Suction effects of craters under water.

Octopus-inspired cratered surfaces have recently emerged as a new class of reusable physical adhesives. Preload-dependent adhesion and enhanced adhesion under water distinguish them from the well-studied gecko-inspired pillared surfaces. Despite growing experimental evidence, modeling frameworks and mechanistic understanding of cratered surfaces are still very limited. We recently developed a framework to evaluate suction forces produced by isolated craters in air. In this paper, we focus on underwater craters. The suction force-preload relation predicted by this framework has been validated by experiments carried out with an incompressible fluid under small and moderate preloads. Our model breaks down under a large preload due to multiple possible reasons including liquid vaporization. A direct comparison between liquid and air-filled craters has been carried out and the dependence on the depth of water has been revealed. We find that the suction forces generated by underwater craters scale with the specimen modulus but exhibit non-monotonic dependence on the aspect ratio of the craters.

Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors.

Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.

Stretchable Tattoo-Like Heater with On-Site Temperature Feedback Control.

Wearable tissue heaters can play many important roles in the medical field. They may be used for heat therapy, perioperative warming and controlled transdermal drug delivery, among other applications. State-of-the-art heaters are too bulky, rigid, or difficult to control to be able to maintain long-term wearability and safety. Recently, there has been progress in the development of stretchable heaters that may be attached directly to the skin surface, but they often use expensive materials or processes and take significant time to fabricate. Moreover, they lack continuously active, on-site, unobstructive temperature feedback control, which is critical for accommodating the dynamic temperatures required for most medical applications. We have developed, fabricated and tested a cost-effective, large area, ultra-thin and ultra-soft tattoo-like heater that has autonomous proportional-integral-derivative (PID) temperature control. The device comprises a stretchable aluminum heater and a stretchable gold resistance temperature detector (RTD) on a soft medical tape as fabricated using the cost and time effective "cut-and-paste" method. It can be noninvasively laminated onto human skin and can follow skin deformation during flexure without imposing any constraint. We demonstrate the device's ability to maintain a target temperature typical of medical uses over extended durations of time and to accurately adjust to a new set point in process. The cost of the device is low enough to justify disposable use.

Monolithically integrated stretchable photonics.

Mechanically stretchable photonics provides a new geometric degree of freedom for photonic system design and foresees applications ranging from artificial skins to soft wearable electronics. Here we describe the design and experimental realization of the first single-mode stretchable photonic devices. These devices, made of chalcogenide glass and epoxy polymer materials, are monolithically integrated on elastomer substrates. To impart mechanical stretching capability to devices built using these intrinsically brittle materials, our design strategy involves local substrate stiffening to minimize shape deformation of critical photonic components, and interconnecting optical waveguides assuming a meandering Euler spiral geometry to mitigate radiative optical loss. Devices fabricated following such design can sustain 41% nominal tensile strain and 3000 stretching cycles without measurable degradation in optical performance. In addition, we present a rigorous analytical model to quantitatively predict stress-optical coupling behavior in waveguide devices of arbitrary geometry without using a single fitting parameter.

Suction effects in cratered surfaces.

It has been shown experimentally that cratered surfaces may have better adhesion properties than flat ones. However, the suction effect produced by the craters, which may be chiefly responsible for the improved adhesion, has not been properly modelled. This paper combines experimental, numerical simulation and analytical approaches towards developing a framework for quantifying the suction effect produced by isolated craters and cratered surfaces. The modelling approach emphasizes the essential role of large elastic deformation, while the airflow dynamics, microscopic mechanisms, like surface tension and air permeation, and rate-dependence are neglected. This approach is validated using experimental data for isolated hemi-spherical craters. The modelling approach is further applied to spherical cap (not necessarily hemi-spherical) craters with the objective of identifying optimal geometric and material properties, as well as the minimum preload necessary for attaining the maximum suction force. It is determined that stiff polymers with deep craters are capable of producing large suction forces. For soft materials, central to biomedical applications, large suction forces can be attained by reinforcing deep craters with thin stiff layers. Parametric optimization studies of reinforced craters reveal that some of them perform beyond common expectations. However, those high-performance reinforced craters are prone to surface instabilities, and therefore the practical use of such craters may be problematic.

Multifunctional cell-culture platform for aligned cell sheet monitoring, transfer printing, and therapy.

While several functional platforms for cell culturing have been proposed for cell sheet engineering, a soft integrated system enabling in vitro physiological monitoring of aligned cells prior to their in vivo applications in tissue regeneration has not been reported. Here, we present a multifunctional, soft cell-culture platform equipped with ultrathin stretchable nanomembrane sensors and graphene-nanoribbon cell aligners, whose system modulus is matched with target tissues. This multifunctional platform is capable of aligning plated cells and in situ monitoring of cellular physiological characteristics during proliferation and differentiation. In addition, it is successfully applied as an in vitro muscle-on-a-chip testing platform. Finally, a simple but high-yield transfer printing mechanism is proposed to deliver cell sheets for scaffold-free, localized cell therapy in vivo. The muscle-mimicking stiffness of the platform allows the high-yield transfer printing of multiple cell sheets and results in successful therapies in diseased animal models. Expansion of current results to stem cells will provide unique opportunities for emerging classes of tissue engineering and cell therapy technologies.

Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases.

Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.

Multifunctional wearable devices for diagnosis and therapy of movement disorders.

Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.