Detalhe da pesquisa
1.
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature
; 576(7786): 315-320, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776516
2.
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
PLoS Pathog
; 18(10): e1010926, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306287
3.
Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity.
Bioorg Med Chem
; 28(13): 115530, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32362386
4.
Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.
Acc Chem Res
; 50(7): 1606-1616, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636311
5.
Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
Bioorg Med Chem Lett
; 27(3): 658-661, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012840
6.
Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population.
Malar J
; 15(1): 261, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27154310
7.
Pyronaridine-artesunate Shows Promise as an Effective and Well-tolerated Treatment for Artemisinin-resistant Plasmodium falciparum Malaria.
Clin Infect Dis
; 70(10): 2196-2198, 2020 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31251323
8.
The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.
Antimicrob Agents Chemother
; 59(3): 1770-5, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534732
9.
Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.
J Antimicrob Chemother
; 69(2): 323-30, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24126794
10.
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
mBio
; 15(1): e0183223, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38059639
11.
Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.
Antimicrob Agents Chemother
; 57(12): 6196-204, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24080667
12.
The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.
Antimicrob Agents Chemother
; 57(9): 4595-8, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836177
13.
Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.
J Antimicrob Chemother
; 68(4): 786-8, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23169890
14.
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical Antimalarials.
ACS Infect Dis
; 9(3): 653-667, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802523
15.
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Sci Transl Med
; 15(686): eadc9249, 2023 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36888694
16.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Nat Commun
; 14(1): 3059, 2023 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37244916
17.
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.
Br J Pharmacol
; 180(15): 1899-1929, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197802
18.
Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.
Antimicrob Agents Chemother
; 56(2): 1105-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22123687
19.
Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine.
J Antimicrob Chemother
; 67(10): 2309-15, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22761327
20.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174