Detalhe da pesquisa
1.
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Breast Cancer Res
; 17: 59, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25902869
2.
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
J Med Chem
; 51(12): 3388-413, 2008 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18498150
3.
Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
Anal Biochem
; 383(2): 217-25, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18801329
4.
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorg Med Chem
; 16(3): 1345-58, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17998165
5.
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
J Med Chem
; 50(6): 1380-400, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17305324
6.
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
J Med Chem
; 49(1): 135-58, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392799
7.
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
J Med Chem
; 52(14): 4400-18, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19522463
8.
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
J Med Chem
; 51(21): 6646-9, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842035