RESUMO
In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
Assuntos
Criptosporidiose/imunologia , Cryptosporidium parvum , Hipersensibilidade/imunologia , Jejuno/imunologia , Animais , Animais Recém-Nascidos , Criptosporidiose/fisiopatologia , Feminino , Hipersensibilidade/parasitologia , Hipersensibilidade/fisiopatologia , Jejuno/parasitologia , Jejuno/fisiopatologia , Ratos , Ratos Sprague-DawleyRESUMO
One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10(5) oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.