Pesquisa | BVS Violência e Saúde

1.

Embracing cancer complexity: Hallmarks of systemic disease.

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas.

Cell ; 187(7): 1589-1616, 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38552609

2.

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.

Wang, Man-Tzu; Holderfield, Matthew; Galeas, Jacqueline; Delrosario, Reyno; To, Minh D; Balmain, Allan; McCormick, Frank.

Cell ; 163(5): 1237-1251, 2015 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-26590425

3.

KRAS4A directly regulates hexokinase 1.

Amendola, Caroline R; Mahaffey, James P; Parker, Seth J; Ahearn, Ian M; Chen, Wei-Ching; Zhou, Mo; Court, Helen; Shi, Jie; Mendoza, Sebastian L; Morten, Michael J; Rothenberg, Eli; Gottlieb, Eyal; Wadghiri, Youssef Z; Possemato, Richard; Hubbard, Stevan R; Balmain, Allan; Kimmelman, Alec C; Philips, Mark R.

Nature ; 576(7787): 482-486, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31827279

4.

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.

Adorno, Maddalena; Cordenonsi, Michelangelo; Montagner, Marco; Dupont, Sirio; Wong, Christine; Hann, Byron; Solari, Aldo; Bobisse, Sara; Rondina, Maria Beatrice; Guzzardo, Vincenza; Parenti, Anna R; Rosato, Antonio; Bicciato, Silvio; Balmain, Allan; Piccolo, Stefano.

Cell ; 137(1): 87-98, 2009 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-19345189

5.

Air pollution's role in the promotion of lung cancer.

Balmain, Allan.

Nature ; 616(7955): 35-36, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-37020001

6.

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

Westcott, Peter M K; Halliwill, Kyle D; To, Minh D; Rashid, Mamunur; Rust, Alistair G; Keane, Thomas M; Delrosario, Reyno; Jen, Kuang-Yu; Gurley, Kay E; Kemp, Christopher J; Fredlund, Erik; Quigley, David A; Adams, David J; Balmain, Allan.

Nature ; 517(7535): 489-92, 2015 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-25363767

7.

Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

Wong, Christine E; Yu, Jennifer S; Quigley, David A; To, Minh D; Jen, Kuang-Yu; Huang, Phillips Y; Del Rosario, Reyno; Balmain, Allan.

Genes Dev ; 27(6): 670-82, 2013 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-23512660

8.

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.

Wang, Yunyuan V; Leblanc, Mathias; Fox, Norma; Mao, Jian-Hua; Tinkum, Kelsey L; Krummel, Kurt; Engle, Dannielle; Piwnica-Worms, David; Piwnica-Worms, Helen; Balmain, Allan; Kaushansky, Kenneth; Wahl, Geoffrey M.

Genes Dev ; 25(13): 1426-38, 2011 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-21724834

9.

Peto's paradox revisited: black box vs mechanistic approaches to understanding the roles of mutations and promoting factors in cancer.

Balmain, Allan.

Eur J Epidemiol ; 2022 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-36512199

10.

Identification of Hipk2 as an essential regulator of white fat development.

Sjölund, Jonas; Pelorosso, Facundo G; Quigley, David A; DelRosario, Reyno; Balmain, Allan.

Proc Natl Acad Sci U S A ; 111(20): 7373-8, 2014 May 20.

Artigo em Inglês | MEDLINE | ID: mdl-24785298

11.

Cellular reprogramming in skin cancer.

Song, Ihn Young; Balmain, Allan.

Semin Cancer Biol ; 32: 32-9, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24721247

12.

The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.

Adams, Cassandra J; Yu, Jennifer S; Mao, Jian-Hua; Jen, Kuang-Yu; Costes, Sylvain V; Wade, Mark; Shoemake, Jocelyn; Aina, Olulanu H; Del Rosario, Reyno; Menchavez, Phuong Thuy; Cardiff, Robert D; Wahl, Geoffrey M; Balmain, Allan.

Mol Carcinog ; 55(9): 1387-96, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-26310697

13.

Keratin 16 regulates innate immunity in response to epidermal barrier breach.

Lessard, Juliane C; Piña-Paz, Sylvia; Rotty, Jeremy D; Hickerson, Robyn P; Kaspar, Roger L; Balmain, Allan; Coulombe, Pierre A.

Proc Natl Acad Sci U S A ; 110(48): 19537-42, 2013 Nov 26.

Artigo em Inglês | MEDLINE | ID: mdl-24218583

14.

Systems genetics analysis of cancer susceptibility: from mouse models to humans.

Quigley, David; Balmain, Allan.

Nat Rev Genet ; 10(9): 651-7, 2009 09.

Artigo em Inglês | MEDLINE | ID: mdl-19636343

15.

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

Mao, Jian-Hua; Wu, Di; Perez-Losada, Jesus; Jiang, Tao; Li, Qian; Neve, Richard M; Gray, Joe W; Cai, Wei-Wen; Balmain, Allan.

Cancer Cell ; 11(2): 161-73, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17292827

16.

Genetic architecture of mouse skin inflammation and tumour susceptibility.

Quigley, David A; To, Minh D; Pérez-Losada, Jesús; Pelorosso, Facundo G; Mao, Jian-Hua; Nagase, Hiroki; Ginzinger, David G; Balmain, Allan.

Nature ; 458(7237): 505-8, 2009 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-19136944

17.

A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.

To, Minh D; Perez-Losada, Jesus; Mao, Jian-Hua; Hsu, Jeff; Jacks, Tyler; Balmain, Allan.

Nat Genet ; 38(8): 926-30, 2006 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-16823377

18.

Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Jen, Kuang-Yu; Song, Ihn Young; Banta, Karl Luke; Wu, Di; Mao, Jian-Hua; Balmain, Allan.

Blood ; 119(3): 805-9, 2012 Jan 19.

Artigo em Inglês | MEDLINE | ID: mdl-22117044

19.

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

Saunders, Sean P; Goh, Christabelle S M; Brown, Sara J; Palmer, Colin N A; Porter, Rebecca M; Cole, Christian; Campbell, Linda E; Gierlinski, Marek; Barton, Geoffrey J; Schneider, Georg; Balmain, Allan; Prescott, Alan R; Weidinger, Stephan; Baurecht, Hansjörg; Kabesch, Michael; Gieger, Christian; Lee, Young-Ae; Tavendale, Roger; Mukhopadhyay, Somnath; Turner, Stephen W; Madhok, Vishnu B; Sullivan, Frank M; Relton, Caroline; Burn, John; Meggitt, Simon; Smith, Catherine H; Allen, Michael A; Barker, Jonathan N W N; Reynolds, Nick J; Cordell, Heather J; Irvine, Alan D; McLean, W H Irwin; Sandilands, Aileen; Fallon, Padraic G.

J Allergy Clin Immunol ; 132(5): 1121-9, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-24084074

20.

Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression.

Reeves, Melissa Q; Balmain, Allan.

Cold Spring Harb Perspect Med ; 14(3)2024 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-38052482

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