RESUMEN
Recognition of the presence, location, and properties of unusual accessory pathways for atrioventricular conduction is an exciting, frequently difficult, challenge for the clinical cardiac arrhythmologist. In this second part of our series of reviews relative to this topic, we discuss the steps required to achieve the correct diagnosis and appropriate management in patients with the so-called "Mahaim" variants of pre-excitation. We indicate that, nowadays, it is recognized that these abnormal rhythms are manifest because of the presence of atriofascicular pathways. These anatomical substrates, however, need to be distinguished from the other long and short accessory pathways which produce decremental atrioventricular conduction. The atriofascicular pathways, along with the long decrementally conducting pathways, have their atrial components located within the vestibule of the tricuspid valve. The short decremental pathways, in contrast, can originate in the vestibules of either the mitral or tricuspid valves. As a starting point, careful analysis of the 12-lead electrocardiogram, taken during both sinus rhythm and tachycardias, should precede any investigation in the catheterization room. When assessing the patient in the electrophysiological laboratory, the use of programmed electrical stimulation from different intracardiac locations, combined with entrainment technique and activation mapping, should permit the establishment of the properties of the accessory pathways, and localization of its proximal and distal ends. This should provide the answer to the question "is the pathway incorporated into the circuit underlying the clinical tachycardia". That information is essential for decision-making with regard to need, and localization of the proper site, for catheter ablation.
Asunto(s)
Fascículo Atrioventricular Accesorio/cirugía , Potenciales de Acción , Ablación por Catéter , Frecuencia Cardíaca , Preexcitación Tipo Mahaim/cirugía , Fascículo Atrioventricular Accesorio/fisiopatología , Ablación por Catéter/efectos adversos , Electrocardiografía , Técnicas Electrofisiológicas Cardíacas , Humanos , Preexcitación Tipo Mahaim/diagnóstico , Preexcitación Tipo Mahaim/fisiopatología , Valor Predictivo de las Pruebas , Resultado del TratamientoRESUMEN
BACKGROUND: The differential diagnosis of a supraventricular tachycardia (SVT) is accomplished using a number of pacing maneuvers. The incidence and mechanism of a single ventricular premature beat (VPB) on initiation and termination of tachycardia were evaluated during programmed electrical stimulation (PES) of the heart in patients with the two most common regular SVTs: atrioventricular re-entrant tachycardia (AVNRT) and orthodromic atrioventricular tachycardia (AVRT). METHODS: Three hundred and thirty-seven consecutive patients aged above 18 years with an inducible sustained AVNRT or AVRT were prospectively enrolled. Patients with more than one tachyarrhythmia mechanism were excluded. Two hundred and seventeen patients (64.4%) had typical slow/fast AVNRT and 120 (35.6%) had an orthodromic AVRT using a rapidly conducting accessory pathway for V-A conduction. In this cross-sectional study, we specifically report the analysis of tachycardia induction and termination by a single VPB. RESULTS: Tachycardia induction with a single VPB during sinus rhythm was seen in 7 of 120 AVRT and in only one of the 217 patients with AVNRT, (5.8% vs. 0.3%, p < 0.05). When a single VPB was delivered during basic ventricular pacing these values were 28% versus 4%, respectively, (p < 0.001). Termination of tachycardia by a single VPB was observed in nine (4.1%) patients with AVNRT and in 57 (47.5%) with AVRT (p < 0.001). CONCLUSION: Initiation of SVT by a single VPB during sinus rhythm was uncommon and favored AVRT. Termination of SVT by a single VPB was commonly seen in AVRT but rarely in AVNRT. These findings can be of help when interpreting a noninvasive arrhythmia event recording.
Asunto(s)
Electrocardiografía , Taquicardia Supraventricular/etiología , Taquicardia Supraventricular/fisiopatología , Complejos Prematuros Ventriculares/complicaciones , Complejos Prematuros Ventriculares/fisiopatología , Adulto , Estudios Transversales , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios ProspectivosRESUMEN
Short QT syndrome is a malignant cardiac disease characterized by the presence of ventricular tachyarrhythmias leading to syncope and sudden cardiac death. Currently, international guidelines establish diagnostic criteria when QTc is below 340 ms. This entity is one of the main diseases responsible for sudden cardiac death in the pediatric population. In recent years, clinical, genetic and molecular advances in pathophysiological mechanisms related to short QT syndrome have improved diagnosis, risk stratification, and preventive measures. Despite these advances, automatic implantable cardiac defibrillator remains the most effective measure. Currently, six genes have been associated with short QT syndrome, which account for nearly 60% of clinically diagnosed families. Here, we review the main clinical hallmarks of the disease, focusing on the pediatric population.
Asunto(s)
Arritmias Cardíacas/terapia , Muerte Súbita Cardíaca/etiología , Síncope/etiología , Arritmias Cardíacas/complicaciones , Arritmias Cardíacas/fisiopatología , Niño , Desfibriladores Implantables , Electrocardiografía , Humanos , Guías de Práctica Clínica como AsuntoRESUMEN
BACKGROUND: Mutations in the cardiac ryanodine receptor gene (RyR2) underlie catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited arrhythmogenic disease occurring in the structurally intact heart. The proportion of patients with CPVT carrying RyR2 mutations is unknown, and the clinical features of RyR2-CPVT as compared with nongenotyped CPVT are undefined. METHODS AND RESULTS: Patients with documented polymorphic ventricular arrhythmias occurring during physical or emotional stress with a normal heart entered the study. The clinical phenotype of the 30 probands and of 118 family members was evaluated, and mutation screening on the RyR2 gene was performed. Arrhythmias documented in probands were: 14 of 30 bidirectional ventricular tachycardia, 12 of 30 polymorphic ventricular tachycardia, and 4 of 30 catecholaminergic idiopathic ventricular fibrillation; RyR2 mutations were identified in 14 of 30 probands (36% bidirectional ventricular tachycardia, 58% polymorphic ventricular tachycardia, 50% catecholaminergic idiopathic ventricular fibrillation) and in 9 family members (4 silent gene carriers). Genotype-phenotype analysis showed that patients with RyR2 CPVT have events at a younger age than do patients with nongenotyped CPVT and that male sex is a risk factor for syncope in RyR2-CPVT (relative risk=4.2). CONCLUSIONS: CPVT is a clinically and genetically heterogeneous disease manifesting beyond pediatric age with a spectrum of polymorphic arrhythmias. beta-Blockers reduce arrhythmias, but in 30% of patients an implantable defibrillator may be required. Genetic analysis identifies two groups of patients: Patients with nongenotyped CPVT are predominantly women and become symptomatic later in life; patients with RyR2 CPVT become symptomatic earlier, and men are at higher risk of cardiac events. These data provide a rationale for prompt evaluation and treatment of young men with RyR2 mutations.
Asunto(s)
Mutación , Canal Liberador de Calcio Receptor de Rianodina/genética , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/genética , Adolescente , Adulto , Secuencia de Aminoácidos , Catecolaminas , Niño , Preescolar , Muerte Súbita Cardíaca/epidemiología , Salud de la Familia , Femenino , Variación Genética , Genotipo , Humanos , Masculino , Linaje , Alineación de Secuencia , Tasa de Supervivencia , Taquicardia Ventricular/mortalidad , Taquicardia Ventricular/terapiaRESUMEN
OBJECTIVE: To evaluate whether left ventricular end-systolic (ESD) diameters < or = 51mm in patients (pt) with severe chronic mitral regurgitation (MR) are predictors of a poor prognosis after mitral valve surgery (MVS). METHODS: Eleven pt (aged 36 +/- 13 years) were studied in the preoperative period (pre), median of 36 days; in the early postoperative period (post1), median of 9 days; and in the late postoperative period (post2), mean of 38.5 +/- 37.6 months. Clinical and echocardiographic data were gathered from each pt with MR and systolic diameter > or = 51 mm (mean = 57 +/- 4mm) to evaluate the result of MVS. Ten patients were in NYHA Class III/IV. RESULTS: All but 2 pt improved in functional class. Two pt died from heart failure and infectious endocarditis 14 and 11 months, respectively, after valve replacement. According to ejection fraction (EF) in post2, we identified 2 groups: group 1 (n=6), whose EF decreased in post1, but increased in post2 (p=0.01) and group 2 (n=5), whose EF decreased progressively from post1 to post2 (p=0.10). All pt with symptoms lasting < or = 48 months had improvement in EF in post2 (p=0.01). CONCLUSION: ESD > or = 51 mm are not always associated with a poor prognosis after MVS in patients with MR. Symptoms lasting up to 48 months are associated with improvement in left ventricular function.
Asunto(s)
Insuficiencia de la Válvula Mitral/cirugía , Disfunción Ventricular Izquierda/cirugía , Adolescente , Adulto , Análisis de Varianza , Enfermedad Crónica , Diástole , Femenino , Humanos , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Cuidados Preoperatorios , Sístole , Factores de Tiempo , Resultado del TratamientoRESUMEN
Abstract Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disease caused by mutations in genes encoding sarcomere proteins. It is the major cause of sudden cardiac death in young high-level athletes. Studies have demonstrated a poorer prognosis when associated with specific mutations. The association between HCM genotype and phenotype has been the subject of several studies since the discovery of the genetic nature of the disease. This study shows the effect of a MYBPC3 compound variant on the phenotypic HCM expression. A family in which a young man had a clinical diagnosis of HCM underwent clinical and genetic investigations. The coding regions of the MYH7, MYBPC3 and TNNT2 genes were sequenced and analyzed. The proband present a malignant manifestation of the disease, and is the only one to express HCM in his family. The genetic analysis through direct sequencing of the three main genes related to this disease identified a compound heterozygous variant (p.E542Q and p.D610H) in MYBPC3. A family analysis indicated that the p.E542Q and p.D610H alleles have paternal and maternal origin, respectively. No family member carrier of one of the variant alleles manifested clinical signs of HCM. We suggest that the MYBPC3-biallelic heterozygous expression of p.E542Q and p.D610H may cause the severe disease phenotype seen in the proband.
Resumo A cardiomiopatia hipertrófica (CMH) é uma doença autossômica dominante causada por mutações em genes que codificam as proteínas dos sarcômeros. É a principal causa de morte súbita cardíaca em atletas jovens de alto nível. Estudos têm demonstrado um pior prognóstico associado a mutações específicas. A associação entre genótipo e fenótipo em CMH tem sido objeto de diversos estudos desde a descoberta da origem genética dessa doença. Este trabalho apresenta o efeito de uma mutação composta em MYBPC3 na expressão fenotípica da CMH. Uma família na qual um jovem tem o diagnóstico clínico de CMH foi submetida à investigação clínica e genética. As regiões codificadoras dos genes MYH7, MYBPC3 e TNNT2 foram sequenciadas e analisadas. O probando apresenta uma manifestação maligna da doença e é o único em sua família a desenvolver CMH. A análise genética pelo sequenciamento direto dos três principais genes relacionados à essa doença identificou uma variante em heterozigose composta (p.E542Q e p.D610H) em MYBPC3. A análise da família mostrou que os alelos p.E542Q e p.D610H tem origem paterna e materna, respectivamente. Nenhum familiar portador de um dos alelos variantes manifestou sinais clínicos de CMH. Sugerimos que a expressão heterozigótica bialélica de p.E542Q e p.D610H pode ser responsável pelo fenótipo severo da doença encontrada no probando.
Asunto(s)
Humanos , Masculino , Adolescente , Cardiomiopatía Hipertrófica/genética , Proteínas Portadoras/genética , Linaje , Fenotipo , Cardiomiopatía Hipertrófica/diagnóstico por imagen , Cartilla de ADN , Heterocigoto , Mutación/genéticaRESUMEN
OBJECTIVE: To analyze the effectiveness of surgical treatment of atrial fibrillation (AF) using bipolar radiofrequency ablation during mitral valve procedures of rheumatic etiology in heart surgery. METHODS: We retrospectively reviewed medical registries of 53 patients submitted to atrial ablation with bipolar radiofrequency energy during mitral valve surgery. Thirty four (64%) patients were women and the age varied from 27 to 72 years old (average: 49.3 ± 10.7 years). Aortic and/or tricuspid procedures were also present in 36 (68%) patients. Average time of reported atrial fibrillation was 41 months (from 3 to 192 months). Type of AF was classified as: paroxysmal in 8 patients, persistent in 3, permanent in 42. Left atrium had an average size of 52.9 ± 8.5 mm. The surgeries in these series were: 47 mitral valve replacements and 6 mitral valve repairs. Electrocardiografic follow up was 83% complete in 14 months. Data from 24h Holter were explored. RESULTS: Seven (13%) perioperative deaths were observed and survival after 14 months was 87%. Observed heart rhythm after 1 year of surgery was sinus rhythm in 25 (66%) patients, AF in 7 (18%), flutter in 7 (13%), junctional in 1 (3%). CONCLUSION: Bipolar radiofrequency ablation in patients submitted to mitral valve surgery of rheumatic etiology is effective in converting to sinus rhythm in 68% of patients after 14 months.
Asunto(s)
Fibrilación Atrial/cirugía , Ablación por Catéter/métodos , Frecuencia Cardíaca/fisiología , Enfermedades de las Válvulas Cardíacas/cirugía , Válvula Mitral/cirugía , Cardiopatía Reumática/cirugía , Adulto , Anciano , Ablación por Catéter/efectos adversos , Ablación por Catéter/mortalidad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
BACKGROUND: Atrial fibrillation with tissue ablation device through bipolar radiofrequency in conjunction with cardiac surgery has proven to be an effective method to treat this arrhythmia. OBJECTIVE: Describe the initial experience of the Instituto Nacional de Cardiologia in the surgical treatment of atrial fibrillation using bipolar radiofrequency device in patients undergoing cardiac surgery, reporting the results of postoperative follow-up of one year. METHODS: Between January 2008 and March 2009, 47 consecutive patients (36 women), with mean age of 53.7 ± 10.6 years, with atrial fibrillation for a mean period of 34.6 months (3-192 months) underwent surgical ablation of this arrhythmia, through bipolar radiofrequency during the procedure which led to the indication of surgery. Eight of them showed intermittent atrial fibrillation and 39, continued. Eighty-one percent underwent valve surgery as the main procedure. This is a one-year postoperative retrospective, observational evaluation of clinical variables and 24-h Holter. RESULTS: Out of the 47 patients, 40 survived one year. Out of these, 33 underwent 24 h Holter, at an average interval of 401 days after the surgery. The following rhythm distribution was found: 24 (73.0%) sinus, five (15.0%) atrial fibrillation, three (9.0%) atrial Flutter and one (3.0%) junctional rhythm. Two cerebrovascular accidents were observed, one of which was associated with supraventricular arrhythmia. CONCLUSION: Surgical ablation of atrial fibrillation with bipolar radiofrequency device concomitant with cardiac surgery is an effective method for treating this arrhythmia.
Asunto(s)
Fibrilación Atrial/cirugía , Ablación por Catéter/instrumentación , Fibrilación Atrial/fisiopatología , Ablación por Catéter/efectos adversos , Ablación por Catéter/mortalidad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
Catecholaminergic polymorphic ventricular tachycardia occurs in healthy children and young adults causing syncope and sudden cardiac death. This is a familial disease, which affect de novo mutation in 50% of the cases. At least two causative genes have been described to be localized in the chromosome 1; mutation of the ryanodine receptor gene and calsequestrin gene. The classical clinical presentation is syncope triggered by exercise and emotion in children and adolescents with no structural heart disease. Polymorphic ventricular tachycardia during treadmill testing, or after isoproterenol infusion, is the most common feature. Therapeutic options include, beta-blockers, calcium-channel blockers and, an implantable cardioverter defibrillator is indicated in high-risk patients. Risk stratification of this disease is very challenging, since some risk factors proved to be useful in some series but not in others. However, family history of sudden cardiac death and symptoms initiated in very young children are important predictors.
Asunto(s)
Antagonistas Adrenérgicos beta/efectos adversos , Propranolol/efectos adversos , Taquicardia Ventricular/inducido químicamente , Antagonistas Adrenérgicos beta/administración & dosificación , Niño , Diagnóstico Diferencial , Relación Dosis-Respuesta a Droga , Electrocardiografía Ambulatoria , Resultado Fatal , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Propranolol/administración & dosificación , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/fisiopatologíaRESUMEN
BACKGROUND: The prevalence of atrial fibrillation, expenses with the healthcare system and the associated high morbidity and mortality have justified the search for new therapeutic approaches. OBJECTIVE: To evaluate the reproducibility of the surgical technique, its safety and the initial outcome of the video-assisted surgery for the isolated atrial fibrillation ablation with bipolar radiofrequency. METHODS: Ten patients (90% men) with symptomatic atrial fibrillation (50% paroxystic type) that was refractory to drug therapy, with no heart disease that required concomitant surgical treatment, were submitted to arrhythmia ablation guided by thoracoscopy from May 2007 to May 2008. Clinical, laboratory and image variables were prospectively collected before, during surgery and at the postoperative follow-up. RESULTS: The surgery was carried out as planned in all patients. There was no intra-thoracic structure iatrogenic lesion or deaths. At the mean 6-month follow-up, 80% of the patients were free of atrial fibrillation. There was a significant improvement in the symptoms of New York Heart Association Functional Class heart failure (2.4 + or - 0.5 to 1.6 + or - 0.7; p = 0.011). There was no evidence of pulmonary vein stenosis at the angiotomography in this series. CONCLUSION: The video-assisted surgery for the treatment of atrial fibrillation is reproducible and safe. There is a heart failure symptom evolution improvement after the surgery.
Asunto(s)
Fibrilación Atrial/cirugía , Ablación por Catéter/métodos , Cirugía Torácica Asistida por Video , Adulto , Anciano , Ablación por Catéter/efectos adversos , Métodos Epidemiológicos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
OBJECTIVES: To analyze retrograde conduction during junctional ectopic tachycardia (JET) episodes and investigate the existence of a relationship between the presence of a retrograde block and the risk of atrioventricular block (AVB) development during radiofrequency ablation procedures in patients with nodal atrioventricular tachycardia (NAVT). METHODS: 145 male and female patients aged 16-84 years, with NAVT who had undergone radiofrequency catheter ablation in the posteroseptal region of the right atrium were studied. Evaluation criteria were anatomical location and electrophysiological behavior of retrograde conduction during NAVT, in order to understand the nodal reentrant circuit (classifying the tachycardia as typical or atypical), and monitoring of retrograde conduction during JET episodes for risk-predicting AVB events. RESULTS: Of the 145 patients studied, 132 (91%) met electrophysiological and anatomical criteria of the typical form of NAVT, and 13 (9%) of atypical form. During the ablation, 5.3% with the typical form and 30.8% of the atypical form presented risk events for AVB. After the ablation, complications were a total AVB episode in one patient and a first-degree AVB episode in another in the typical group, and one first-degree AVB in the atypical group. All three episodes were preceded by risk events and resulted in permanent nodal injury. CONCLUSION: Patients with atypical NAVT presented higher percentages of risk events for atrioventricular block than did patients with the typical form (p=0.021).A careful observation of retrograde conduction during JET episodes is vital in order to avoid permanent damage in AV nodal conduction, such as TAVB, after the ablation procedure.
Asunto(s)
Ablación por Catéter/efectos adversos , Bloqueo Cardíaco/fisiopatología , Taquicardia por Reentrada en el Nodo Atrioventricular/fisiopatología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Electrocardiografía , Técnicas Electrofisiológicas Cardíacas , Femenino , Bloqueo Cardíaco/patología , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Taquicardia por Reentrada en el Nodo Atrioventricular/etiología , Taquicardia por Reentrada en el Nodo Atrioventricular/patología , Taquicardia por Reentrada en el Nodo Atrioventricular/cirugíaRESUMEN
OBJETIVO: Avaliar a eficácia do tratamento cirúrgico da fibrilação atrial (FA) utilizando ablação com radiofrequência bipolar durante cirurgia cardíaca de procedimentos mitrais de etiologia reumática. MÉTODOS: Foram avaliados, retrospectivamente, os prontuários e exames de 53 pacientes submetidos à cirurgia valvar mitral, com ou sem cirurgia tricúspide ou aórtica associada, em que foi realizada ablação de FA utilizando radiofrequência bipolar. Trinta e quatro (64 por cento) pacientes eram mulheres e a idade variou de 27 a 72 anos (média: 49,3 anos ± 10,7 anos). O tempo médio de FA relatado foi de 41 meses (variou de 3 a 192 meses). O tipo de FA apresentado foi: paroxística em oito pacientes, persistente em três, permanente em 42. O átrio esquerdo apresentava tamanho médio de 52,9 ± 8,5 mm. As cirurgias realizadas foram: 47 trocas de valva mitral e seis plastias mitrais. O seguimento eletrocardiográfico foi completo em 83 por cento dos pacientes, ao final de 14 meses. Informações adicionais oriundas de Holter 24h foram exploradas. RESULTADOS: Ocorreram sete (13 por cento) óbitos per-operatórios e a sobrevida após 14 meses foi de 87 por cento. Os ritmos cardíacos encontrados após um ano de cirurgia foram: sinusal em 25 (66 por cento) pacientes, FA em sete (18 por cento), Flutter em cinco (13 por cento), Juncional em um (3 por cento). CONCLUSÃO: O uso de radiofrequência bipolar para tratamento de FA em pacientes submetidos à cirurgia valvar mitral de origem reumática é efetivo no controle da arritmia em 68 por cento dos pacientes, após 14 meses.
OBJECTIVE: To analyze the effectiveness of surgical treatment of atrial fibrillation (AF) using bipolar radiofrequency ablation during mitral valve procedures of rheumatic etiology in heart surgery. METHODS: We retrospectively reviewed medical registries of 53 patients submitted to atrial ablation with bipolar radiofrequency energy during mitral valve surgery. Thirty four (64 percent) patients were women and the age varied from 27 to 72 years old (average: 49.3 ± 10.7 years). Aortic and/or tricuspid procedures were also present in 36 (68 percent) patients. Average time of reported atrial fibrillation was 41 months (from 3 to 192 months). Type of AF was classified as: paroxysmal in 8 patients, persistent in 3, permanent in 42. Left atrium had an average size of 52.9 ± 8.5 mm. The surgeries in these series were: 47 mitral valve replacements and 6 mitral valve repairs. Eletrocardiografic follow up was 83 percent complete in 14 months. Data from 24h Holter were explored. RESULTS: Seven (13 percent) perioperative deaths were observed and survival after 14 months was 87 percent. Observed heart rhythm after 1 year of surgery was sinus rhythm in 25 (66 percent) patients, AF in 7 (18 percent), flutter in 7 (13 percent), junctional in 1 (3 percent). CONCLUSION: Bipolar radiofrequency ablation in patients submitted to mitral valve surgery of rheumatic etiology is effective in converting to sinus rhythm in 68 percent of patients after 14 months.
Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fibrilación Atrial/cirugía , Ablación por Catéter/métodos , Frecuencia Cardíaca/fisiología , Enfermedades de las Válvulas Cardíacas/cirugía , Válvula Mitral/cirugía , Cardiopatía Reumática/cirugía , Ablación por Catéter/efectos adversos , Ablación por Catéter/mortalidad , Estudios de Seguimiento , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
FUNDAMENTO: O tratamento da fibrilação atrial com dispositivo de ablação de tecidos por radiofrequência bipolar em concomitância à cirurgia cardíaca tem se mostrado método eficaz no tratamento desta arritmia. OBJETIVO: Descrever a experiência inicial do Instituto Nacional de Cardiologia no tratamento cirúrgico da fibrilação atrial com uso de dispositivo de radiofrequência bipolar em pacientes submetidos à cirurgia cardíaca, relatando o resultado de acompanhamento pós-operatório de um ano. MÉTODOS: Entre janeiro de 2008 e março de 2009, 47 pacientes (36 mulheres) consecutivos, com idade média de 53,7 ± 10,6 anos, apresentando fibrilação atrial por um período médio de 34,6 meses (3 a 192 meses) foram submetidos à ablação cirúrgica desta arritmia, por radiofrequência bipolar, durante o procedimento que motivou a indicação da cirurgia. Oito apresentavam fibrilação atrial intermitente e 39, contínua. Oitenta e um por cento foram submetidos à cirurgia valvar como procedimento principal. Esta é uma análise retrospectiva, observacional, com avaliação de um ano de pós-operatório das variáveis clínicas e de Holter 24 h. RESULTADOS: Dos 47 pacientes, 40 sobreviveram um ano. Desses, 33 foram submetidos a Holter 24 h, em um intervalo médio de 401 dias após a cirurgia. Encontrou-se a seguinte distribuição de ritmos: 24 (73 por cento) sinusal, 5 (15 por cento) fibrilação atrial, três (9 por cento) Flutter atrial e um (3 por cento) ritmo juncional. Foram observados dois acidentes vasculares encefálicos, sendo um associado à arritmia supraventricular. CONCLUSÃO: A ablação cirúrgica de fibrilação atrial com dispositivo de radiofrequência bipolar concomitante à cirurgia cardíaca é método eficaz para o tratamento desta arritmia.
BACKGROUND: Atrial fibrillation with tissue ablation device through bipolar radiofrequency in conjunction with cardiac surgery has proven to be an effective method to treat this arrhythmia. OBJECTIVE: Describe the initial experience of the Instituto Nacional de Cardiologia in the surgical treatment of atrial fibrillation using bipolar radiofrequency device in patients undergoing cardiac surgery, reporting the results of postoperative follow-up of one year. METHODS: Between January 2008 and March 2009, 47 consecutive patients (36 women), with mean age of 53.7 ± 10.6 years, with atrial fibrillation for a mean period of 34.6 months (3-192 months) underwent surgical ablation of this arrhythmia, through bipolar radiofrequency during the procedure which led to the indication of surgery. Eight of them showed intermittent atrial fibrillation and 39, continued. Eighty-one percent underwent valve surgery as the main procedure. This is a one-year postoperative retrospective, observational evaluation of clinical variables and 24-h Holter. RESULTS: Out of the 47 patients, 40 survived one year. Out of these, 33 underwent 24 h Holter, at an average interval of 401 days after the surgery. The following rhythm distribution was found: 24 (73.0 percent) sinus, five (15.0 percent) atrial fibrillation, three (9.0 percent) atrial Flutter and one (3.0 percent) junctional rhythm. Two cerebrovascular accidents were observed, one of which was associated with supraventricular arrhythmia. CONCLUSION: Surgical ablation of atrial fibrillation with bipolar radiofrequency device concomitant with cardiac surgery is an effective method for treating this arrhythmia.
FUNDAMENTO: El tratamiento de la fibrilación atrial con dispositivo de ablación de tejidos por radiofrecuencia bipolar en concomitancia con la cirugía cardíaca se muestra un método eficaz en el tratamiento de esta arritmia. OBJETIVO: Describir la experiencia inicial del Instituto Nacional de Cardiología en el tratamiento quirúrgico de la fibrilación atrial con uso de dispositivo de radiofrecuencia bipolar en pacientes sometidos a cirugía cardíaca, relatando el resultado de seguimiento postoperatorio de un año. MÉTODOS: Entre enero de 2008 y marzo de 2009, 47 pacientes (36 mujeres) consecutivos, con edad promedio de 53,7 ± 10,6 años, presentando fibrilación atrial por un período promedio de 34,6 meses (3 a 192 meses) fueron sometidos a ablación quirúrgica de esta arritmia, por radiofrecuencia bipolar, durante el procedimiento que motivó la indicación de la cirugía. Ocho presentaban fibrilación atrial intermitente y 39, continua. El 81 por ciento fue sometido a cirugía valvular como procedimiento principal. Éste es un análisis retrospectivo, observacional, con evaluación de un año de postoperatorio de las variables clínicas y de Holter 24 h. RESULTADOS: De los 47 pacientes, 40 sobrevivieron un año. De ellos, 33 fueron sometidos a Holter 24 h, en un intervalo promedio de 401 días después de la cirugía. Se encontró la siguiente distribución de ritmos: 24 (73 por ciento) sinusal, 5 (15 por ciento) fibrilación atrial, tres (9 por ciento) flutter atrial y un (3 por ciento) ritmo de la unión. Se observaron dos accidentes vasculares encefálicos, siendo uno asociado a la arritmia supraventricular. CONCLUSIÓN: La ablación quirúrgica de fibrilación atrial con dispositivo de radiofrecuencia bipolar concomitante a la cirugía cardíaca es método eficaz para el tratamiento de esta arritmia.
Asunto(s)
Femenino , Humanos , Masculino , Persona de Mediana Edad , Fibrilación Atrial/cirugía , Ablación por Catéter/instrumentación , Fibrilación Atrial/fisiopatología , Ablación por Catéter/efectos adversos , Ablación por Catéter/mortalidad , Estudios de Seguimiento , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
INTRODUCTION: Automatic rhythms associated with Mahaim fibers usually occur during radiofrequency catheter ablation. The incidence and significance of spontaneous automaticity in Mahaim fibers are unknown. METHODS AND RESULTS: Spontaneous automatic rhythms were observed in 5 (12.5%) of 40 patients with Mahaim fibers referred for nonpharmacologic therapy because of recurrent episodes of symptomatic tachyarrhythmias, usually antidromic circus movement tachycardia (33/40 patients). Three were female and two were male. Their mean age was 15 +/- 7 years compared to 26 +/- 13 years of the patients without automaticity (P = 0.09). Three patients had both antidromic tachycardia and asymptomatic spontaneous automatic rhythms recorded during ambulatory ECG (1 patient) or electrophysiologic study (2 patients). In 2 patients, the automatic rhythm triggered antidromic tachycardia. Two other patients had nonsustained repetitive episodes of wide QRS tachycardia due to automaticity arising in the Mahaim fiber, without antidromic tachycardia. All automatic rhythms were abolished by successful catheter ablation of the Mahaim fibers. CONCLUSION: Spontaneous automaticity occurred in 12.5% of our Mahaim patients and may trigger antidromic tachycardia. Spontaneous automaticity, which is not seen in rapidly conducting accessory pathways, is another argument for the presence of an AV nodal-like structure in Mahaim fibers.
Asunto(s)
Preexcitación Tipo Mahaim/fisiopatología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Nodo Atrioventricular/fisiopatología , Ablación por Catéter , Electrocardiografía , Electrofisiología , Femenino , Sistema de Conducción Cardíaco/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Preexcitación Tipo Mahaim/cirugíaRESUMEN
FUNDAMENTO: A prevalência da fibrilação atrial, os gastos com o sistema de saúde e a elevada morbidade e mortalidade associadas a ela, têm justificado a procura por novas abordagens terapêuticas. OBJETIVO: Avaliar a reprodutibilidade da técnica cirúrgica, a segurança e os resultados inicias da cirurgia vídeo-assistida para a ablação da fibrilação atrial isolada com radiofrequência bipolar. MÉTODOS: Dez pacientes (90 por cento homens) com fibrilação atrial (50 por cento paroxística) sintomática e refratária à terapia medicamentosa, sem doença cardíaca que requeresse cirurgia concomitante, foram submetidos à ablação da arritmia guiada por toracoscopia, no período de maio de 2007 a maio de 2008. Variáveis clínicas, laboratoriais e de imagem foram prospectivamente coletadas antes, durante e no seguimento pós-operatório. RESULTADOS: A cirurgia foi realizada conforme o planejado em todos os pacientes. Não houve lesão iatrogênica de estruturas intratorácicas ou óbitos. No seguimento médio de seis meses, 80 por cento dos pacientes estão livres de fibrilação atrial. Houve melhora significativa dos sintomas de insuficiência cardíaca classe funcional New York Heart Association (2,4 ± 0,5 para 1,6 ± 0,7; p = 0,011). Não houve evidência de estenose de veias pulmonares à angiotomografia, nesta série. CONCLUSÃO: A cirurgia vídeo-assistida para o tratamento da fibrilação atrial é reprodutível e segura. Há melhora evolutiva dos sintomas de insuficiência cardíaca após a cirurgia.
BACKGROUND: The prevalence of atrial fibrillation, expenses with the healthcare system and the associated high morbidity and mortality have justified the search for new therapeutic approaches. OBJECTIVE: To evaluate the reproducibility of the surgical technique, its safety and the initial outcome of the video-assisted surgery for the isolated atrial fibrillation ablation with bipolar radiofrequency. METHODS: Ten patients (90 percent men) with symptomatic atrial fibrillation (50 percent paroxystic type) that was refractory to drug therapy, with no heart disease that required concomitant surgical treatment, were submitted to arrhythmia ablation guided by thoracoscopy from May 2007 to May 2008. Clinical, laboratory and image variables were prospectively collected before, during surgery and at the postoperative follow-up. RESULTS: The surgery was carried out as planned in all patients. There was no intra-thoracic structure iatrogenic lesion or deaths. At the mean 6-month follow-up, 80 percent of the patients were free of atrial fibrillation. There was a significant improvement in the symptoms of New York Heart Association Functional Class heart failure (2.4 ± 0.5 to 1.6 ± 0.7; p=0.011). There was no evidence of pulmonary vein stenosis at the angiotomography in this series. CONCLUSION: The video-assisted surgery for the treatment of atrial fibrillation is reproducible and safe. There is a heart failure symptom evolution improvement after the surgery.
Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fibrilación Atrial/cirugía , Ablación por Catéter/métodos , Cirugía Torácica Asistida por Video , Ablación por Catéter/efectos adversos , Métodos Epidemiológicos , Resultado del TratamientoRESUMEN
O objetivo do trabalho foi realizar uma revisão de literatura sobre a desfibrilação precoce intra e extra hospitalar, utilizando um conceito fase dependente (elétrica, circulatória e metabólica). Ele acentua a importância do uso do desfibrilador externo automático (DEA) e sua aplicação precocemente na parada cardíaca. O tempo do colapso até a desfibrilação é um determinante importante de sobrevivência principalemnte com função cerebral preservada. Também é ressaltada a importância das compressões torácicas na tentativa de ressuscitação, especialmente se o tempo de parada exceder de 4 a 5 minutos.
Asunto(s)
Humanos , Masculino , Femenino , Niño , Adulto , Desfibriladores/normas , Desfibriladores , Paro Cardíaco/complicaciones , Paro Cardíaco/mortalidad , Reanimación Cardiopulmonar/métodos , Reanimación Cardiopulmonar/normasRESUMEN
Objetivo: Determinar a qualidade de vida em 25 pacientes portadores de fibrilação atrial, antes e após aablação por cateter. Métodos: Aplicação de dois questionários, sendo um genérico (SF-36) para avaliar a qualidade de vida relacionada à saúde, compreendendo oito domínios. Ooutro questionário aplicado foi específico: Qualidade de Vida em Fibrilação Atrial (QVFA), compreendendo sete componentes. Os questionários foram aplicados em 25pacientes (20 do sexo masculino) portadores de fibrilação atrial paroxística, indicados para se submeterem à ablação por cateter, no período de julho de 2004 a novembro de2005, e três meses após o procedimento. As variáveis foram comparadas, utilizando-se o teste de Willcoxon. Resultados: Os resultados mostraram uma melhora significativa em cinco domínios do questionário QVFA,com os seguintes escores: palpitação (11,43 e pós 7,18), dispnéia (6,68 e pós 3,08), tontura (5,08 e pós 2,64),medicação (3,88 e pós 2,52) e total do escore (33,02 e pós 19,80). Nos resultados do questionário SF-36, observouse uma melhora significativa no domínio de capacidade funcional (64,06 e pós 77,29). Conclusões: Pacientes com fibrilação atrial obtiveramuma melhora na qualidade de vida relacionada à saúde após ablação por cateter.
Objective: To assess the quality of life in 25 patients with atrial fibrillation after catheter ablation. Methods: Two questionnaires were completed. Onewas the more general Short Form SF-36 Health Survey Questionnaire that assesses the quality of life througheight aspects, scored from 0 to 100, with higher scores reflecting a better quality of life. The other was the morespecific Quality of Life with Atrial Fibrillation (QVFA) questionnaire, with seven subscales. These questionnaireswere competed by 25 patients (twenty of them male) with paroxysmal atrial fibrillation recommended for catheterablation, and then repeated three months after the procedure, between July 2004 and November 2005. Thevariables were compared through the Willcoxon Test. Results: The findings showed significant improvementsfor five aspects covered by the QVFA questionnaire, with the following scores: palpitations (before: 11.43 / after: 7.18); dyspnea (before: 6.68 / after: 3.08); dizziness (before: 5.08 / after: 2.64); medication (before: 3.88 / after:2.52); and the total scores (before: 33.02 / after: 19.80). The findings of the SF-36 questionnaire showed asignificant improvement in their functional capacity (before: 64.06 / after: 77.29). Conclusions: Patients with atrial fibrillation presented abetter quality of life in terms of their health after catheter ablation. The QFVA questionnaire is more sensitive than the more general SF-36 questionnaire, in terms of reflecting differences in the quality of life of patients with atrial fibrillation.