Ouwehand, Willem H; Ghevaert, Cedric.

Blood ; 124(24): 3624-35, 2014 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-25258341

14.

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.

Li, Juan; Kent, David G; Godfrey, Anna L; Manning, Harriet; Nangalia, Jyoti; Aziz, Athar; Chen, Edwin; Saeb-Parsy, Kourosh; Fink, Juergen; Sneade, Rachel; Hamilton, Tina L; Pask, Dean C; Silber, Yvonne; Zhao, Xiaodong; Ghevaert, Cedric; Liu, Pentao; Green, Anthony R.

Blood ; 123(20): 3139-51, 2014 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-24692758

15.

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.

Mastenbroek, Tom G; Feijge, Marion A H; Kremers, Romy M W; van den Bosch, Marion T J; Swieringa, Frauke; De Groef, Lies; Moons, Lieve; Bennett, Cavan; Ghevaert, Cedric; Johnson, Jason L; van der Meijden, Paola E J; Cosemans, Judith M E M.

Arterioscler Thromb Vasc Biol ; 35(12): 2554-61, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26471268

16.

Low-affinity FcÎ³R interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets.

Armour, Kathryn L; Smith, Cheryl S; Turner, Craig P; Kirton, Christopher M; Wilkes, Anthony M; Hadley, Andrew G; Ghevaert, Cedric; Williamson, Lorna M; Clark, Michael R.

Eur J Immunol ; 44(3): 905-14, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24285214

17.

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia.

Hobbs, Catherine M; Manning, Harriet; Bennett, Cavan; Vasquez, Louella; Severin, Sonia; Brain, Lauren; Mazharian, Alexandra; Guerrero, Jose A; Li, Juan; Soranzo, Nicole; Green, Anthony R; Watson, Steve P; Ghevaert, Cedric.

Blood ; 122(23): 3787-97, 2013 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-24085768

18.

Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers.

Ghevaert, Cedric; Herbert, Nina; Hawkins, Louise; Grehan, Nicola; Cookson, Philip; Garner, Steve F; Crisp-Hihn, Abigail; Lloyd-Evans, Paul; Evans, Amanda; Balan, Kottekkattu; Ouwehand, Willem H; Armour, Kathryn L; Clark, Mike R; Williamson, Lorna M.

Blood ; 122(3): 313-20, 2013 Jul 18.

Artigo em Inglês | MEDLINE | ID: mdl-23656729

19.

Editorial.

Ghevaert, Cedric.

Platelets ; 31(6): 691, 2020 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-32697612

20.

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.

Mazharian, Alexandra; Ghevaert, Cedric; Zhang, Lin; Massberg, Steffen; Watson, Steve P.

Blood ; 117(19): 5198-206, 2011 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-21385851

BVS IEC

Instituto Evandro Chagas

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