Detalhe da pesquisa
1.
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg Med Chem Lett
; 47: 128113, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991628
2.
Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol
; 14(12): e1002584, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27935939
3.
The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J Biol Chem
; 290(32): 19681-96, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26055709
4.
Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains.
J Biol Chem
; 289(30): 20477-88, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904063
5.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem
; 66(3): 1941-1954, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719971
6.
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups.
Bioorg Med Chem Lett
; 19(3): 976-80, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095442
7.
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg Med Chem Lett
; 19(4): 1177-82, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19138846
8.
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89â Å resolution.
Acta Crystallogr F Struct Biol Commun
; 75(Pt 4): 239-245, 2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30950824
9.
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
J Med Chem
; 62(3): 1348-1361, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609350
10.
Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.
J Med Chem
; 50(18): 4453-70, 2007 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17676829
11.
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Structure
; 24(4): 502-508, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050687
12.
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J Mol Biol
; 337(2): 355-65, 2004 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15003452
13.
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J Med Chem
; 48(5): 1610-9, 2005 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15743202
14.
Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.
PLoS One
; 8(10): e77448, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24146996
15.
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
ACS Med Chem Lett
; 4(12): 1238-43, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900635
16.
Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
J Med Chem
; 55(23): 10601-9, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23137340
17.
Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
Nat Struct Mol Biol
; 17(7): 808-14, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20581824
18.
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J Med Chem
; 51(15): 4632-40, 2008 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18620382
19.
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.
Bioorg Med Chem Lett
; 17(6): 1773-8, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276055
20.
Co-crystal structure guided array synthesis of PPARgamma inverse agonists.
Bioorg Med Chem Lett
; 17(14): 3916-20, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17533125