Detalhe da pesquisa
1.
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Bioorg Med Chem Lett
; 25(5): 1047-52, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25655723
2.
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.
Bioorg Med Chem Lett
; 24(5): 1303-6, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513042
3.
CEP-26401 (irdabisant), a potent and selective histamine H3 receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities.
J Pharmacol Exp Ther
; 340(1): 124-33, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22001260
4.
Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.
Bioorg Med Chem Lett
; 22(6): 2151-3, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365751
5.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists.
Bioorg Med Chem Lett
; 22(12): 4198-202, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22617490
6.
Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H(3) receptor inverse agonists.
Bioorg Med Chem Lett
; 22(2): 1073-7, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197136
7.
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists.
Bioorg Med Chem Lett
; 22(8): 2807-10, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22450133
8.
Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.
Bioorg Med Chem Lett
; 22(1): 186-9, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153342
9.
Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.
Bioorg Med Chem Lett
; 22(4): 1546-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22297111
10.
4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity.
Bioorg Med Chem Lett
; 22(4): 1504-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22290075
11.
4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists.
Bioorg Med Chem Lett
; 22(1): 194-8, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22142542
12.
Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Bioorg Med Chem Lett
; 22(11): 3751-3, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22546675
13.
Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
Bioorg Med Chem Lett
; 22(1): 133-7, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169263
14.
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.
Bioorg Med Chem Lett
; 22(3): 1421-6, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22226656
15.
Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists.
Bioorg Med Chem Lett
; 22(1): 120-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153937
16.
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.
Bioorg Med Chem
; 20(12): 3880-6, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22578490
17.
2,7-Disubstituted-pyrrolotriazine kinase inhibitors with an unusually high degree of reactive metabolite formation.
Chem Res Toxicol
; 24(11): 1994-2003, 2011 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22023349
18.
Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 21(20): 6126-30, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21906941
19.
Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 21(23): 7076-80, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22014551
20.
Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors.
Bioorg Med Chem Lett
; 21(13): 3877-80, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21632243