RESUMO
Allosamidins come from the secondary metabolites of Streptomyces species, and they have the pseudotrisaccharide structures. Allosamidins are chitinase inhibitors that can be used to study the physiological effects of chitinases in a variety of organisms. They have the novel antiasthmatic activity and insecticidal/antifungal activities. Herein, the synthesis and activities of allosamidins were summarized and analyzed.
Assuntos
Acetilglucosamina/análogos & derivados , Antiasmáticos/farmacologia , Antifúngicos/farmacologia , Inseticidas/farmacologia , Trissacarídeos/farmacologia , Acetilglucosamina/química , Acetilglucosamina/isolamento & purificação , Acetilglucosamina/farmacologia , Animais , Antiasmáticos/química , Antiasmáticos/isolamento & purificação , Antifúngicos/química , Antifúngicos/isolamento & purificação , Asma/tratamento farmacológico , Fungos/efeitos dos fármacos , Humanos , Inseticidas/química , Inseticidas/isolamento & purificação , Conformação Molecular , Mariposas/efeitos dos fármacos , Streptomyces/química , Trissacarídeos/química , Trissacarídeos/isolamento & purificaçãoRESUMO
The pseudo-trisaccharide allosamidin 1 is a potent inhibitor of all family-18 chitinases, and it is confirmed to have insecticidal and antifungal activities. But the synthesis of allosamidins is very difficult, and it is a challengeable subject. Allosamidins were synthesized in solid-liquid phase, total solid-phase and total liquid-phase, respectively. Solid-liquid phase method realizes the partial solid-phase synthesis of allosamidins. Total solid-phase method greatly simplifies the purification process. Total liquid-phase method shortens the synthetic steps of allosamidins. The insecticidal and antifungal activities of allosamidins were also reported herein.