Four-channel optically pumped magnetometer for a magnetoencephalography sensor array.

We present a novel four-channel optically pumped magnetometer (OPM) for magnetoencephalography that utilizes a two-color pump/probe scheme on a single optical axis. We characterize its performance across 18 built sensor modules. The new sensor implements several improvements over our previously developed sensor including lower vapor-cell operating temperature, improved probe-light detection optics, and reduced optical power requirements. The sensor also has new electromagnetic field coils on the sensor head which are designed using stream-function-based current optimization. We detail the coil design methodology and present experimental characterization of the coil performance. The magnetic sensitivity of the sensor is on average 12.3 fT/rt-Hz across the 18 modules while the average gradiometrically inferred sensitivity is about 6.0 fT/rt-Hz. The sensor 3-dB bandwidth is 100 Hz on average. The on-sensor coil performance is in good agreement with the simulations.

Single-trial classification of evoked responses to auditory tones using OPM- and SQUID-MEG.

Objective.Optically pumped magnetometers (OPMs) are emerging as a near-room-temperature alternative to superconducting quantum interference devices (SQUIDs) for magnetoencephalography (MEG). In contrast to SQUIDs, OPMs can be placed in a close proximity to subject's scalp potentially increasing the signal-to-noise ratio and spatial resolution of MEG. However, experimental demonstrations of these suggested benefits are still scarce. Here, to compare a 24-channel OPM-MEG system to a commercial whole-head SQUID system in a data-driven way, we quantified their performance in classifying single-trial evoked responses.Approach.We measured evoked responses to three auditory tones in six participants using both OPM- and SQUID-MEG systems. We performed pairwise temporal classification of the single-trial responses with linear discriminant analysis as well as multiclass classification with both EEGNet convolutional neural network and xDAWN decoding.Main results.OPMs provided higher classification accuracies than SQUIDs having a similar coverage of the left hemisphere of the participant. However, the SQUID sensors covering the whole helmet had classification scores larger than those of OPMs for two of the tone pairs, demonstrating the benefits of a whole-head measurement.Significance.The results demonstrate that the current OPM-MEG system provides high-quality data about the brain with room for improvement for high bandwidth non-invasive brain-computer interfacing.

The effect of spatial sampling on the resolution of the magnetostatic inverse problem.

In magnetoencephalography, linear minimum norm inverse methods are commonly employed when a solution with minimal a priori assumptions is desirable. These methods typically produce spatially extended inverse solutions, even when the generating source is focal. Various reasons have been proposed for this effect, including intrisic properties of the minimum norm solution, effects of regularization, noise, and limitations of the sensor array. In this work, we express the lead field in terms of the magnetostatic multipole expansion and develop the minimum-norm inverse in the multipole domain. We demonstrate the close relationship between numerical regularization and explicit suppression of spatial frequencies of the magnetic field. We show that the spatial sampling capabilities of the sensor array and regularization together determine the resolution of the inverse solution. For the purposes of stabilizing the inverse estimate, we propose the multipole transformation of the lead field as an alternative or complementary means to purely numerical regularization.

Effects of head modeling errors on the spatial frequency representation of MEG.

Objectives.We aim to investigate the effects of head model inaccuracies on signal and source reconstruction accuracies for various sensor array distances to the head. This allows for the assessment of the importance of head modeling for next-generation magnetoencephalography (MEG) sensors, optically-pumped magnetometers (OPM).Approach.A 1-shell boundary element method (BEM) spherical head model with 642 vertices of radius 9 cm and conductivity of 0.33 S m-1was defined. The vertices were then randomly perturbed radially up to 2%, 4%, 6%, 8% and 10% of the radius. For each head perturbation case, the forward signal was calculated for dipolar sources located at 2 cm, 4 cm, 6 cm and 8 cm from the origin (center of the sphere), and for a 324 sensor array located at 10 cm to 15 cm from the origin. Equivalent current dipole (ECD) source localization was performed for each of these forward signals. The signal for each perturbed spherical head case was then analyzed in the spatial frequency domain, and the signal and ECD errors were quantified relative to the unperturbed case.Main results.In the noiseless and high signal-to-noise ratio (SNR) case of approximately ≥6 dB, inaccuracies in our spherical BEM head conductor models lead to increased signal and ECD inaccuracies when sensor arrays are placed closer to the head. This is true especially in the case of deep and superficial sources. In the noisy case however, the higher SNR for closer sensor arrays allows for an improved ECD fit and outweighs the effects of head geometry inaccuracies.Significance.OPMs may be placed directly on the head, as opposed to the more commonly used superconducting quantum interference device sensors which must be placed a few centimeters away from the head. OPMs thus allow for signals of higher spatial resolution to be captured, resulting in potentially more accurate source localizations. Our results suggest that an increased emphasis on accurate head modeling for OPMs may be necessary to fully realize its improved source localization potential.

A Four-channel Optically Pumped Magnetometer for a Magnetoencephalography Sensor Array.

We present a novel four-channel OPM sensor for magnetoencephalography that utilizes a two-color pump/probe scheme on a single optical axis. We characterize its performance across 18 built sensor modules. The new sensor implements several improvements over our previously developed sensor including lower vapor-cell operating temperature, improved probe-light detection optics, and reduced optical power requirements. The sensor also has new electromagnetic field coils on the sensor head which are designed using stream-function-based current optimization. We detail the coil design methodology and present experimental characterization of the coil performance. The magnetic sensitivity of the sensor is on average 12.3 fT/rt-Hz across the 18 modules while the average gradiometrically inferred sensitivity is about 6.0 fT/rt-Hz. The sensor 3-dB bandwidth is 100 Hz on average. The on-sensor coil performance is in good agreement with the simulations.

A compact cold-atom interferometer with a high data-rate grating magneto-optical trap and a photonic-integrated-circuit-compatible laser system.

The extreme miniaturization of a cold-atom interferometer accelerometer requires the development of novel technologies and architectures for the interferometer subsystems. Here, we describe several component technologies and a laser system architecture to enable a path to such miniaturization. We developed a custom, compact titanium vacuum package containing a microfabricated grating chip for a tetrahedral grating magneto-optical trap (GMOT) using a single cooling beam. In addition, we designed a multi-channel photonic-integrated-circuit-compatible laser system implemented with a single seed laser and single sideband modulators in a time-multiplexed manner, reducing the number of optical channels connected to the sensor head. In a compact sensor head containing the vacuum package, sub-Doppler cooling in the GMOT produces 15 µK temperatures, and the GMOT can operate at a 20 Hz data rate. We validated the atomic coherence with Ramsey interferometry using microwave spectroscopy, then demonstrated a light-pulse atom interferometer in a gravimeter configuration for a 10 Hz measurement data rate and T = 0-4.5 ms interrogation time, resulting in Δg/g = 2.0 × 10-6. This work represents a significant step towards deployable cold-atom inertial sensors under large amplitude motional dynamics.

Gradient Field Detection Using Interference of Stimulated Microwave Optical Sidebands.

We demonstrate that stimulated microwave optical sideband generation using parametric frequency conversion can be utilized as a powerful technique for coherent state detection in atomic physics experiments. The technique has advantages over traditional absorption or polarization rotation-based measurements and enables the isolation of signal photons from probe photons. We outline a theoretical framework that accurately models sideband generation using a density matrix formalism. Using this technique, we demonstrate a novel intrinsic magnetic gradiometer that detects magnetic gradient fields between two spatially separated vapor cells by measuring the frequency of the beat note between sidebands generated within each cell. The sidebands are produced with high efficiency using parametric frequency conversion of a probe beam interacting with ^{87}Rb atoms in a coherent superposition of magnetically sensitive hyperfine ground states. Interference between the sidebands generates a low-frequency beat note whose frequency is determined by the magnetic field gradient between the two vapor cells. In contrast to traditional gradiometers the intermediate step of measuring the magnetic field experienced by the two vapor cells is unnecessary. We show that this technique can be readily implemented in a practical device by demonstrating a compact magnetic gradiometer sensor head with a sensitivity of 25 fT/cm/sqrt[Hz] with a 4.4 cm baseline, while operating in a noisy laboratory environment unshielded from Earth's field.

Calibration and Localization of Optically Pumped Magnetometers Using Electromagnetic Coils.

In this paper, we propose a method to estimate the position, orientation, and gain of a magnetic field sensor using a set of (large) electromagnetic coils. We apply the method for calibrating an array of optically pumped magnetometers (OPMs) for magnetoencephalography (MEG). We first measure the magnetic fields of the coils at multiple known positions using a well-calibrated triaxial magnetometer, and model these discreetly sampled fields using vector spherical harmonics (VSH) functions. We then localize and calibrate an OPM by minimizing the sum of squared errors between the model signals and the OPM responses to the coil fields. We show that by using homogeneous and first-order gradient fields, the OPM sensor parameters (gain, position, and orientation) can be obtained from a set of linear equations with pseudo-inverses of two matrices. The currents that should be applied to the coils for approximating these low-order field components can be determined based on the VSH models. Computationally simple initial estimates of the OPM sensor parameters follow. As a first test of the method, we placed a fluxgate magnetometer at multiple positions and estimated the RMS position, orientation, and gain errors of the method to be 1.0 mm, 0.2°, and 0.8%, respectively. Lastly, we calibrated a 48-channel OPM array. The accuracy of the OPM calibration was tested by using the OPM array to localize magnetic dipoles in a phantom, which resulted in an average dipole position error of 3.3 mm. The results demonstrate the feasibility of using electromagnetic coils to calibrate and localize OPMs for MEG.

Cross-Axis projection error in optically pumped magnetometers and its implication for magnetoencephalography systems.

Optically pumped magnetometers (OPMs) developed for magnetoencephalography (MEG) typically operate in the spin-exchange-relaxation-free (SERF) regime and measure a magnetic field component perpendicular to the propagation axis of the optical-pumping photons. The most common type of OPM for MEG employs alkali atoms, e.g. 87Rb, as the sensing element and one or more lasers for preparation and interrogation of the magnetically sensitive states of the alkali atoms ensemble. The sensitivity of the OPM can be greatly enhanced by operating it in the SERF regime, where the alkali atoms' spin exchange rate is much faster than the Larmor precession frequency. The SERF regime accommodates remnant static magnetic fields up to ±5 nT. However, in the presented work, through simulation and experiment, we demonstrate that multi-axis magnetic signals in the presence of small remnant static magnetic fields, not violating the SERF criteria, can introduce significant error terms in OPM's output signal. We call these deterministic errors cross-axis projection errors (CAPE), where magnetic field components of the MEG signal perpendicular to the nominal sensing axis contribute to the OPM signal giving rise to substantial amplitude and phase errors. Furthermore, through simulation, we have discovered that CAPE can degrade localization and calibration accuracy of OPM-based magnetoencephalography (OPM-MEG) systems.

Magnetometers vs Gradiometers for Neural Speech Decoding.

Neural speech decoding aims at providing natural rate communication assistance to patients with locked-in state (e.g. due to amyotrophic lateral sclerosis, ALS) in contrast to the traditional brain-computer interface (BCI) spellers which are slow. Recent studies have shown that Magnetoencephalography (MEG) is a suitable neuroimaging modality to study neural speech decoding considering its excellent temporal resolution that can characterize the fast dynamics of speech. Gradiometers have been the preferred choice for sensor space analysis with MEG, due to their efficacy in noise suppression over magnetometers. However, recent development of optically pumped magnetometers (OPM) based wearable-MEG devices have shown great potential in future BCI applications, yet, no prior study has evaluated the performance of magnetometers in neural speech decoding. In this study, we decoded imagined and spoken speech from the MEG signals of seven healthy participants and compared the performance of magnetometers and gradiometers. Experimental results indicated that magnetometers also have the potential for neural speech decoding, although the performance was significantly lower than that obtained with gradiometers. Further, we implemented a wavelet based denoising strategy that improved the performance of both magnetometers and gradiometers significantly. These findings reconfirm that gradiometers are preferable in MEG based decoding analysis but also provide the possibility towards the use of magnetometers (or OPMs) for the development of the next-generation speech-BCIs.

Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System.

A non-invasive functional-brain-imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject's scalp. We have conducted two MEG experiments on three subjects: assessment of somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial MEG system based on superconducting quantum interference devices (SQUIDs). We cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects. Due to the proximity (12 mm) of the OPM channels to the scalp, it is anticipated that future OPM-based MEG systems will offer enhanced spatial resolution as they will capture finer spatial features compared to traditional MEG systems employing SQUIDs.

Magnetic Source Imaging Using a Pulsed Optically Pumped Magnetometer Array.

We have developed a pulsed optically pumped magnetometer (OPM) array for detecting magnetic field maps originated from an arbitrary current distribution. The presented magnetic source imaging (MSI) system features 24 OPM channels, has a data rate of 500 S/s, a sensitivity of 0.8 p T / H z , and a dynamic range of 72 dB. We have employed our pulsed- OPM MSI system for measuring the magnetic field map of a test coil structure. The coils are moved across the array in an indexed fashion to measure the magnetic field over an area larger than the array. The captured magnetic field maps show excellent agreement with the simulation results. Assuming a 2D current distribution, we have solved the inverse problem, using the measured magnetic field maps, and the reconstructed current distribution image is compared to that of the simulation.

A 20-channel magnetoencephalography system based on optically pumped magnetometers.

We describe a multichannel magnetoencephalography (MEG) system that uses optically pumped magnetometers (OPMs) to sense the magnetic fields of the human brain. The system consists of an array of 20 OPM channels conforming to the human subject's head, a person-sized magnetic shield containing the array and the human subject, a laser system to drive the OPM array, and various control and data acquisition systems. We conducted two MEG experiments: auditory evoked magnetic field and somatosensory evoked magnetic field, on three healthy male subjects, using both our OPM array and a 306-channel Elekta-Neuromag superconducting quantum interference device (SQUID) MEG system. The described OPM array measures the tangential components of the magnetic field as opposed to the radial component measured by most SQUID-based MEG systems. Herein, we compare the results of the OPM- and SQUID-based MEG systems on the auditory and somatosensory data recorded in the same individuals on both systems.

Four-channel optically pumped atomic magnetometer for magnetoencephalography.

We have developed a four-channel optically pumped atomic magnetometer for magnetoencephalography (MEG) that incorporates a passive diffractive optical element (DOE). The DOE allows us to achieve a long, 18-mm gradiometer baseline in a compact footprint on the head. Using gradiometry, the sensitivities of the channels are < 5 fT/Hz1/2, and the 3-dB bandwidths are approximately 90 Hz, which are both sufficient to perform MEG. Additionally, the channels are highly uniform, which offers the possibility of employing standard MEG post-processing techniques. This module will serve as a building block of an array for magnetic source localization.

A highly miniaturized vacuum package for a trapped ion atomic clock.

We report on the development of a highly miniaturized vacuum package for use in an atomic clock utilizing trapped ytterbium-171 ions. The vacuum package is approximately 1 cm(3) in size and contains a linear quadrupole RF Paul ion trap, miniature neutral Yb sources, and a non-evaporable getter pump. We describe the fabrication process for making the Yb sources and assembling the vacuum package. To prepare the vacuum package for ion trapping, it was evacuated, baked at a high temperature, and then back filled with a helium buffer gas. Once appropriate vacuum conditions were achieved in the package, it was sealed with a copper pinch-off and was subsequently pumped only by the non-evaporable getter. We demonstrated ion trapping in this vacuum package and the operation of an atomic clock, stabilizing a local oscillator to the 12.6 GHz hyperfine transition of (171)Y b(+). The fractional frequency stability of the clock was measured to be 2 × 10(-11)/τ(1/2).

In situ dissolution or deposition of Ytterbium (Yb) metal in microhotplate wells for a miniaturized atomic clock.

Current atomic clocks are burdened by size, weight, power and portability limitations to satisfy a broad range of potential applications. One critical need in the fabrication of a miniaturized atomic clock is small, low-power metallic sources. Exploiting the relatively high vapor pressure of ytterbium (Yb) and its dissolution in anhydrous ammonia, we report two independent techniques for depositing Yb inside a well micromachined into a microhotplate. Subsequent in situ evaporation of Yb from the microhotplate well serves as a low-power metallic source suitable for atomic clocks. The deposition and evaporation of Yb were confirmed using a variety of physicochemical techniques including quartz crystal microbalance, scanning electron microscopy, energy dispersive X-ray spectroscopy, and laser fluorescence. We also describe the fabrication of the microhotplate device, an integral component of our Yb-based miniature atomic clock. The Yb deposition/evaporation on a microhotplate well is thus useful as a low power Yb source during the fabrication of a miniaturized atomic clock, and this technique could be used for other applications requiring a vapor of a metal that has a moderate vapor pressure.

Magnetic Relaxometry with an Atomic Magnetometer and SQUID Sensors on Targeted Cancer Cells.

Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting Quantum Interference Device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capabilities of detecting fewer than 100,000 magnetically-labeled cancer cells. The emerging technology of atomic magnetometers (AM) represents a new detection method for magnetic relaxometry with high sensitivity and without the requirement for cryogens. We report here on a study of magnetic relaxometry using both AM and SQUID sensors to detect cancer cells that are coated with superparamagnetic nanoparticles through antibody targeting. The AM studies conform closely to SQUID sensor results in the measurement of the magnetic decay characteristics following a magnetization pulse. The AM and SQUID sensor data are well described theoretically for superparamagnetic particles bound to cells and the results can be used to determine the number of cells in a cell culture or tumor. The observed fields and magnetic moments of cancer cells are linear with the number of cells over a very large range. The AM sensor demonstrates very high sensitivity for detecting magnetically labeled cells does not require cryogenic cooling and is relatively inexpensive.