[Amizon in the treatment of nervous system involvement in herpes zoster]. / Amizon v lechenii porazhenii nervnoi sistemy pri opoiasyvaiushchem gerpese.

The authors submit results of treatment of patients having suffered from postherpetic pain syndrome (herpetic ganglionitis of the cervical, thoracic, lumbosacral localization, postherpetic intercostal neuralgia, ganglionitis of the trigeminal nerve). In viral diseases, amizone has marked analgetic, antiinflammatory, and immunomodulating effects. The drug is well tolerated by patients, is not associated with side effects under prescribed doses (0.25-0.75 as one dose on a three- or four-times daily schedule during the course of treatment lasting three or four weeks). The drug preparation in question is less effective in the treatment of chronic recurring post-therapeutic intercostal neuralgias, radiculalgia.

[Anticyan--a new highly effective antidote in cyanide poisoning]. / Antitsian--novyi vysokoéffektivnyi antidot pri otravlenii tsianidami.

Anticyan is a highly effective antidote of cyanic acid and cyanide-containing compounds. It was created at the Institute of Pharmacology and Toxicology of AMS of Ukraine. Anticyan differs from other existing cyanide antidotes in that it possesses a tready methemoglobin-formation activity, has no hypotensive effect and is capable of direct stimulation of cyanide-inhibited tissue respiration.

[The prospects and problems of drug-induced anesthesia]. / Perspektivy i problemy lekarstvennogo obezbolivaniia.

The problem of pain has a major medico-social significance and necessitates detailed investigation both from the position of etiology and pathogenesis and new therapy methods. Among many methods of pain control drug-induced anesthesia is of great importance. The multiplicity of pain requires optimal use of analgetics and their combination with other agents strictly in coordination with individual needs of the patient. Special anesthesia systems are to be designed for this purpose.

[Analysis of the role of calcium in analgesic action of non-narcotic analgesics and calcium channel blockers]. / Analiz roli kal'tsiia v obezbolivaiushchem deistvii nenarkoticheskikh anal'getikov i blokatorov kal'tsievykh kanalov.

In the mice hot-plate test we have compared analgesic effect of calcium channel blockers and new non-narcotic analgesic antiinflammatory agent PV-107: verapamil > fenigidin > PV-107. Simultaneously we have shown strong correlation (r - 0.82) between analgesic effect and 45Ca2+ efflux of cardiac membrane in depolarizing media in vitro.

[Experimental morphological study of the effect of liposomes in CCl4 poisoning]. / Eksperimental'no-morfologicheskoe izuchenie vliianiia liposom pri intoksikatsii CCl4.

The experiments on white mice have shown CCl4 to induce 24 hours after its injection focal changes in the liver, such as hepatocyte necrotization accompanied by lell organoid destruction, drastic reduction in glycogen content and increased fat content, as well as considerable decline in the activity of aerobic and anaerobic metabolic enzymes. Liposome administration attenuated the lytic effect of poison, promoting the integrity of subcellular hepatocyte structures. Distrophic changes in the latter led to increased glycogen content lower lipid level and intensified bioenergic processes.

[Changes in the secondary and tertiary structure of serum albumin in interactions with ligands of various structures]. / Izmeneniia vtorichnoi i tretichnoi struktury syvorotochnogo al'bumina pri vzaimodeistvii s ligandami razlichnogo stroeniia.

High affinity interactions between blood serum albumin and five substances of various chemical structure, exhibiting distinct physiological activity, were accompanied by alterations in the protein tertiary structure, while the albumin secondary structure was involved in conformational transformation after less effective affinity binding.

[Penetration and binding strength of cadmium and its complexes with dithiols in cells]. / Proniknovenie i prochnost' sviazyvaniia kadmiia i ego kompleksov s ditiolami v kletkakh.

It was shown in experiments with three types of cells (dog red cells, hepatic cells of newborn Wistar rats, and culture of the renal epithelium of Vero monkeys) that cadmium in complexes with dimercaptoethanol penetrates the cells in an 8-33-fold greater amounts than free cations of metal. Unithiol increases cadmium penetration in the cells by 1.6-3 times only. The strength of cadmium binding with dimercaptopropranolol in the cells is greater than that with unithiol and free cations. Albumin limits penetration of free cations of cadmium and of complexes with dimercaptothiol to a greater degree than that of cadmium complexes with unithiols. The reasons for the differences revealed are discussed.

[Thiol compounds in the combined therapy of prozerin poisonings]. / Tiolovye soedineniia v kombinirovannoi terapii otravlenii prozerinom.

The authors studied the protective action of dithiols (unithiol, dithiothreitol) and their combinations with atropine in proserine poisoning. With the use of the spatial-prospective plotting the antidote efficacy of dipyroxime, atropine, dithiothreitole, and their combinations was studied and compared. A new type of potentiation was discovered upon combined use of atropine, dipyroxime and dithiothreitol.

[Noncholinesterase component in the molecular mechanism of action of the cholinesterase reactivator dipyroxime]. / Nekholinésteraznyi komponent v molekuliarnom mekhanizme deistviia reaktivatora kholinésterazy dipiroksima.

While changing the structure of the superficial layers of the serum albumin molecule, the cholinesterase reactivator dipyroxime increases the protein binding capacity as regards the organophosphorus poison dimethyldichlorovinyl phosphate. This may be conductive to the reduction of the latter's acute toxicity.

[Mefenaminic acid binding by blood plasma and organ homogenates]. / Sviazyvanie mefenaminovoi kisloty plazmoi krovi i gomogenatami organov.

Concerns the spectrophotometric method for microdetermination of total and unbound mefenaminic acid in biological material. The method has been developed on the basis of stained complex formation. Mefenaminic acid binding to plasma proteins and organ homogenates has been studied in vitro and in vivo experiments and by the methods of equilibrium dialysis and fluorescence. The rate of drug binding to plasma proteins amounts to 75 +/- 5%. The highest binding capacity is shown by the plasma, liver and kidneys. In the plasma, mefenaminic acid is chiefly bound to albumin in whose molecule there have been established two monotypic sites of binding with an association constant of approximately (1.23-1.68) . 10(5) M-1. In vivo experiments show variations in the relative indices of plasma bound mefenaminic acid as dependent on the dose and route of administration. In vitro evidence correlates with the results obtained in experiments made in vivo.

[Pharmacological properties and antitumor activity of a preparation diiodo-benzo-tepa in experiments]. / Farmakologicheskie svoistva i protivoopukholevaia aktivnost' preparata diiodbenzotef v eksperimente.

Experimental data on the pharmacokinetics, toxicity, antitumor activity of the antitumor drug diiodo-benzo-TEPA are reported.