Detalhe da pesquisa
1.
Consolidation of object recognition memory requires HRI kinase-dependent phosphorylation of eIF2α in the hippocampus.
Hippocampus
; 23(6): 431-6, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23418065
2.
Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.
Mol Pharmacol
; 79(6): 910-20, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21372172
3.
Terminating Catalytic Asymmetric Heck Cyclizations by Stereoselective Intramolecular Capture of η-Allylpalladium Intermediates: Total Synthesis of (-)-Spirotryprostatin B and Three Stereoisomers.
Tetrahedron
; 66(33): 6514-6525, 2010 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20725641
4.
Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases.
J Biomol Screen
; 14(6): 627-35, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19498081
5.
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.
Bioorg Med Chem Lett
; 19(23): 6548-51, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854648
6.
Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
ACS Omega
; 4(4): 6703-6708, 2019 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31179408
7.
Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
Bioorg Med Chem
; 16(7): 3917-25, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289861
8.
Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands.
Bioorg Med Chem Lett
; 17(24): 6905-9, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18029172
9.
Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.
Oncotarget
; 7(37): 58876-58892, 2016 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27557499
10.
Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats.
Br J Pharmacol
; 172(16): 4078-88, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25988595
11.
Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis.
Antioxid Redox Signal
; 22(15): 1295-307, 2015 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706765
12.
Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett
; 1(9): 526-9, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900242
13.
Total Synthesis of (-)-Spirotryprostatin B and Three Stereoisomers We thank NIH NIGMS (GM-30859) for financial support, Prof. A. J. Shaka and N. D. Taylor for DPFGSE experiments, Prof. H. Osada for providing spectral data for natural 1, and Prof. R. M. Williams and P. R. Sebahar for providing spectral data and a sample of synthetic ent-21. We are also grateful to Prof. R. M. Williams and Prof. S. J. Danishefsky for open exchange of information prior to publication. NMR and mass spectra were determined at UC Irvine with instruments purchased with the assistance of the NSF and NIH shared instrumentation programs.
Angew Chem Int Ed Engl
; 39(24): 4596-4599, 2000 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11169682
14.
Total synthesis of (+/-)-didehydrostemofoline (asparagamine A) and (+/-)-isodidehydrostemofoline.
J Am Chem Soc
; 125(50): 15284-5, 2003 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14664560