Detalhe da pesquisa
1.
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Nat Chem Biol
; 11(11): 878-86, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26436839
2.
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.
Bioorg Med Chem Lett
; 27(21): 4838-4843, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28985999
3.
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Mol Pharmacol
; 88(6): 1011-23, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438213
4.
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Biochemistry
; 52(26): 4563-77, 2013 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23731180
5.
The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
Biochemistry
; 51(38): 7551-68, 2012 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22928782
6.
Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.
Biochemistry
; 49(33): 7151-63, 2010 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20597513
7.
Phenyltriazolinones as potent factor Xa inhibitors.
Bioorg Med Chem Lett
; 20(4): 1373-7, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20100660
8.
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Bioorg Med Chem Lett
; 19(4): 1097-100, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19167885
9.
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4441-5, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19497745
10.
Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa.
Bioorg Med Chem Lett
; 18(14): 4118-23, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550370
11.
Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.
Protein Sci
; 16(12): 2761-9, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17965184
12.
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
J Med Chem
; 50(22): 5339-56, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914785
13.
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
ACS Med Chem Lett
; 7(3): 217-22, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985301
14.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
J Med Chem
; 48(17): 5419-22, 2005 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16107141
15.
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.
J Med Chem
; 46(21): 4405-18, 2003 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14521405
16.
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
J Med Chem
; 46(25): 5298-315, 2003 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-14640539
17.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).
J Med Chem
; 45(24): 5233-48, 2002 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12431051
18.
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
ACS Med Chem Lett
; 4(12): 1238-43, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900635
19.
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2.
Protein Sci
; 17(10): 1791-7, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662907
20.
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
J Med Chem
; 51(18): 5758-65, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18800767