Detalhe da pesquisa
1.
APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.
Cell
; 187(2): 428-445.e20, 2024 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086389
2.
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Cell
; 170(4): 649-663.e13, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28802038
3.
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Cell
; 160(6): 1061-71, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728668
4.
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Nature
; 615(7953): 668-677, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890231
5.
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Immunity
; 47(3): 566-581.e9, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930663
6.
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Ann Neurol
; 89(5): 952-966, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33550655
7.
Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Hum Mol Genet
; 27(2): 211-223, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29040522
8.
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.
Proc Natl Acad Sci U S A
; 114(43): 11524-11529, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073081
9.
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.
Proc Natl Acad Sci U S A
; 113(36): 10186-91, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559087
10.
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-ß and other amyloidogenic proteins.
J Lipid Res
; 58(5): 824-836, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246336
11.
Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3ß (GSK3ß) pathway.
J Biol Chem
; 289(45): 31349-60, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25231981
12.
Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling.
EMBO J
; 29(2): 482-95, 2010 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19942860
13.
Rapid sequential clustering of NMDARs, CaMKII, and AMPARs upon activation of NMDARs at developing synapses.
Front Synaptic Neurosci
; 16: 1291262, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38660466
14.
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy.
J Exp Med
; 221(4)2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38442267
15.
Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins.
Neuron
; 112(7): 1100-1109.e5, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266643
16.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Neuron
; 112(3): 384-403.e8, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995685
17.
Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.
J Biol Chem
; 287(45): 37594-609, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22977251
18.
Chronic TREM2 activation exacerbates Aß-associated tau seeding and spreading.
J Exp Med
; 220(1)2023 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219197
19.
APOE-ε4 synergizes with sleep disruption to accelerate Aß deposition and Aß-associated tau seeding and spreading.
J Clin Invest
; 133(14)2023 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37279069
20.
Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration.
Life Sci Alliance
; 6(11)2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37562846