Passive Exoskeletons During Live Surgeries: Supporting Forward Head Postures Among Veterinary Surgeons.

TECHNICAL ABSTRACTBackground: Musculoskeletal symptoms (MSS) are prevalent among veterinary surgeons. Recent research has proposed exoskeletons as potential solutions in reducing the risk of musculoskeletal disorders among surgeons, but no studies have addressed the neck forward postures (opposite of overhead work), a unique ergonomic neck risk, commonly required during live, open surgery. Purpose: We explored the effectiveness of a passive neck-support exoskeleton during live veterinary surgical procedures with experienced surgeons. Methods: We employed a within-subject crossover design involving surgeons who participated in procedures across specialties including soft tissue and orthopedics. Participants performed entire surgeries with and without a front head posture support prototype exoskeleton, and they completed pre- and post-surgical surveys to assess MSS and perceived effort. The Wilcoxon Signed Rank Test was used to compare median values of MSS and the perceived effort of each participant when they operated with and without the exoskeleton. Results: We collected data during 28 procedures involving eight surgeons, with each subject performing at least one surgery with (intervention) and at least one surgery without (control) the exoskeleton (randomized order). The number of control and intervention cases for each participant was balanced. We found that the difference in neck stiffness before and after surgery was greater in the control surgeries compared to when using the exoskeleton intervention. Increases in neck pain and neck stiffness were only observed in control cases, whereas no participant reported increased neck pain or neck stiffness when the exoskeleton was used. Conclusion: Our results indicate that a passive forward head posture support exoskeleton is a promising intervention for reducing the risk of MSS in live surgical procedures.

Surgeons, including veterinary surgeons, are exposed to many ergonomic challenges due to their work settings. The prolonged, sustained neck flexion necessary during surgeries can lead to muscle fatigue and discomfort, potentially causing musculoskeletal disorders. Our research explored the use of a passive exoskeleton to provide support for forward head posture (FHP) during live veterinary surgeries in the field. Our findings indicate that the passive FHP support exoskeleton can potentially reduce musculoskeletal symptoms among surgeons. Further studies, though, are needed to continue generating biomechanical evidence to objectively assess the effectiveness of the exoskeleton in prolonged use.

Asymmetric and Flexible Ag-MXene/ANFs Composite Papers for Electromagnetic Shielding and Thermal Management.

Lightweight, flexible, and electrically conductive thin films with high electromagnetic interference (EMI) shielding effectiveness and excellent thermal management capability are ideal for portable and flexible electronic devices. Herein, the asymmetric and multilayered structure Ag-MXene/ANFs composite papers (AMAGM) were fabricated based on Ag-MXene hybrids and aramid nanofibers (ANFs) via a self-reduction and alternating vacuum-assisted filtration process. The resultant AMAGM composite papers exhibit high electrical conductivity of 248,120 S m-1, excellent mechanical properties with tensile strength of 124.21 MPa and fracture strain of 4.98%, superior EMI shielding effectiveness (62 dB), ultra-high EMI SE/t (11,923 dB cm2 g-1) and outstanding EMI SE reliability as high as 96.1% even after 5000 cycles of bending deformation benefiting from the unique structure and the 3D network at a thickness of 34 µm. Asymmetric structures play an important role in regulating reflection and absorption of electromagnetic waves. In addition, the multifunctional nanocomposite papers reveal outstanding thermal management performances such as ultrafast thermal response, high heating temperatures at low operation voltage, and high heating stability. The results indicate that the AMAGM composite papers have excellent potential for high-integration electromagnetic shielding, wearable electronics, artificial intelligence, and high-performance heating devices.

Enhanced performance of hybrid supercapacitors by the synergistic effect of Co(OH)2 nanosheets and NiMn layered hydroxides.

A self-supporting composite electrode material with a unique three-dimensional structure was synthesized by in-situ growth of nanoscale NiMnLDH-Co(OH)2 on a nickel foam substrate via hydrothermal electrodeposition. The 3D layer of NiMnLDH-Co(OH)2 provided abundant reactive sites for electrochemical reactions, ensuring a solid and conductive skeleton for charge transfer and resulting in significant enhancement of electrochemical performance. The composite material showed a strong synergistic effect between the small nano-sheet Co(OH)2 and NiMnLDH, which promoted reaction kinetics, while the nickel foam substrate acted as a structural conductivity agent, stabilizer, and good conductive medium. The composite electrode showed impressive electrochemical performance, achieving a specific capacitance of 1870F g-1 at 1 A g-1 and retaining 87% capacitance after 3000 charge-discharge cycles, even at a high current density of 10 A g-1. Moreover, the resulting NiMnLDH-Co(OH)2//AC asymmetric supercapacitor (ASC) demonstrated remarkable specific energy of 58.2 Wh kg-1 at a specific power of 1200 W kg-1, along with outstanding cycle stability (89% capacitance retention after 5000 cycles at 10 A g-1). More importantly, DFT calculations reveal that NiMnLDH-Co(OH)2 facilitates charge transfer, accelerating surface redox reactions and increasing specific capacitance. This study presents a promising approach towards designing and developing advanced electrode materials for high-performance supercapacitors.

Spatial correlation network characteristics of embodied carbon transfer in global agricultural trade.

Agricultural carbon emission is an important cause of climate change, and the carbon transfer caused by agricultural trade is a key area related to carbon emissions of all countries. Based on the Eora database, this paper aims to constructs a multi-region input-output database of 185 countries or regions, analyzes a spatial correlation network of embodied net carbon transfer in global agricultural trade by using UCINET, selects multi-dimensional network measurement indicators, and comprehensively studies the global evolution characteristics and functional features of network plate role of embodied carbon transfer in the global agricultural trade. The result shows that the embodied net carbon transfer network of global agricultural trade is densely connected, the spatial correlation spillover effect is significant, and the edge of the network core structure is clear. On the one hand, the top four countries or regions in terms of embodied carbon outflow in agricultural trade are the USA, Australia, Vietnam, and China. On the other hand, the top four countries or regions of embodied carbon inflow are Malaysia, Central Africa, Singapore, and Serbia. From the perspective of outdegree, indegree, proximity centrality, and intermediary centrality, Cambodia, the Netherlands, Vietnam, Ghana, and South Africa, with the high frequency of the shortest path of the globally embodied net carbon transfer network, have a strong influence and linking facility in spatial correlation and have a strong control ability to the spatial correlation of other countries or regions. The embodied carbon emission network of global agricultural trade can be divided into four sectors: main spillover, two-way spillover, broker, and main benefit. The main spillover segment, constituted by the USA, India, Germany, and China, has significant embodied carbon spillover effects on the internal segment and other segments. It is the main embodied carbon spillover sector of embodied net carbon transfer of global agricultural trade. Countries should reasonably allocate the responsibility of carbon reduction according to the trading embodied carbon transfer and made efforts to optimize the export structure of agricultural products.

Trade and Embodied CO2 Emissions: Analysis from a Global Input-Output Perspective.

Global trade drives the world's economic development, while a large amount of embodied carbon is transferred among different countries and regions. Based on a multi-regional input-output model, the trade embodied carbon transfers of bilateral trade between 185 countries/regions around the world were calculated. On the basis, regional trade embodied carbon transfer patterns and major national trade patterns in six continents, eight major economic cooperation organizations, and six representative countries/regions were further analyzed. The results showed that Europe was the continent with the largest embodied carbon inflows from trade and Africa was the continent with the largest embodied carbon outflows from trade. China was the country which had the largest embodied carbon outflows from trade, while the United States, France, Japan, and Germany were countries which had embodied carbon inflows from trade. OECD, EU, and NAFTA were the economic cooperation organizations with embodied carbon inflows from trade, while BRICS, SCO, RCEP, OPEC, and ASEAN were economic cooperation organizations with embodied carbon outflows from trade. Developed countries such as the United States, France, and the United Kingdom protected their environment by exporting high-value products and importing low-value and carbon-intensive products. Developing countries such as China and Russia earned foreign exchange by exporting carbon-intensive and commodity products at a huge environmental cost. In contrast, Germany, China, and Russia played different roles in the global industrial chain, while Germany exchanged more trade surpluses at lower environmental costs. Therefore, for different countries and regions, their own industries should be actively upgraded to adjust the import and export structure, the cooperation and coordination in all regions of the world should be strengthened, and the transfers of embodied carbon needs to be reduced to make the trade model sustainable.

The immunology and immunotherapy for COVID-19.

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and significantly impacts the world economy and daily life. Symptoms of COVID-19 range from asymptomatic to fever, dyspnoea, acute respiratory distress and multiple organ failure. Critical cases often occur in the elderly and patients with pre-existing conditions. By binding to the angiotensin-converting enzyme 2 receptor, SARS-CoV-2 can enter and replicate in the host cell, exerting a cytotoxic effect and causing local and systemic inflammation. Currently, there is no specific treatment for COVID-19, and immunotherapy has consistently attracted attention because of its essential role in boosting host immunity to the virus and reducing overwhelming inflammation. In this review, we summarise the immunopathogenic features of COVID-19 and highlight recent advances in immunotherapy to illuminate ideas for the development of new potential therapies.

Neural mechanisms underlying conflict monitoring over risky decision alternatives: evidence from ERP in a Go/Nogo task.

This study assessed conflict monitoring during presentation of risky decision alternatives, as indexed by the Nogo-N2, Nogo-P3, N2d and P3d event-related potentials (ERP). Decision-makers were tested on a Go/Nogo gambling task in which gain/loss outcomes as well as stimulus type (Go/Nogo) were equiprobable. Frontal-central Nogo-N2 and Nogo-P3 did not significantly differ across risky decision alternatives, whereas N2d and P3d amplitudes were more sensitive to the nature of risky decision alternatives. Frontal-central N2d was moderated by the magnitude of alternatives, with N2d amplitude greater for large than small alternatives, a result that suggests a greater degree of conflict monitoring for the former. Central P3d was associated with alternative valence, such that P3d amplitude was greater for loss than gain valences, again suggestive of more conflict monitoring for the former. The N2d and P3d potentials in risky decision alternatives are discussed in terms of the functional significance of the N2/P3 complex.

Response of ants to a deterrent factor(s) produced by the symbiotic bacteria of entomopathogenic nematodes.

The production of an ant-deterrent factor(s) (ADF) by Xenorhabdus nematophila and Photorhabdus luminescens, the symbiotic bacteria of the nematodes Steinernema carpocapsae and Heterorhabditis bacteriophora, respectively, was examined. In addition to an in vivo assay in which bacteria were tested for their ability to produce ADF within insect cadavers (M.E. Baur, H. K. Kaya, and D. R. Strong, Biol. Control 12:231-236, 1998), an in vitro microtiter dish assay was developed to monitor ADF activity produced by bacteria grown in cultures. Using these methods, we show that ADF activity is present in the supernatants of bacterial cultures, is filterable, heat stable, and acid sensitive, and passes through a 10-kDa-pore-size membrane. Thus, ADF appears to be comprised of a small, extracellular, and possibly nonproteinaceous compound(s). The amount of ADF repellency detected depends on the ant species being tested, the sucrose concentration (in vitro assays), and the strain, form, and age of the ADF-producing bacteria. These findings demonstrate that the symbiotic bacteria of some species of entomopathogenic nematodes produce a compound(s) that deters scavengers such as ants and thus could protect nematodes from being eaten during reproduction within insect cadavers.

Virulence and site of infection of the fungus, Hirsutella thompsonii, to the honey bee ectoparasitic mite, Varroa destructor.

The Varroa mite, Varroa destructor, is recognized as the most serious pest of both managed and feral Western honey bee (Apis mellifera) in the world. The mite has developed resistance to fluvalinate, an acaricide used to control it in beehives, and fluvalinate residues have been found in the beeswax, necessitating an urgent need to find alternative control measures to suppress this pest. Accordingly, we investigated the possibility of using the fungus, Hirsutella thompsonii, as a biocontrol agent of the Varroa mite. Among the 9 isolates of H. thompsonii obtained from the University of Florida and the USDA, only the 3 USDA isolates (ARSEF 257, 1947 and 3323) were infectious to the Varroa mite in laboratory tests. The mite became infected when it was allowed to walk on a sporulating H. thompsonii culture for 5 min. Scanning electron micrographs revealed that the membranous arolium of the mite leg sucker is the focus of infection where the fungal conidia adhered and germinated. The infected mites died from mycosis, with the lethal times to kill 50% (LT(50)s) dependent on the fungal isolates. Thus, the LT(50)s were 52.7, 77.2, and 96.7h for isolates 3323, 257, and 1947, respectively. Passage of H. thompsonii through Varroa mite three times significantly reduced the LT(50)s of isolates 257 and 1947 (P<0.05) but not the LT(50) of isolate 3323. The fungus did not infect the honey bee in larval, prepupal, pupal, and adult stages under our laboratory rearing conditions. Our encouraging results suggest that some isolates of H. thompsonii have the potential to be developed as a biocontrol agent for V. destructor. However, fungal infectivity against the mites under beehive conditions needs to be studied before any conclusion can be made.