Detalhe da pesquisa
1.
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature
; 534(7605): 129-32, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251290
2.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951753
3.
Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Bioorg Med Chem Lett
; 26(3): 1090-1096, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26750252
4.
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Bioorg Med Chem Lett
; 18(19): 5259-62, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18783949
5.
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
Bioorg Med Chem Lett
; 18(19): 5255-8, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18778936
6.
A Blueprint to Advance Colorectal Cancer Immunotherapies.
Cancer Immunol Res
; 5(11): 942-949, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29038296
7.
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J Med Chem
; 59(14): 6671-89, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27433829
8.
EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.
Cancer Res
; 76(6): 1591-602, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26825170
9.
Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
J Med Chem
; 57(8): 3358-68, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24678947
10.
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
J Med Chem
; 56(14): 5675-90, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23742252
11.
High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery.
Toxicol Sci
; 118(1): 71-85, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20631060
12.
NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.
J Biol Chem
; 282(19): 14253-61, 2007 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17369254
13.
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.
Bioorg Med Chem Lett
; 15(19): 4174-9, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16085414
14.
Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorg Med Chem
; 11(20): 4487-501, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129585
15.
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
Bioorg Med Chem
; 11(20): 4503-9, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129586
16.
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
Biochemistry
; 42(20): 6043-56, 2003 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12755606
17.
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Bioorg Med Chem
; 10(8): 2739-49, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12057663
18.
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).
Bioorg Med Chem Lett
; 14(14): 3721-5, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203150