Detalhe da pesquisa
1.
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
J Neurosci
; 43(3): 501-521, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36639889
2.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23084906
3.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23021993
4.
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Bioorg Med Chem Lett
; 21(24): 7344-50, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22071300
5.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609585
6.
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorg Med Chem Lett
; 19(17): 5119-23, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631528
7.
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.
J Am Chem Soc
; 130(14): 4607-9, 2008 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18338894
8.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396399
9.
Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.
Bioorg Med Chem Lett
; 18(2): 716-20, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061443
10.
Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation.
Antiviral Res
; 139: 161-170, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889530
11.
Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists.
J Med Chem
; 49(4): 1231-4, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480259
12.
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.
J Med Chem
; 54(22): 7920-33, 2011 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21985673
13.
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
ACS Med Chem Lett
; 2(3): 207-12, 2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900304
14.
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
J Med Chem
; 53(6): 2443-63, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163176
15.
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
J Med Chem
; 52(22): 7163-9, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19883100
16.
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
J Med Chem
; 51(20): 6503-11, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18826204
17.
2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.
J Med Chem
; 51(13): 3946-52, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18553956
18.
Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Bioorg Med Chem Lett
; 17(11): 3006-9, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428657
19.
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.
Bioorg Med Chem Lett
; 16(10): 2595-8, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16527483
20.
Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.
Bioorg Med Chem Lett
; 14(24): 6045-8, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546726