Pesquisa | BVS IEC

1.

Hypoxia-inducible factors in physiology and medicine.

Semenza, Gregg L.

Cell ; 148(3): 399-408, 2012 Feb 03.

Artigo em Inglês | MEDLINE | ID: mdl-22304911

2.

Serendipity, Generosity, and Inspiration.

Semenza, Gregg L.

Cell ; 167(1): 20-24, 2016 Sep 22.

Artigo em Inglês | MEDLINE | ID: mdl-27634321

3.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Luo, Weibo; Hu, Hongxia; Chang, Ryan; Zhong, Jun; Knabel, Matthew; O'Meally, Robert; Cole, Robert N; Pandey, Akhilesh; Semenza, Gregg L.

Cell ; 145(5): 732-44, 2011 May 27.

Artigo em Inglês | MEDLINE | ID: mdl-21620138

4.

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Dang, Eric V; Barbi, Joseph; Yang, Huang-Yu; Jinasena, Dilini; Yu, Hong; Zheng, Ying; Bordman, Zachary; Fu, Juan; Kim, Young; Yen, Hung-Rong; Luo, Weibo; Zeller, Karen; Shimoda, Larissa; Topalian, Suzanne L; Semenza, Gregg L; Dang, Chi V; Pardoll, Drew M; Pan, Fan.

Cell ; 146(5): 772-84, 2011 Sep 02.

Artigo em Inglês | MEDLINE | ID: mdl-21871655

5.

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations.

Semenza, Gregg L.

Annu Rev Med ; 74: 307-319, 2023 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-35773226

6.

ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.

Koyasu, Sho; Horita, Shoichiro; Saito, Keisuke; Kobayashi, Minoru; Ishikita, Hiroshi; Chow, Christalle Ct; Kambe, Gouki; Nishikawa, Shigeto; Menju, Toshi; Morinibu, Akiyo; Okochi, Yasushi; Tabuchi, Yoshiaki; Onodera, Yasuhito; Takeda, Norihiko; Date, Hiroshi; Semenza, Gregg L; Hammond, Ester M; Harada, Hiroshi.

EMBO Rep ; 24(1): e54042, 2023 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-36341521

7.

Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome.

Poll, Sarah R; Martin, Renan; Wohler, Elizabeth; Partan, Elizabeth S; Walek, Elizabeth; Salman, Shaima; Groepper, Daniel; Kratz, Lisa; Cernach, Mirlene; Jesus-Garcia, Reynaldo; Haldeman-Englert, Chad; Choi, Yoon Jae; Morris, Carol D; Cohen, Bernard; Hoover-Fong, Julie; Valle, David; Semenza, Gregg L; Sobreira, Nara L M.

PLoS Genet ; 18(12): e1010504, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36480544

8.

Targeting intratumoral hypoxia to enhance anti-tumor immunity.

Semenza, Gregg L.

Semin Cancer Biol ; 96: 5-10, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37717718

9.

Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis.

Semenza, Gregg L.

Blood ; 139(16): 2441-2449, 2022 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-34411243

10.

HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/ß-catenin pathway activation.

Liu, Xiaoxu; Xie, Peiling; Hao, Na; Zhang, Miao; Liu, Yang; Liu, Peijun; Semenza, Gregg L; He, Jianjun; Zhang, Huimin.

Proc Natl Acad Sci U S A ; 118(44)2021 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-34706936

11.

Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.

Wang, Ru; Godet, Ines; Yang, Yongkang; Salman, Shaima; Lu, Haiquan; Lyu, Yajing; Zuo, Qiaozhu; Wang, Yufeng; Zhu, Yayun; Chen, Chelsey; He, Jianjun; Gilkes, Daniele M; Semenza, Gregg L.

Proc Natl Acad Sci U S A ; 118(19)2021 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-33952697

12.

The Genomics and Genetics of Oxygen Homeostasis.

Semenza, Gregg L.

Annu Rev Genomics Hum Genet ; 21: 183-204, 2020 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-32255719

13.

O2 sensing: only skin deep?

Semenza, Gregg L.

Cell ; 133(2): 206-8, 2008 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-18423190

14.

Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors.

Semenza, Gregg L.

Physiology (Bethesda) ; 36(2): 73-83, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33595388

15.

Pharmacologic Targeting of Hypoxia-Inducible Factors.

Semenza, Gregg L.

Annu Rev Pharmacol Toxicol ; 59: 379-403, 2019 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-30625281

16.

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

Chen, Zuojia; Barbi, Joseph; Bu, Shurui; Yang, Huang-Yu; Li, Zhiyuan; Gao, Yayi; Jinasena, Dilini; Fu, Juan; Lin, Fang; Chen, Chen; Zhang, Jing; Yu, Ning; Li, Xiangpei; Shan, Zhao; Nie, Jia; Gao, Zhimei; Tian, Hong; Li, Yangyang; Yao, Zhengju; Zheng, Ying; Park, Benjamin V; Pan, Ziyi; Zhang, Jing; Dang, Eric; Li, Zhiguang; Wang, Honglin; Luo, Weibo; Li, Liwu; Semenza, Gregg L; Zheng, Song-Guo; Loser, Karin; Tsun, Andy; Greene, Mark I; Pardoll, Drew M; Pan, Fan; Li, Bin.

Immunity ; 39(2): 272-85, 2013 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-23973223

17.

HIF-1α is required for development of the sympathetic nervous system.

Bohuslavova, Romana; Cerychova, Radka; Papousek, Frantisek; Olejnickova, Veronika; Bartos, Martin; Görlach, Agnes; Kolar, Frantisek; Sedmera, David; Semenza, Gregg L; Pavlinkova, Gabriela.

Proc Natl Acad Sci U S A ; 116(27): 13414-13423, 2019 07 02.

Artigo em Inglês | MEDLINE | ID: mdl-31196952

18.

Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.

Semenza, Gregg L.

EMBO J ; 36(3): 252-259, 2017 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-28007895

19.

Heritable disorders of oxygen sensing.

Semenza, Gregg L.

Am J Med Genet A ; 185(8): 2576-2581, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33973706

20.

Heritable disorders of oxygen sensing.

Semenza, Gregg L.

Am J Med Genet A ; 185(11): 3334-3339, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34655169

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Hypoxia-inducible factors in physiology and medicine.

Serendipity, Generosity, and Inspiration.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations.

ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.

Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome.

Targeting intratumoral hypoxia to enhance anti-tumor immunity.

Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis.

HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/ß-catenin pathway activation.

Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.

The Genomics and Genetics of Oxygen Homeostasis.

O2 sensing: only skin deep?

Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors.

Pharmacologic Targeting of Hypoxia-Inducible Factors.

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

HIF-1α is required for development of the sympathetic nervous system.

Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.

Heritable disorders of oxygen sensing.

Heritable disorders of oxygen sensing.