Detalhe da pesquisa
1.
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.
Proc Natl Acad Sci U S A
; 119(29): e2200553119, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858317
2.
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases.
Acta Neuropathol
; 147(1): 67, 2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38581586
3.
A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets.
Mol Psychiatry
; 27(5): 2590-2601, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35264729
4.
Functional imaging of brain organoids using high-density microelectrode arrays.
MRS Bull
; 47(6): 530-544, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36120104
5.
Novel ß-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Angew Chem Int Ed Engl
; 60(10): 5436-5442, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33238058
6.
Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.
Neurobiol Dis
; 121: 205-213, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30236861
7.
Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.
J Neurosci
; 34(19): 6624-33, 2014 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806687
8.
Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers.
Handb Exp Pharmacol
; 228: 99-155, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25977081
9.
Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate.
Development
; 138(8): 1459-69, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21367818
10.
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis.
Proc Natl Acad Sci U S A
; 108(14): 5807-12, 2011 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21436036
11.
Characterization of Novel Human ß-glucocerebrosidase Antibodies for Parkinson's Disease Research.
J Parkinsons Dis
; 14(1): 65-78, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38251062
12.
Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded ß-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease.
bioRxiv
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712038
13.
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice.
bioRxiv
; 2024 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352378
14.
DeePhys: A machine learning-assisted platform for electrophysiological phenotyping of human neuronal networks.
Stem Cell Reports
; 19(2): 285-298, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38278155
15.
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner.
Biochim Biophys Acta
; 1823(12): 2297-310, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22917578
16.
Characterization of Novel Human ß-glucocerebrosidase Antibodies for Parkinson Disease Research.
bioRxiv
; 2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37886493
17.
Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation.
Neuron
; 111(17): 2660-2674.e9, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37385246
18.
Targeting neuronal lysosomal dysfunction caused by ß-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Nat Commun
; 14(1): 2057, 2023 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37045813
19.
Piezo1: opening the way to preventing muscle atrophy.
J Clin Invest
; 132(10)2022 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35575087
20.
Lysosomal dysfunction in neurodegeneration: emerging concepts and methods.
Trends Neurosci
; 45(3): 184-199, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35034773