Detalhe da pesquisa
1.
Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter.
Mol Microbiol
; 116(6): 1489-1511, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34738285
2.
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.
Mol Microbiol
; 116(2): 564-588, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932053
3.
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
J Antimicrob Chemother
; 75(4): 958-967, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860098
4.
Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104270
5.
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
Cell Mol Life Sci
; 73(17): 3387-400, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26973180
6.
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Mol Microbiol
; 96(4): 887-900, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25708978
7.
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
Proc Natl Acad Sci U S A
; 109(27): 10996-1001, 2012 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711816
8.
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
J Antimicrob Chemother
; 69(3): 651-63, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24235095
9.
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.
Antimicrob Agents Chemother
; 57(10): 4882-93, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23877697
10.
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei.
Front Cell Infect Microbiol
; 13: 1204707, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37475965
11.
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
Mol Pharmacol
; 80(1): 110-6, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21436312
12.
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
PLoS Negl Trop Dis
; 14(7): e0008447, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730343
13.
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
Elife
; 92020 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32762841
14.
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.
J Med Chem
; 62(6): 3021-3035, 2019 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30763102
15.
Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis.
Future Med Chem
; 11(14): 1703-1720, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31370708
16.
Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.
Int J Parasitol Drugs Drug Resist
; 9: 35-43, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30669086
17.
Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?
Mol Biochem Parasitol
; 220: 46-56, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29371154
18.
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J Med Chem
; 61(9): 3870-3888, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672041
19.
Correction to "Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model".
J Med Chem
; 64(24): 18236, 2021 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34854304
20.
Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.
PLoS Negl Trop Dis
; 10(8): e0004791, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27518185