Detalhe da pesquisa
1.
Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2193866, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37013838
2.
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
Bioorg Med Chem Lett
; 68: 128718, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378251
3.
Prospect of ULK1 modulators in targeting regulatory T cells.
Bioorg Chem
; 129: 106141, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36137312
4.
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature
; 534(7605): 129-32, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251290
5.
Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure-Activity Relationship.
Molecules
; 27(23)2022 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36500529
6.
Synthesis of 7,2'-Dihydroxy-4',5'-Dimethoxyisoflavanone, a Phytoestrogen with Derma Papilla Cell Proliferative Activity.
Molecules
; 27(19)2022 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36235197
7.
Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres.
Bioorg Chem
; 107: 104521, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33334587
8.
A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones.
Int J Mol Sci
; 22(5)2021 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33803380
9.
Visible-Light-Induced Cysteine-Specific Bioconjugation: Biocompatible Thiol-Ene Click Chemistry.
Angew Chem Int Ed Engl
; 59(50): 22514-22522, 2020 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32864829
10.
Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.
Angew Chem Int Ed Engl
; 59(34): 14481-14489, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510788
11.
Asymmetric Total Synthesis of (+)-(3E)-Pinnatifidenyne via Abnormally Regioselective Pd(0)-Catalyzed Endocyclization.
J Org Chem
; 83(4): 1997-2005, 2018 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29327583
12.
Discovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase.
Org Biomol Chem
; 17(1): 186-194, 2018 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30534706
13.
Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers.
Molecules
; 23(11)2018 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463260
14.
Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions.
Molecules
; 23(9)2018 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30223428
15.
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Angew Chem Int Ed Engl
; 57(36): 11629-11633, 2018 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29978938
16.
Conformation-Enabled Total Syntheses of Ohmyungsamycinsâ A and B and Structural Revision of Ohmyungsamycinâ B.
Angew Chem Int Ed Engl
; 57(12): 3069-3073, 2018 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29380472
17.
Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism.
Biochem Biophys Res Commun
; 469(3): 580-6, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26692477
18.
A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells.
Biochem Biophys Res Commun
; 467(2): 441-6, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407844
19.
Recent Advances in the Development of Antidepressants Targeting the Purinergic P2X7 Receptor.
Curr Med Chem
; 30(2): 164-177, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35770396
20.
Risk of type 2 diabetes mellitus in adult patients with atopic dermatitis.
Diabetes Res Clin Pract
; 204: 110883, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37595846