Detalhe da pesquisa
1.
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
Bioorg Med Chem Lett
; 28(4): 748-755, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29336873
2.
Large-scale prediction and testing of drug activity on side-effect targets.
Nature
; 486(7403): 361-7, 2012 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22722194
3.
The activities of drug inactive ingredients on biological targets.
Science
; 369(6502): 403-413, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32703874
4.
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.
Elife
; 62017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28786378
5.
High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.
Expert Opin Drug Metab Toxicol
; 2(6): 823-33, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125403
6.
Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.
Drug Discov Today
; 21(8): 1232-42, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27140035
7.
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Curr Top Med Chem
; 16(16): 1792-818, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26975508
8.
Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.
Drug Discov Today
; 10(21): 1421-33, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16243262
9.
Matched molecular pair analysis: significance and the impact of experimental uncertainty.
J Med Chem
; 57(9): 3786-802, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24738976
10.
A screening pattern recognition method finds new and divergent targets for drugs and natural products.
ACS Chem Biol
; 9(7): 1622-31, 2014 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24802392
11.
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.
Nat Rev Drug Discov
; 11(12): 909-22, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23197038
12.
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
J Med Chem
; 54(13): 4752-72, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21650221
13.
In vitro safety pharmacology profiling: what else beyond hERG?
Future Med Chem
; 1(4): 645-65, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21426031
14.
Mapping adverse drug reactions in chemical space.
J Med Chem
; 52(9): 3103-7, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19378990
15.
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.
J Chem Inf Model
; 49(2): 308-17, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19434832
16.
Modeling promiscuity based on in vitro safety pharmacology profiling data.
ChemMedChem
; 2(6): 874-80, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17492703
17.
Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.
ChemMedChem
; 2(6): 861-73, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17477341
18.
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.
Bioorg Med Chem
; 15(2): 903-14, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17110115
19.
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.
Bioorg Med Chem Lett
; 17(15): 4347-50, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17531480
20.
Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists.
Bioorg Med Chem Lett
; 14(10): 2451-7, 2004 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15109631