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1.
Australas J Dermatol ; 62(2): 213-216, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33421095

RESUMEN

Syringotropic mycosis fungoides is a very rare variant of cutaneous T-cell lymphomas characterised by prominent involvement of the eccrine glands. Hypereosinophilic syndrome refers to a rare group of conditions that are associated with persistent eosinophilia with organ involvement. It is classified into idiopathic, primary and secondary (reactive). We report herein an unusual case of hypereosinophilic syndrome with great impact on morbidity, which developed in a patient with human immunodeficiency virus infection and long-time misdiagnosed syringotropic mycosis fungoides.


Asunto(s)
Infecciones por VIH/complicaciones , Síndrome Hipereosinofílico/patología , Micosis Fungoide/patología , Neoplasias Cutáneas/patología , Humanos , Masculino , Persona de Mediana Edad
2.
Am J Dermatopathol ; 39(2): 150-152, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28134733

RESUMEN

Papillary dermal elastosis is a rare clinicopathological entity with only 1 case reported. The authors herein report a new case. A 38-year-old woman presented with a 10-month history of slowly progressive appearance of multiple, 1-2 mm, pruritic nonfollicular papules, located on the back. The study of the biopsy with the ordinary staining revealed numerous dermal papillae showing increased elastosis. The Verhoeff elastic stain demonstrated numerous foci of clumped and curled elastic fibers in the papillary dermis. The elastic component of the reticular dermis was normal. This case report confirms this entity and can contribute to a better understanding of the spectrum of the fibroelastolytic entities.


Asunto(s)
Tejido Elástico/patología , Enfermedades de la Piel/patología , Adulto , Dorso/patología , Femenino , Humanos
5.
J Cutan Pathol ; 39(8): 798-802, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22804110

RESUMEN

Accessory breast tissue is a subcutaneous remnant persisting after normal embryological development of the breast. It occurs most frequently in the axilla. Fibroadenomas in axillary breast tissue are rare. We report the case of a 29-year-old female patient who presented a fibroadenoma arising in the accessory breast tissue of the right axillary fossa. The neoplasm showed foci of sclerotic fibroma-like stroma. The patient had no signs of Cowden's syndrome. To the best of our knowledge, a lesion of this kind has not been previously reported. This stromal change suggests an uncommon involutional phase of the fibroadenoma with production of sclerotic and hypocellular collagen. The lesion should be differentiated from extraneural perineuroma, from the changes in fibroadenomas in Cowden's syndrome, from sclerosing lobular hyperplasia (fibroadenomatoid mastopathy) and from pseudoangiomatous stromal hyperplasia.


Asunto(s)
Neoplasias de la Mama/patología , Mama , Coristoma/patología , Fibroadenoma/patología , Fibroma/patología , Adulto , Angiomatosis/diagnóstico , Axila/patología , Enfermedades de la Mama/diagnóstico , Neoplasias de la Mama/metabolismo , Neoplasias de la Mama/cirugía , Coristoma/metabolismo , Coristoma/cirugía , Colágeno/metabolismo , Diagnóstico Diferencial , Femenino , Fibroadenoma/metabolismo , Fibroadenoma/cirugía , Enfermedad Fibroquística de la Mama/diagnóstico , Fibroma/metabolismo , Fibroma/cirugía , Síndrome de Hamartoma Múltiple/diagnóstico , Humanos , Hiperplasia/diagnóstico , Neoplasias de la Vaina del Nervio/diagnóstico , Esclerosis , Células del Estroma/metabolismo , Células del Estroma/patología
7.
J Invest Dermatol ; 142(5): 1391-1400.e15, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-34687742

RESUMEN

Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced by deregulated TCR/PLCγ1 activity, controlling the biology of these lesions. In addition, activated signal transducer and activator of transcription 3 is associated with clinical progression, although the alterations responsible for this have not been fully elucidated. Here, we studied PLCγ1-dependent mechanisms that can mediate STAT3 activation and control tumor growth and progression. Downstream of PLCγ1, the pharmacological inhibition and genetic knockdown of protein kinase C theta (PKCθ) inhibited signal transducer and activator of transcription 3 activation, impaired proliferation, and promoted apoptosis in cutaneous T-cell lymphoma cells. A PKCθ-dependent transcriptome in mycosis fungoides/Sézary syndrome cells revealed potential effector genes controlling cytokine signaling, TP53, and actin cytoskeleton dynamics. Consistently, an in vivo chicken embryo model xenografted with mycosis fungoides cells showed that PKCθ blockage abrogates tumor growth and spread to distant organs. Finally, the expression of a number of PKCθ target genes found in mycosis fungoides cells significantly correlated with that of PRKCQ (PKCθ) in 81 human mycosis fungoides samples. In summary, PKCθ can play a central role in the activation of malignant cutaneous T-cell lymphoma mechanisms via multiple routes, including, but not restricted to, STAT3. These mechanisms may, in turn, serve as targets for specific therapies.


Asunto(s)
Linfoma Cutáneo de Células T , Micosis Fungoide , Neoplasias Cutáneas , Animales , Embrión de Pollo , Linfoma Cutáneo de Células T/genética , Micosis Fungoide/genética , Proteína Quinasa C-theta/genética , Proteína Quinasa C-theta/metabolismo , Factor de Transcripción STAT3/metabolismo , Neoplasias Cutáneas/genética
8.
J Cutan Pathol ; 36(10): 1109-13, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19187105

RESUMEN

Eosinophilic (Langerhans' cell) granuloma is most common in children and is unusual in the elderly. A cutaneous lesion as the sole manifestation of adult Langerhans' cell histiocytosis is rare. We report an 81-year-old man who presented with a noduloulcerative lesion on the lower lip. A punch biopsy suggested a lymphoepithelioma-like carcinoma. In the absence of immunohistochemistry, the large pale cells with atypical lobular nuclei and patent nucleoli, with an overlying ulceration, were interpreted as carcinoma cells. Definitive diagnosis was established after complete resection of the lesion aided with the use of immunohistochemistry. The proliferating cells were S100, CD1a and CD207 (langerin) positive and cytokeratin, epithelial membrane antigen, CD15, CD30, melan A and carcinoembryonic antigen negative. To our knowledge, eosinophilic (Langerhans' cell) granuloma of the lip has not been described. The case constituted a diagnostic challenge because of its unusual clinical presentation and its histopathological similarity to certain other benign and malignant entities. Because there was no other organ involved, the patient was treated with complete surgical excision without recurrence or other organ involvement in the 4-month follow-up period. Labial eosinophilic (Langerhans' cell) granuloma should be considered in the histological differential diagnosis in cases with atypical polymorphous infiltrates including large pale cells.


Asunto(s)
Carcinoma/patología , Errores Diagnósticos , Granuloma Eosinófilo/patología , Labio/patología , Adenocarcinoma/complicaciones , Anciano de 80 o más Años , Fibrilación Atrial/complicaciones , Biomarcadores de Tumor/análisis , Biopsia , Granuloma Eosinófilo/complicaciones , Humanos , Inmunohistoquímica , Masculino , Neoplasias del Colon Sigmoide/complicaciones , Accidente Cerebrovascular/complicaciones
9.
Pathol Int ; 58(7): 442-4, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18577114

RESUMEN

Lymphangioma is a rare benign lesion of the gastrointestinal tract, in which the large intestine is the least commonly involved site. To the authors' knowledge a lymphangioma of the anal canal has not been reported. Described herein is a case of pedunculated polypoid lymphangioma of the right lateral wall on the transitional zone of the anal canal measuring 1.7 x 1.3 x 1 cm in a 40-year-old woman. A pedicle does not exclude the endoscopic diagnosis of lymphangioma. Lymphangioma must be included in the differential diagnosis of polypoid lesions of the anal canal.


Asunto(s)
Neoplasias del Ano/patología , Linfangioma/patología , Adenocarcinoma/patología , Adulto , Carcinoma de Células Escamosas/patología , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Fístula Rectal/patología
12.
J Cutan Pathol ; 34(12): 942-5, 2007 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-18001419

RESUMEN

A neoplasm associated with a pilonidal sinus (PS) is a rare occurrence in the course of a common disease. Early detection is imperative. To our knowledge, pilonidal disease associated with a cellular blue nevus (CBN) has not been reported. There is a 10% diagnostic error rate with this last lesion. Here we report the case of a 19-year-old man with recurrent sacrococcygeal PS infection associated with an indurated dome-shaped blue-black nodule 1.7 cm in diameter. Clinical diagnosis of the nodule was uncertain suggesting a pigmentary or a vascular tumor. A complete resection of the two lesions was achieved. Pathological study showed a CBN showing a predominantly alveolar pattern associated with a chronic pilonidal disease. The tumor cells showed diffuse strong reactivity for melan-A and HMB-45, and focal reactivity for S-100 protein. Staining for Ki-67 (MIB1) was virtually negative. Differential diagnoses included atypical CBN, borderline melanocytic tumor and malignant melanoma. Radical excision provides a good prognosis for the rare association consisting of a common disease such as PS with the uncommon CBN.


Asunto(s)
Nevo Azul/complicaciones , Seno Pilonidal/complicaciones , Neoplasias Cutáneas/complicaciones , Adulto , Diagnóstico Diferencial , Humanos , Inmunohistoquímica , Masculino , Melanoma/patología , Nevo Azul/metabolismo , Nevo Azul/patología , Seno Pilonidal/metabolismo , Seno Pilonidal/patología , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patología
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