Detalhe da pesquisa
1.
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
J Biol Chem
; 299(3): 102959, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717078
2.
NMR spectroscopy: the swiss army knife of drug discovery.
J Biomol NMR
; 74(10-11): 509-519, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32617727
3.
Structure-inspired design of ß-arrestin-biased ligands for aminergic GPCRs.
Nat Chem Biol
; 14(2): 126-134, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227473
4.
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
J Pharmacol Exp Ther
; 356(2): 410-23, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26645429
5.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett
; 24(17): 4132-40, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113930
6.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun
; 14(1): 5938, 2023 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37741852
7.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun
; 14(1): 4812, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558654
8.
Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Sci Rep
; 9(1): 6076, 2019 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967561
9.
Affinity and specificity of protein U1A-RNA complex formation based on an additive component free energy model.
J Mol Biol
; 371(5): 1405-19, 2007 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17603075
10.
Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements.
J Phys Chem B
; 112(19): 6122-30, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18293956
11.
Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Sci Rep
; 8(1): 897, 2018 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343833
12.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
13.
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
ACS Med Chem Lett
; 9(2): 68-72, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456790
14.
Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects.
ACS Chem Neurosci
; 8(1): 165-177, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27715007
15.
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 60(13): 5673-5698, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574706
16.
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J Med Chem
; 58(1): 419-32, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25353650
17.
Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies.
J Med Chem
; 56(23): 9771-9, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24219752
18.
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 61(8): 3753, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29624389
19.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22420884
20.
U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.
Biopolymers
; 95(9): 591-606, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21384338