Detalhe da pesquisa
1.
Metabolism of New Drug Modalities Research Advances - 2023 year in review.
Drug Metab Rev
; : 1-46, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38895934
2.
Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.
Drug Metab Dispos
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38834357
3.
Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism.
Mol Pharm
; 21(6): 2740-2750, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38717252
4.
Bioactivation and reactivity research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 267-300, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608698
5.
Biotransformation research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 301-342, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37737116
6.
Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.
Drug Metab Dispos
; 51(7): 862-872, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059472
7.
Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs.
Drug Metab Dispos
; 51(10): 1362-1371, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429730
8.
Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.
Drug Metab Dispos
; 51(10): 1284-1294, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37349116
9.
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Anal Chem
; 94(4): 2032-2041, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041378
10.
Biotransformation novel advances - 2021 year in review.
Drug Metab Rev
; 54(3): 207-245, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35815654
11.
Bioactivation and reactivity research advances - 2021 year in review.
Drug Metab Rev
; 54(3): 246-281, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876116
12.
Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species.
Drug Metab Dispos
; 50(3): 197-203, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34969659
13.
Novel advances in biotransformation and bioactivation research - 2020 year in review.
Drug Metab Rev
; 53(3): 384-433, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910427
14.
Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes.
Xenobiotica
; 51(1): 15-23, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32713280
15.
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica
; 51(7): 796-810, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33938357
16.
Biosynthetic Strategies for Macrocyclic Peptides.
Molecules
; 26(11)2021 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206124
17.
Novel advances in biotransformation and bioactivation research-2019 year in review.
Drug Metab Rev
; 52(3): 333-365, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645275
18.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32839277
19.
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.
Drug Metab Dispos
; 48(7): 528-536, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350063
20.
Bioactivation of α,ß-Unsaturated Carboxylic Acids Through Acyl Glucuronidation.
Drug Metab Dispos
; 48(9): 819-829, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32616543