Detalhe da pesquisa
1.
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
Nature
; 585(7823): 107-112, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32728218
2.
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Nature
; 547(7662): 222-226, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28678784
3.
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.
Nature
; 534(7607): 396-401, 2016 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281205
4.
Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3' UTRs Identified by Cellular Library Screening.
Mol Ther
; 27(4): 824-836, 2019 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30638957
5.
Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.
Nucleic Acids Res
; 44(20): 9578-9590, 2016 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27903882
6.
Generation of TCR-engineered T cells and their use to control the performance of T cell assays.
J Immunol
; 194(12): 6177-89, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25957167
7.
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.
Nucleic Acids Res
; 42(16): 10245-64, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25150148
8.
The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation.
Bioorg Med Chem Lett
; 23(13): 3753-8, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726029
9.
Formation of dsRNA by-products during in vitro transcription can be reduced by using low steady-state levels of UTP.
Front Mol Biosci
; 10: 1291045, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38146535
10.
Characterization of BNT162b2 mRNA to Evaluate Risk of Off-Target Antigen Translation.
J Pharm Sci
; 112(5): 1364-1371, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36642376
11.
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.
RNA
; 15(1): 153-75, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19029308
12.
Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics.
RNA Biol
; 8(1): 35-43, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21289486
13.
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models.
Sci Transl Med
; 13(610): eabc7804, 2021 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516826
14.
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.
Mol Biol Cell
; 17(7): 3221-31, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16687569
15.
Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond.
Wiley Interdiscip Rev RNA
; 6(5): 471-99, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061157
16.
Synthetic mRNAs with superior translation and stability properties.
Methods Mol Biol
; 969: 55-72, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23296927
17.
mRNA as a versatile tool for exogenous protein expression.
Curr Gene Ther
; 12(5): 347-61, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22827224
18.
Exploiting the mutanome for tumor vaccination.
Cancer Res
; 72(5): 1081-91, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22237626
19.
Pre-mRNA splicing in Schizosaccharomyces pombe: regulatory role of a kinase conserved from fission yeast to mammals.
Curr Genet
; 42(5): 241-51, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12589463
20.
Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.
Proc Natl Acad Sci U S A
; 99(14): 9145-9, 2002 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-12087126