Pesquisa | BVS Violência e Saúde

1.

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.

Hruska-Plochan, Marian; Wiersma, Vera I; Betz, Katharina M; Mallona, Izaskun; Ronchi, Silvia; Maniecka, Zuzanna; Hock, Eva-Maria; Tantardini, Elena; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Pérez-Berlanga, Manuela; Gatta, Beatrice; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Sharma, Puneet; De Vos, Laura; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini.

Nature ; 626(8001): 1073-1083, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38355792

2.

A template for new drugs against Alzheimer's disease.

Aguzzi, Adriano; Gitler, Aaron D.

Cell ; 154(6): 1182-4, 2013 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-24034239

3.

Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Krautler, Nike Julia; Kana, Veronika; Kranich, Jan; Tian, Yinghua; Perera, Dushan; Lemm, Doreen; Schwarz, Petra; Armulik, Annika; Browning, Jeffrey L; Tallquist, Michelle; Buch, Thorsten; Oliveira-Martins, José B; Zhu, Caihong; Hermann, Mario; Wagner, Ulrich; Brink, Robert; Heikenwalder, Mathias; Aguzzi, Adriano.

Cell ; 150(1): 194-206, 2012 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-22770220

4.

An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.

Avar, Merve; Heinzer, Daniel; Thackray, Alana M; Liu, Yingjun; Hruska-Plochan, Marian; Sellitto, Stefano; Schaper, Elke; Pease, Daniel P; Yin, Jiang-An; Lakkaraju, Asvin Kk; Emmenegger, Marc; Losa, Marco; Chincisan, Andra; Hornemann, Simone; Polymenidou, Magdalini; Bujdoso, Raymond; Aguzzi, Adriano.

EMBO J ; 41(23): e112338, 2022 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-36254605

5.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin, Bernardo S; Bossaller, Lukas; De Nardo, Dominic; Ratter, Jacqueline M; Stutz, Andrea; Engels, Gudrun; Brenker, Christoph; Nordhoff, Mark; Mirandola, Sandra R; Al-Amoudi, Ashraf; Mangan, Matthew S; Zimmer, Sebastian; Monks, Brian G; Fricke, Martin; Schmidt, Reinhold E; Espevik, Terje; Jones, Bernadette; Jarnicki, Andrew G; Hansbro, Philip M; Busto, Patricia; Marshak-Rothstein, Ann; Hornemann, Simone; Aguzzi, Adriano; Kastenmüller, Wolfgang; Latz, Eicke.

Nat Immunol ; 15(8): 727-37, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24952505

6.

'Forward genetics' and the causes of ALS.

Aguzzi, Adriano.

Nat Rev Mol Cell Biol ; 20(2): 67, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30279566

7.

Lack of association between pandemic chilblains and SARS-CoV-2 infection.

Gehlhausen, Jeff R; Little, Alicia J; Ko, Christine J; Emmenegger, Marc; Lucas, Carolina; Wong, Patrick; Klein, Jon; Lu, Peiwen; Mao, Tianyang; Jaycox, Jillian; Wang, Eric; Ugwu, Nelson; Muenker, Cate; Mekael, Dilgash; Klein, Rhonda Q; Patrignelli, Robert; Antaya, Richard; McNiff, Jennifer; Damsky, William; Kamath, Kathy; Shon, John; Ring, Aaron M; Yildirim, Inci; Omer, Saad; Ko, Albert I; Aguzzi, Adriano; Iwasaki, Akiko.

Proc Natl Acad Sci U S A ; 119(9)2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-35217624

8.

Correction: Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins.

Emmenegger, Marc; Kumar, Sreedhar Saseendran; Emmenegger, Vishalini; Malinauskas, Tomas; Buettner, Thomas; Rose, Laura; Schierack, Peter; Sprinzl, Martin F; Sommer, Clemens J; Lackner, Karl J; Aguzzi, Adriano; Roggenbuck, Dirk; Frauenknecht, Katrin B M.

PLoS Pathog ; 18(2): e1010289, 2022 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-35108341

9.

Prions, prionoids and protein misfolding disorders.

Scheckel, Claudia; Aguzzi, Adriano.

Nat Rev Genet ; 19(7): 405-418, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29713012

10.

Prion topology and toxicity.

Aguzzi, Adriano; Steele, Andrew D.

Cell ; 137(6): 994-6, 2009 Jun 12.

Artigo em Inglês | MEDLINE | ID: mdl-19524502

11.

Mechanism of misfolding of the human prion protein revealed by a pathological mutation.

Sanz-Hernández, Máximo; Barritt, Joseph D; Sobek, Jens; Hornemann, Simone; Aguzzi, Adriano; De Simone, Alfonso.

Proc Natl Acad Sci U S A ; 118(12)2021 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-33731477

12.

Pericytes regulate vascular immune homeostasis in the CNS.

Török, Orsolya; Schreiner, Bettina; Schaffenrath, Johanna; Tsai, Hsing-Chuan; Maheshwari, Upasana; Stifter, Sebastian A; Welsh, Christina; Amorim, Ana; Sridhar, Sucheta; Utz, Sebastian G; Mildenberger, Wiebke; Nassiri, Sina; Delorenzi, Mauro; Aguzzi, Adriano; Han, May H; Greter, Melanie; Becher, Burkhard; Keller, Annika.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-33653955

13.

Prion protein and prion disease at a glance.

Zhu, Caihong; Aguzzi, Adriano.

J Cell Sci ; 134(17)2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-34472604

14.

Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.

Heinzer, Daniel; Avar, Merve; Pease, Daniel Patrick; Dhingra, Ashutosh; Yin, Jiang-An; Schaper, Elke; Dogançay, Berre; Emmenegger, Marc; Spinelli, Anna; Maggi, Kevin; Chincisan, Andra; Mead, Simon; Hornemann, Simone; Heutink, Peter; Aguzzi, Adriano.

PLoS Pathog ; 17(10): e1010013, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34705895

15.

The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.

Kamali-Jamil, Razieh; Vázquez-Fernández, Ester; Tancowny, Brian; Rathod, Vineet; Amidian, Sara; Wang, Xiongyao; Tang, Xinli; Fang, Andrew; Senatore, Assunta; Hornemann, Simone; Dudas, Sandor; Aguzzi, Adriano; Young, Howard S; Wille, Holger.

PLoS Pathog ; 17(6): e1009628, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34061899

16.

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins.

Emmenegger, Marc; Kumar, Sreedhar Saseendran; Emmenegger, Vishalini; Malinauskas, Tomas; Buettner, Thomas; Rose, Laura; Schierack, Peter; Sprinzl, Martin F; Sommer, Clemens J; Lackner, Karl J; Aguzzi, Adriano; Roggenbuck, Dirk; Frauenknecht, Katrin B M.

PLoS Pathog ; 17(12): e1010118, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34860860

17.

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue.

Voigt, Fabian F; Kirschenbaum, Daniel; Platonova, Evgenia; Pagès, Stéphane; Campbell, Robert A A; Kastli, Rahel; Schaettin, Martina; Egolf, Ladan; van der Bourg, Alexander; Bethge, Philipp; Haenraets, Karen; Frézel, Noémie; Topilko, Thomas; Perin, Paola; Hillier, Daniel; Hildebrand, Sven; Schueth, Anna; Roebroeck, Alard; Roska, Botond; Stoeckli, Esther T; Pizzala, Roberto; Renier, Nicolas; Zeilhofer, Hanns Ulrich; Karayannis, Theofanis; Ziegler, Urs; Batti, Laura; Holtmaat, Anthony; Lüscher, Christian; Aguzzi, Adriano; Helmchen, Fritjof.

Nat Methods ; 16(11): 1105-1108, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31527839

18.

Genome-wide transcriptomics identifies an early preclinical signature of prion infection.

Sorce, Silvia; Nuvolone, Mario; Russo, Giancarlo; Chincisan, Andra; Heinzer, Daniel; Avar, Merve; Pfammatter, Manuela; Schwarz, Petra; Delic, Mirzet; Müller, Micha; Hornemann, Simone; Sanoudou, Despina; Scheckel, Claudia; Aguzzi, Adriano.

PLoS Pathog ; 16(6): e1008653, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32598380

19.

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

Hopfner, Franziska; Tietz, Anja K; Ruf, Viktoria C; Ross, Owen A; Koga, Shunsuke; Dickson, Dennis; Aguzzi, Adriano; Attems, Johannes; Beach, Thomas; Beller, Allison; Cheshire, William P; van Deerlin, Vivianna; Desplats, Paula; Deuschl, Günther; Duyckaerts, Charles; Ellinghaus, David; Evsyukov, Valentin; Flanagan, Margaret Ellen; Franke, Andre; Frosch, Matthew P; Gearing, Marla; Gelpi, Ellen; van Gerpen, Jay A; Ghetti, Bernardino; Glass, Jonathan D; Grinberg, Lea T; Halliday, Glenda; Helbig, Ingo; Höllerhage, Matthias; Huitinga, Inge; Irwin, David John; Keene, Dirk C; Kovacs, Gabor G; Lee, Edward B; Levin, Johannes; Martí, Maria J; Mackenzie, Ian; McKeith, Ian; Mclean, Catriona; Mollenhauer, Brit; Neumann, Manuela; Newell, Kathy L; Pantelyat, Alex; Pendziwiat, Manuela; Peters, Annette; Molina Porcel, Laura; Rabano, Alberto; Matej, Radoslav; Rajput, Alex; Rajput, Ali.

Mov Disord ; 37(10): 2110-2121, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-35997131

20.

Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network.

McKenzie, Neil; Piconi, Gabriele; Culeux, Audrey; Hammarin, Anna-Lena; Stergiou, Christos; Tzartos, Socrates; Versleijen, Alexandra A M; van de Geer, Jacqueline; Cras, Patrick; Cardone, Franco; Ladogana, Anna; Mannana, Angela; Rossi, Marcello; Bongianni, Matilde; Perra, Daniela; Regelsberger, Guenther; Klotz, Sigrid; Hornemann, Simone; Aguzzi, Adriano; Schmitz, Matthias; Andrews, Mary; Burns, Kimberley; Haïk, Stéphane; Ruiz-García, Raquel; Verner-Carlsson, Jenny; Tzartos, John; Verbeek, Marcel M; De Vil, Bart; Poleggi, Anna; Parchi, Piero; Zanusso, Gianluigi; Gelpi, Ellen; Frontzek, Karl; Reimann, Regina; Hermann, Peter; Zerr, Inga; Pal, Suvankar; Green, Alison.

Eur J Neurol ; 29(8): 2431-2438, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35524506

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