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To explore serum levels of some bone turnover markers and the involvement of the Wnt signaling in CRPS-1. Query ID="Q1" Text="Please check and confirm whether the edit made to the article title is in order." We conducted an observational study on patients with early CRPS-1 recruited before any treatment. Clinical measures were assessed together with biochemical evaluation. Values of sclerostin, DKK1, CTX-I, and P1NP were compared with sex-age-matched healthy controls (HCs). We enrolled 34 patients diagnosed with CRPS-1 (mean age 59.3 ± 10.6 years, Male/Female 10/24), median disease duration = 2 weeks (IQR 1-5); median VAS score = 76 (IQR 68-80). Foot localization was slightly more frequent than hand localization (18/16). No statistically significant difference was found between CRPS-1 patients and HCs for CTX-I (0.3 ± 0.1 ng/ml vs 0.3 ± 0.1, p = 0.140), while mean serum values of P1NP were significantly higher in CRPS-1 patients compared to HCs (70.0 ± 38.8 ng/ml vs 50.1 ± 13.6, p = 0.005). Mean levels of sclerostin and DKK1 were lower in CRPS-1 patients vs HCs (sclerostin 28.4 ± 10.8 pmol/l vs 34.1 ± 11.6, p = 0.004; DKK1 12.9 ± 10.8 pmol/l vs 24.1 ± 11.9, p = 0.001). No statistically significant difference was found for all biochemical assessments in a subgroup of fracture-induced CRPS-1. No statistically significant differences were observed according to disease localization, disease duration, presence of hyperalgesia, allodynia, sudomotor alterations, and mild or moderate/severe swelling. No significant correlation emerged between sclerostin, DKK1 levels, baseline VAS score, or McGill Pain Questionnaire score. Bone involvement in early CRPS-1 does not seem to rely on increased osteoclast activity. Conversely, a serum marker of bone formation resulted increased. Both Sclerostin and DKK1 showed decreased values, probably suggesting a widespread osteocyte loss of function.Trial registration number: Eudract Number: 2014-001156-28.
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Biomarcadores , Remodelação Óssea , Via de Sinalização Wnt , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Biomarcadores/sangue , Idoso , Remodelação Óssea/fisiologia , Via de Sinalização Wnt/fisiologia , Síndromes da Dor Regional Complexa/sangue , Síndromes da Dor Regional Complexa/metabolismo , Peptídeos e Proteínas de Sinalização Intercelular/sangue , Proteínas Adaptadoras de Transdução de Sinal/sangueRESUMO
Urban design is currently promoting the inclusion of plants in buildings. However, plants emit biogenic volatile organic compounds (BVOCs), which alone or in combination with other airborne molecules such as CO2, may result in a general increase in tropospheric pollution. Many studies have documented the effects of biotic and abiotic factors on plant BVOC responses, but few have assessed the contribution of typical CO2 levels found in indoor work and meeting spaces. To answer this question, we monitored CO2 and constitutive (MT-limonene) and induced (LOX-cis-3-hexenal) BVOC emissions of a fully developed tomato crop grown hydroponically inside an integrated rooftop greenhouse (i-RTG) in a Mediterranean climate. Two distinctive CO2 assays were performed at the level of the i-RTG by supplying or not CO2. The impact of CO2 on plant physiological emittance was then assessed, and the resulting BVOC rates were compared with reference to EU-LCI values. MT-limonene was ubiquitous among the assays and the most abundant, while LOX-cis-3-hexenal was detected only under controlled CO2 management. The highest levels detected were below the indicated LCIs and were approximately tenfold lower than the corresponding LCI for MT-limonene (50.88 vs. 5000 µg m-3) and eightfold (6.63 µg m-3) higher than the constitutive emission level for LOX-cis-3-hexenal. Over extended sampling (10 min) findings revealed a general emission decrease and significantly different CO2 concentration between the assays. Despite similar decreasing rates of predicted net photosynthesis (Pn) and stomatal conductance (gs) their correlation with decreasing CO2 under uncontrolled condition indirectly suggested a negative CO2 impact on plant emission activity. Conversely, increasing CO2 under the controlled assay showed a positive correlation with induced emissions but not with constitutive ones. Because of significantly higher levels of relative humidity registered under the uncontrolled condition, this factor was considered to affect more than CO2 the emission response and even its collection. This hypothesis was supported by literature findings and attributed to a common issue related with the sampling in static enclosure. Hence, we suggested a careful monitoring of the sampling conditions or further improvements to avoid bias and underestimation of actual emissions. Based on the main outcomes, we observed no evidence of a hazardous effect of registered CO2 rates on the BVOC emissions of tomato plant. Furthermore, because of the low BVOC levels measured in the i-RTG, we assumed as safe the recirculation of this air along building's indoor environments.
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Introduction: This study aims to examine the potential effectiveness of intravenous neridronate (IVNer) on axial involvement in patients with spondyloarthritis (SpA) refractory to non-steroidal anti-inflammatory drugs (NSAIDs) but not eligible for biological disease-modifying antirheumatic drugs (bDMARDs). Method: Patients with active SpA (BASDAI score ≥ 4) and active sacroiliitis (SI) on MRI (according to ASAS MRI definition), who were NSAID-insufficient responder/intolerant but not eligible for bDMARDs, were retrospectively recruited in a tertiary rheumatology centre between September 2015 and December 2021. IVNer (100 mg) was administered to the patients on days 1, 4, 7, and 10. Responses were evaluated 60 days after the last infusion as the median changes from the baseline of BASDAI and Visual Analogue Scale (VAS) pain and there are improvements on MRI signs. Results: A total of 38 patients (26 axial SpA, 3 enteropathic arthritis, and 9 axial psoriatic arthritis) were included [66% women, mean age ± SD: 38.0 ± 14.1 years, mean disease duration: 30.5 ± 49.5 months (range 1.0-298), 47% HLAB27+]. The reason for bDMARD ineligibility was concurrent solid tumors (n = 6) or hematological (n = 1) malignancy, comorbidities (n = 11), or patient preference (n = 20). Both median BASDAI [5.83 (4.2-8.33) versus 3.66 (1.1-6.85), p < 0.001] and VAS pain [7 (5.75-8.0) versus 3 (1.0-7.0), p < 0.0001] significantly decreased after IVNer. Of 28 available MRI at follow-up, we observed a complete (36%) or partial (39%) resolution of sacroiliitis or a persistent activity (25%). Discussion: IVNer was effective in improving axial involvement in patients with SpA refractory to NSAIDs but not eligible for bDMARDs. IVNer can be considered as a potential alternative therapeutic option in selected settings.
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Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusing on the complex interactions that occur between bone tissue's own cells and the molecular and cellular actors of the immune system, a recent and fascinating field of interest defined as osteoimmunology. Specifically, we comprehensively elaborate on the distinct pathogenic mechanisms of bone erosion seen in both rheumatoid arthritis and spondyloarthritis, as well as the characteristic process of aberrant bone formation observed in spondyloarthritis. Lastly, chronic inflammatory arthritis leads to systemic bone involvement, resulting in systemic bone loss and consequent osteoporosis, along with increased skeletal fragility.
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Objective: To evaluate in patients with rheumatoid arthritis (RA) the impact of EMA recommendations on the real-life prescription of JAK inhibitors (JAKis) and the use of the Expanded Risk Score in RA (ERS-RA) to quantify the risk of major adverse cardiac events (MACE). Methods: We conducted a retrospective analysis of real-life RA patients treated with JAKis. Patients were classified as ineligible for JAKis if they fulfilled EMA criteria (>65 years-old, history of malignancy, or increased risk of venous thromboembolic events [VTE] or MACE including smoking). Risk of MACE was defined according to ORAL Surveillance trial inclusion criteria (ORALSURV) or by using the ERS-RA. Results: Of 194 patients enrolled, 57.9% were classified as ineligible according to EMA definition (ORALSURV criteria). The most frequent reason for ineligibility was increased MACE risk (70.2%), followed by age>65 (34.2%), smoking (30.7%), and increased risk of VTE (20.2%) or malignancy (7%). The use of the ERS-RA reduced the rate of patients carrying an increased CV risk to 18.6% (p<0.001 versus ORALSURV), leading to 46.4% overall ineligible patients. Over a drug-exposure of 337 patient/years, we observed 2 VTE, one MACE (non-fatal stroke), and one solid malignancy (all in the group of patients classified as ineligible according to both the definitions). Conclusions: Rigorous application of EMA indications in clinical practice could result in the exclusion of a large proportion of RA patients from treatment with JAKis. A proper quantification of the risk for MACE by dedicated tools as ERS-RA is advocated to better tailor the management of RA.
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Artrite Reumatoide , Inibidores de Janus Quinases , Tromboembolia Venosa , Humanos , Idoso , Inibidores de Janus Quinases/efeitos adversos , Estudos Retrospectivos , Tromboembolia Venosa/epidemiologia , Tromboembolia Venosa/etiologia , Fatores de Risco , Artrite Reumatoide/tratamento farmacológico , Janus QuinasesRESUMO
Urban agriculture (UA) activities are increasing in popularity and importance due to greater food demands and reductions in agricultural land, also advocating for greater local food supply and security as well as the social and community cohesion perspective. This activity also has the potential to enhance the circularity of urban flows, repurposing nutrients from waste sources, increasing their self-sufficiency, reducing nutrient loss into the environment, and avoiding environmental cost of nutrient extraction and synthetization. The present work is aimed at defining recovery technologies outlined in the literature to obtain relevant nutrients such as N and P from waste sources in urban areas. Through literature research tools, the waste sources were defined, differentiating two main groups: (1) food, organic, biowaste and (2) wastewater. Up to 7 recovery strategies were identified for food, organic, and biowaste sources, while 11 strategies were defined for wastewater, mainly focusing on the recovery of N and P, which are applicable in UA in different forms. The potential of the recovered nutrients to cover existing and prospective UA sites was further assessed for the metropolitan area of Barcelona. Nutrient recovery from current composting and anaerobic digestion of urban sourced organic matter obtained each year in the area as well as the composting of wastewater sludge, struvite precipitation and ion exchange in wastewater effluent generated yearly in existing WWTPs were assessed. The results show that the requirements for the current and prospective UA in the area can be met 2.7 to 380.2 times for P and 1.7 to 117.5 times for N depending on the recovery strategy. While the present results are promising, current perceptions, legislation and the implementation and production costs compared to existing markets do not facilitate the application of nutrient recovery strategies, although a change is expected in the near future.
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Agricultura , Águas Residuárias , Estudos Prospectivos , Agricultura/métodos , Esgotos , FertilizaçãoRESUMO
We present an investigation of the effects on BxPC3 pancreatic cancer cells of proton therapy combined with hyperthermia, assisted by magnetic fluid hyperthermia performed with the use of magnetic nanoparticles. The cells' response to the combined treatment has been evaluated by means of the clonogenic survival assay and the estimation of DNA Double Strand Breaks (DSBs). The Reactive Oxygen Species (ROS) production, the tumor cell invasion and the cell cycle variations have also been studied. The experimental results have shown that the combination of proton therapy, MNPs administration and hyperthermia gives a clonogenic survival that is much smaller than the single irradiation treatment at all doses, thus suggesting a new effective combined therapy for the pancreatic tumor. Importantly, the effect of the therapies used here is synergistic. Moreover, after proton irradiation, the hyperthermia treatment was able to increase the number of DSBs, even though just at 6 h after the treatment. Noticeably, the magnetic nanoparticles' presence induces radiosensitization effects, and hyperthermia increases the production of ROS, which contributes to cytotoxic cellular effects and to a wide variety of lesions including DNA damage. The present study indicates a new way for clinical translation of combined therapies, also in the vision of an increasing number of hospitals that will use the proton therapy technique in the near future for different kinds of radio-resistant cancers.
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We investigated the effect of different organic coatings on the 1H-NMR relaxation properties of ultra-small iron-oxide-based magnetic nanoparticles. The first set of nanoparticles, with a magnetic core diameter ds1 = 4.4 ± 0.7 nm, was coated with polyacrylic acid (PAA) and dimercaptosuccinic acid (DMSA), while the second set, ds2 = 8.9 ± 0.9 nm, was coated with aminopropylphosphonic acid (APPA) and DMSA. At fixed core diameters but different coatings, magnetization measurements revealed a similar behavior as a function of temperature and field. On the other hand, the 1H-NMR longitudinal r1 nuclear relaxivity in the frequency range ν = 10 kHz ÷ 300 MHz displayed, for the smallest particles (diameter ds1), an intensity and a frequency behavior dependent on the kind of coating, thus indicating different electronic spin dynamics. Conversely, no differences were found in the r1 relaxivity of the biggest particles (ds2) when the coating was changed. It is concluded that, when the surface to volume ratio, i.e., the surface to bulk spins ratio, increases (smallest nanoparticles), the spin dynamics change significantly, possibly due to the contribution of surface spin dynamics/topology.
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In this perspective article, we present a short selection of some of the most significant case studies on magnetic nanoparticles for potential applications in nanomedicine, mainly magnetic resonance. For almost 10 years, our research activity focused on the comprehension of the physical mechanisms on the basis of the nuclear relaxation of magnetic nanoparticles in the presence of magnetic fields; taking advantage of the insights gathered over this time span, we report on the dependence of the relaxation behaviour on the chemico-physical properties of magnetic nanoparticles and discuss them in full detail. In particular, a critical review is carried out on the correlations between their efficiency as contrast agents in magnetic resonance imaging and the magnetic core of magnetic nanoparticles (mainly iron oxides), their size and shape, and the coating and solvent used for making them biocompatible and well dispersible in physiological media. Finally, the heuristic model proposed by Roch and coworkers is presented, as it was extensively adopted to describe most of the experimental data sets. The large amount of data analyzed allowed us to highlight both the advantages and limitations of the model.
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Urban green installations are extensively promoted to increase sustainable and accessible food production and simultaneously improve the environmental performance and liveability of city buildings. In addition to the multiple benefits of plant retrofitting, these installations may lead to a consistent increase in biogenic volatile organic compounds (BVOCs) in the urban environment, especially indoors. Accordingly, health concerns could limit the implementation of building-integrated agriculture. In a building-integrated rooftop greenhouse (i-RTG), throughout the whole hydroponic cycle, green bean emissions were dynamically collected in a static enclosure. Four representative BVOCs, α-pinene (monoterpene), ß-caryophyllene (sesquiterpene), linalool (oxygenated monoterpene) and cis-3-hexenol (LOX derivate), were investigated in the samples collected from two equivalent sections of a static enclosure, one empty and one occupied by the i-RTG plants, to estimate the volatile emission factor (EF). Throughout the season, extremely variable BVOC levels between 0.04 and 5.36 ppb were found with occasional but not significant (P > 0.05) variations between the two sections. The highest emission rates were observed during plant vegetative development, with EFs equivalent to 78.97, 75.85 and 51.34 ng g-1 h-1 for cis-3-hexenol, α-pinene, and linalool, respectively; at plant maturity, all volatiles were either close to the LLOQ (lowest limit of quantitation) or not detected. Consistent with previous studies significant relationships (r ≥ 0.92; P < 0.05) were individuated within volatiles and temperature and relative humidity of the sections. However, correlations were all negative and were mainly attributed to the relevant effect of the enclosure on the final sampling conditions. Overall, levels found were at least 15 folds lower than the given Risk and LCI values of the EU-LCI protocol for indoor environments, suggesting low BVOC exposure in the i-RTG. Statistical outcomes demonstrated the applicability of the static enclosure technique for fast BVOC emissions survey inside green retrofitted spaces. However, providing high sampling performance over entire BVOCs collection is recommended to reduce sampling error and incorrect estimation of the emissions.
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Poluentes Atmosféricos , Compostos Orgânicos Voláteis , Monoterpenos , Plantas , Compostos Orgânicos Voláteis/análiseRESUMO
African agriculture is bound to face challenges for its future food systems development and economic transformation. Indoor vertical farms with artificial lighting represent an opportunity that has been gaining relevance worldwide, thanks to their potential to enable high productivity rates, food quality and safety, year-round production, and more sustainable use of water and mineral nutrients. The present study assesses the potential for vertical farming technology integration within the African continent, targeting the countries where a more sustainable approach could be achieved. A deep analysis of each territory's major opportunities and challenges was built through an updated database of 147 development indicators from 54 African states. Countries such as South Africa, Seychelles, Egypt, Mauritius, Morocco, Tunisia, Algeria, Cape Verde, and Nigeria showed the best prospective for indoor vertical farming implementation. Moreover, Seychelles, South Africa, and Egypt resulted to be the countries where vertical indoor farming could be more sustainable.
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Agricultura , Iluminação , Fazendas , Estudos de Viabilidade , Estudos Prospectivos , MarrocosRESUMO
The City Region Food Systems approach has been proposed to achieve food system resilience and nutrition security while promoting the urgent ecological transition within urban and peri-urban areas, especially after the COVID-19 pandemic. However, the great diversity of the initiatives composing City Region Food Systems in Europe poses barriers to the assessment of their integrated sustainability. Hence, the present work is developed within the EU-H2020 project Food System in European Cities (FoodE), to build a consistent sustainability scoring system that allows comparative evaluation of City Region Food System Initiatives. Adopting a Life Cycle Thinking approach, it advances on existing knowledge and past projects, taking advantage of a participatory process, with stakeholders from multidisciplinary expertise. As a result, the research designs, and tests on 100 case studies a simplified and ready-to-use scoring mechanism based on a quali-quantitative appraisal survey tool, delivering a final sustainability score on a 1-5 points scale, to get insights on the social, economic, and environmental impacts. As in line with the needs of the UN Sustainable Development Goals, the outcome represents a step forward for the sustainable development and social innovation of food communities in cities and regions, providing a practical and empirical lens for improved planning and governance.
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Light composition modulates plant growth and defenses, thus influencing plant-pathogen interactions. We investigated the effects of different light-emitting diode (LED) red (R) (665 nm) and blue (B) (470 nm) light combinations on Actinidia chinensis performance by evaluating biometric parameters, chlorophyll a fluorescence, gas exchange and photosynthesis-related gene expression. Moreover, the influence of light on the infection by Pseudomonas syringae pv. actinidiae (Psa), the etiological agent of bacterial canker of kiwifruit, was investigated. Our study shows that 50%R-50%B (50R) and 25%R-75%B (25R) lead to the highest PSII efficiency and photosynthetic rate, but are the least effective in controlling the endophytic colonization of the host by Psa. Monochromatic red light severely reduced ΦPSII, ETR, Pn, TSS and photosynthesis-related genes expression, and both monochromatic lights lead to a reduction of DW and pigments content. Monochromatic blue light was the only treatment significantly reducing disease symptoms but did not reduce bacterial endophytic population. Our results suggest that monochromatic blue light reduces infection primarily by modulating Psa virulence more than host plant defenses.
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Actinidia , Pseudomonas syringae , Actinidia/genética , Clorofila A , Doenças das Plantas/microbiologia , VirulênciaRESUMO
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use. Thus, in order to improve the effective applicability of these materials, we studied how P407 thermogels are affected by the pH and by the inclusion of different hydrophilic polymers, used as excipients for increasing the gel stiffness. For this scope, a complete chemical-physical characterization of the synthesized gels is provided, in terms of determination of sol-gel transition temperature, viscosity and erosion degree. The data are correlated according to a statistical multivariate approach based on Principal Component Analysis and their mucoadhesion properties are also tested by Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the different P407 formulations are able to influence the release pathway of two antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate) largely used in oral diseases.
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The development of Fricke gel (FG) dosimeters based on poly(vinyl alcohol) (PVA) as the gelling agent and glutaraldehyde (GTA) as the cross-linker has enabled significant improvements in the dose response and the stability over time of spatial radiation dose distributions. However, a standard procedure for preparing FG in terms of reagent concentrations is still missing in the literature. This study aims to investigate, by means of spectrophotometric analyses, how the sensitivity to the radiation dose and the range of linearity of the dose-response curve of PVA-GTA-FG dosimeters loaded with xylenol orange sodium salt (XO) are influenced by ferrous ammonium sulphate (FAS) and XO concentrations. Moreover, the effect of different concentrations of such compounds on self-oxidation phenomena in the dosimeters was evaluated. PVA-GTA-FG dosimeters were prepared using XO concentrations in the range 0.04-0.80 mM and FAS in the range 0.05-5.00 mM. The optical absorbance properties and the dose response of FG were investigated in the interval 0.0-42.0 Gy. The results demonstrate that the amount of FAS and XO determines both the sensitivity to the absorbed dose and the interval of linearity of the dose-response curve. The study suggests that the best performances of FG dosimeters for spectrophotometric analyses can be obtained using 1.00-0.40 mM and 0.200-0.166 mM concentrations of FAS and XO, respectively.
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Osteoporosis may affect young individuals, albeit infrequently. In childhood, bone mass increases, reaching its peak between the second and third decades; then, after a period of stability, it gradually declines. Several conditions, including genetic disorders, chronic diseases, and some medications, can have an impact on bone homeostasis. Diagnosis in young patients is based on the criteria defined by the International Society for Clinical Densitometry (ISCD), published in 2013. High risk factors should be identified and monitored. Often simple interventions aimed to eliminate the underlying cause, to minimize the negative bone effects linked to drugs, or to increase calcium and vitamin D intake can protect bone mass. However, in selected cases, pharmacological treatment should be considered. Bisphosphonates remain the main therapeutic agent for children with significant skeletal fragility and are also useful in a large number of other bone conditions. Denosumab, an anti-RANKL antibody, could become a potential alternative treatment. Clinical trials to evaluate the long-term effects and safety of denosumab in children are ongoing.
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Conservadores da Densidade Óssea , Osteoporose , Densidade Óssea , Conservadores da Densidade Óssea/uso terapêutico , Criança , Denosumab/efeitos adversos , Difosfonatos/uso terapêutico , Humanos , Osteoporose/tratamento farmacológico , Osteoporose/etiologia , Fatores de RiscoRESUMO
Specialized metabolites from plants are important for human health due to their antioxidant properties. Light is one of the main factors modulating the biosynthesis of specialized metabolites, determining the cascade response activated by photoreceptors and the consequent modulation of expressed genes and biosynthetic pathways. Recent developments in light emitting diode (LED) technology have enabled improvements in artificial light applications for horticulture. In particular, the possibility to select specific spectral light compositions, intensities and photoperiods has been associated with altered metabolite content in a variety of crops. This review aims to analyze the effects of indoor LED lighting recipes and management on the specialized metabolite content in different groups of crop plants (namely medicinal and aromatic plants, microgreens and edible flowers), focusing on the literature from the last 5 years. The literature collection produced a total of 40 papers, which were analyzed according to the effects of artificial LED lighting on the content of anthocyanins, carotenoids, phenols, tocopherols, glycosides, and terpenes, and ranked on a scale of 1 to 3. Most studies applied a combination of red and blue light (22%) or monochromatic blue (23%), with a 16 h day-1 photoperiod (78%) and an intensity greater than 200 µmol m-2 s-1 (77%). These treatment features were often the most efficient in enhancing specialized metabolite content, although large variations in performance were observed, according to the species considered and the compound analyzed. The review aims to provide valuable indications for the definition of the most promising spectral components toward the achievement of nutrient-rich indoor-grown products. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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Flores/química , Folhas de Planta/química , Plantas Comestíveis/metabolismo , Plantas Medicinais/metabolismo , Verduras/efeitos da radiação , Carotenoides/química , Carotenoides/metabolismo , Produção Agrícola/instrumentação , Produção Agrícola/métodos , Flores/crescimento & desenvolvimento , Flores/metabolismo , Flores/efeitos da radiação , Luz , Fenóis/química , Fenóis/metabolismo , Folhas de Planta/crescimento & desenvolvimento , Folhas de Planta/metabolismo , Folhas de Planta/efeitos da radiação , Plantas Comestíveis/química , Plantas Comestíveis/crescimento & desenvolvimento , Plantas Comestíveis/efeitos da radiação , Plantas Medicinais/química , Plantas Medicinais/crescimento & desenvolvimento , Plantas Medicinais/efeitos da radiação , Verduras/química , Verduras/crescimento & desenvolvimento , Verduras/metabolismoRESUMO
RATIONALE: COVID-19 presentation is multifaceted and up to 44% of patients affected by COVID-19 experience musculoskeletal complaints, mostly in the form of diffuse aspecific arthromyalgias. Nevertheless, only a few cases of arthritis following SARS-CoV2 infection are reported. PATIENT CONCERNS: A 27-year-old man affected by nail psoriasis presented with monoarthritis 2 weeks after being diagnosed with COVID-19. DIAGNOSES: Diagnostic work-up and differential diagnosis were made difficult by patient isolation, absence of lab tests, and his visit via telemedicine, even though signs of first metacarpophalangeal joint involvement were clear. INTERVENTIONS: Due to the inefficacy of acetaminophen and nonsteroidal anti-inflammatory drugs, the patient was prescribed oral steroids with a rapid benefit. OUTCOMES: The patient's response to oral steroid was prompt and maintained even after therapy tapering. Even so, a formal diagnosis was not possible due to a difficult diagnostic work-up and lack of a long-term follow-up. LESSONS: Like many other viral diseases, SARS-CoV2 can play as a causative agent or as a trigger for inflammatory arthritis development in predisposed individuals.
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Artrite Reativa/virologia , COVID-19/complicações , Articulação Metacarpofalângica , Adulto , Humanos , MasculinoRESUMO
Intensive growing systems used for greenhouse tomato production, together with light interception by cladding materials or other devices, may induce intracanopy mutual shading and create suboptimal environmental conditions for plant growth. There are a large number of published peer-reviewed studies assessing the effects of supplemental light-emitting diode (LED) lighting on improving light distribution in plant canopies, increasing crop yields and producing qualitative traits. However, the research results are often contradictory, as the lighting parameters (e.g., photoperiod, intensity, and quality) and environmental conditions vary among conducted experiments. This research presents a global overview of supplemental LED lighting applications for greenhouse tomato production deepened by a meta-analysis aimed at answering the following research question: does supplemental LED lighting enhance the yield and qualitative traits of greenhouse truss tomato production? The meta-analysis was based on the differences among independent groups by comparing a control value (featuring either background solar light or solar + HPS light) with a treatment value (solar + supplemental LED light or solar + HPS + supplemental LED light, respectively) and included 31 published papers and 100 total observations. The meta-analysis results revealed the statistically significant positive effects (p-value < 0.001) of supplemental LED lighting on enhancing the yield (+40%), soluble solid (+6%) and ascorbic acid (+11%) contents, leaf chlorophyll content (+31%), photosynthetic capacity (+50%), and leaf area (+9%) compared to the control conditions. In contrast, supplemental LED lighting did not show a statistically significant effect on the leaf stomatal conductance (p-value = 0.171). In conclusion, in addition to some partial inconsistencies among the considered studies, the present research enables us to assert that supplemental LED lighting ameliorates the quantitative and qualitative aspects of greenhouse tomato production.