Pesquisa | BVS IEC

1.

Diversification of TAM receptor tyrosine kinase function.

Zagórska, Anna; Través, Paqui G; Lew, Erin D; Dransfield, Ian; Lemke, Greg.

Nat Immunol ; 15(10): 920-8, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25194421

2.

TAM receptors regulate multiple features of microglial physiology.

Fourgeaud, Lawrence; Través, Paqui G; Tufail, Yusuf; Leal-Bailey, Humberto; Lew, Erin D; Burrola, Patrick G; Callaway, Perri; Zagórska, Anna; Rothlin, Carla V; Nimmerjahn, Axel; Lemke, Greg.

Nature ; 532(7598): 240-244, 2016 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-27049947

3.

Mutations in different components of FGF signaling in LADD syndrome.

Rohmann, Edyta; Brunner, Han G; Kayserili, Hülya; Uyguner, Oya; Nürnberg, Gudrun; Lew, Erin D; Dobbie, Angus; Eswarakumar, Veraragavan P; Uzumcu, Abdullah; Ulubil-Emeroglu, Melike; Leroy, Jules G; Li, Yun; Becker, Christian; Lehnerdt, Kai; Cremers, Cor W R J; Yüksel-Apak, Memnune; Nürnberg, Peter; Kubisch, Christian; Kubisch, Chriütian; Schlessinger, Joseph; van Bokhoven, Hans; Wollnik, Bernd.

Nat Genet ; 38(4): 414-7, 2006 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-16501574

4.

Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.

Shams, Imad; Rohmann, Edyta; Eswarakumar, Veraragavan P; Lew, Erin D; Yuzawa, Satoru; Wollnik, Bernd; Schlessinger, Joseph; Lax, Irit.

Mol Cell Biol ; 27(19): 6903-12, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17682060

5.

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.

Lew, Erin D; Bae, Jae Hyun; Rohmann, Edyta; Wollnik, Bernd; Schlessinger, Joseph.

Proc Natl Acad Sci U S A ; 104(50): 19802-7, 2007 Dec 11.

Artigo em Inglês | MEDLINE | ID: mdl-18056630

6.

Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor.

Yokoyama, Yumi; Lew, Erin D; Seelige, Ruth; Tindall, Elizabeth A; Walsh, Colin; Fagan, Patrick C; Lee, Jack Y; Nevarez, Robin; Oh, Joanne; Tucker, Kathleen D; Chen, Marissa; Diliberto, Amy; Vaaler, Heather; Smith, Kristen M; Albert, Amanda; Li, Gary; Bui, Jack D.

Cancer Res ; 79(8): 1996-2008, 2019 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-30723115

7.

A ligand for ALK.

Lemke, Greg; Lew, Erin D.

Sci Signal ; 8(360): fs2, 2015 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-25605971

8.

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

Miner, Jonathan J; Daniels, Brian P; Shrestha, Bimmi; Proenca-Modena, Jose L; Lew, Erin D; Lazear, Helen M; Gorman, Matthew J; Lemke, Greg; Klein, Robyn S; Diamond, Michael S.

Nat Med ; 21(12): 1464-72, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26523970

9.

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew, Erin D; Oh, Jennifer; Burrola, Patrick G; Lax, Irit; Zagórska, Anna; Través, Paqui G; Schlessinger, Joseph; Lemke, Greg.

Elife ; 32014 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-25265470

10.

Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.

Bhattacharyya, Suchita; Zagórska, Anna; Lew, Erin D; Shrestha, Bimmi; Rothlin, Carla V; Naughton, John; Diamond, Michael S; Lemke, Greg; Young, John A T.

Cell Host Microbe ; 14(2): 136-47, 2013 Aug 14.

Artigo em Inglês | MEDLINE | ID: mdl-23954153

11.

Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.

Burstyn-Cohen, Tal; Lew, Erin D; Través, Paqui G; Burrola, Patrick G; Hash, Joseph C; Lemke, Greg.

Neuron ; 76(6): 1123-32, 2012 Dec 20.

Artigo em Inglês | MEDLINE | ID: mdl-23259948

12.

The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.

Lew, Erin D; Furdui, Cristina M; Anderson, Karen S; Schlessinger, Joseph.

Sci Signal ; 2(58): ra6, 2009 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-19224897

13.

Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.

Furdui, Cristina M; Lew, Erin D; Schlessinger, Joseph; Anderson, Karen S.

Mol Cell ; 21(5): 711-7, 2006 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-16507368

BVS IEC

Instituto Evandro Chagas

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