Pesquisa | BVS Violência e Saúde

1.

The next generation of CRISPR-Cas technologies and applications.

Pickar-Oliver, Adrian; Gersbach, Charles A.

Nat Rev Mol Cell Biol ; 20(8): 490-507, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31147612

2.

Unwinding the Role of FACT in Cas9-based Genome Editing.

Cosgrove, Brian D; Gersbach, Charles A.

Mol Cell ; 79(3): 365-367, 2020 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-32763224

3.

Multicenter integrated analysis of noncoding CRISPRi screens.

Yao, David; Tycko, Josh; Oh, Jin Woo; Bounds, Lexi R; Gosai, Sager J; Lataniotis, Lazaros; Mackay-Smith, Ava; Doughty, Benjamin R; Gabdank, Idan; Schmidt, Henri; Guerrero-Altamirano, Tania; Siklenka, Keith; Guo, Katherine; White, Alexander D; Youngworth, Ingrid; Andreeva, Kalina; Ren, Xingjie; Barrera, Alejandro; Luo, Yunhai; Yardimci, Galip Gürkan; Tewhey, Ryan; Kundaje, Anshul; Greenleaf, William J; Sabeti, Pardis C; Leslie, Christina; Pritykin, Yuri; Moore, Jill E; Beer, Michael A; Gersbach, Charles A; Reddy, Timothy E; Shen, Yin; Engreitz, Jesse M; Bassik, Michael C; Reilly, Steven K.

Nat Methods ; 21(4): 723-734, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38504114

4.

The NIH Somatic Cell Genome Editing program.

Saha, Krishanu; Sontheimer, Erik J; Brooks, P J; Dwinell, Melinda R; Gersbach, Charles A; Liu, David R; Murray, Stephen A; Tsai, Shengdar Q; Wilson, Ross C; Anderson, Daniel G; Asokan, Aravind; Banfield, Jillian F; Bankiewicz, Krystof S; Bao, Gang; Bulte, Jeff W M; Bursac, Nenad; Campbell, Jarryd M; Carlson, Daniel F; Chaikof, Elliot L; Chen, Zheng-Yi; Cheng, R Holland; Clark, Karl J; Curiel, David T; Dahlman, James E; Deverman, Benjamin E; Dickinson, Mary E; Doudna, Jennifer A; Ekker, Stephen C; Emborg, Marina E; Feng, Guoping; Freedman, Benjamin S; Gamm, David M; Gao, Guangping; Ghiran, Ionita C; Glazer, Peter M; Gong, Shaoqin; Heaney, Jason D; Hennebold, Jon D; Hinson, John T; Khvorova, Anastasia; Kiani, Samira; Lagor, William R; Lam, Kit S; Leong, Kam W; Levine, Jon E; Lewis, Jennifer A; Lutz, Cathleen M; Ly, Danith H; Maragh, Samantha; McCray, Paul B.

Nature ; 592(7853): 195-204, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33828315

5.

Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.

Barrangou, Rodolphe; Gersbach, Charles A.

Mol Cell ; 65(4): 582-584, 2017 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-28212745

6.

AP-1 subunits converge promiscuously at enhancers to potentiate transcription.

Seo, Jungkyun; Koçak, D Dewran; Bartelt, Luke C; Williams, Courtney A; Barrera, Alejandro; Gersbach, Charles A; Reddy, Timothy E.

Genome Res ; 31(4): 538-550, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33674350

7.

Transgenic mice for in vivo epigenome editing with CRISPR-based systems.

Gemberling, Matthew P; Siklenka, Keith; Rodriguez, Erica; Tonn-Eisinger, Katherine R; Barrera, Alejandro; Liu, Fang; Kantor, Ariel; Li, Liqing; Cigliola, Valentina; Hazlett, Mariah F; Williams, Courtney A; Bartelt, Luke C; Madigan, Victoria J; Bodle, Josephine C; Daniels, Heather; Rouse, Douglas C; Hilton, Isaac B; Asokan, Aravind; Ciofani, Maria; Poss, Kenneth D; Reddy, Timothy E; West, Anne E; Gersbach, Charles A.

Nat Methods ; 18(8): 965-974, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34341582

8.

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Housden, Benjamin E; Muhar, Matthias; Gemberling, Matthew; Gersbach, Charles A; Stainier, Didier Y R; Seydoux, Geraldine; Mohr, Stephanie E; Zuber, Johannes; Perrimon, Norbert.

Nat Rev Genet ; 18(1): 24-40, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27795562

9.

Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science.

Abdeen, Amr A; Cosgrove, Brian D; Gersbach, Charles A; Saha, Krishanu.

Annu Rev Biomed Eng ; 23: 493-516, 2021 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-33909475

10.

Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy.

Pickar-Oliver, Adrian; Gough, Veronica; Bohning, Joel D; Liu, Siyan; Robinson-Hamm, Jacqueline N; Daniels, Heather; Majoros, William H; Devlin, Garth; Asokan, Aravind; Gersbach, Charles A.

Mol Ther ; 29(11): 3243-3257, 2021 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-34509668

11.

Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems.

Carullo, Nancy V N; Phillips Iii, Robert A; Simon, Rhiana C; Soto, Salomon A Roman; Hinds, Jenna E; Salisbury, Aaron J; Revanna, Jasmin S; Bunner, Kendra D; Ianov, Lara; Sultan, Faraz A; Savell, Katherine E; Gersbach, Charles A; Day, Jeremy J.

Nucleic Acids Res ; 48(17): 9550-9570, 2020 09 25.

Artigo em Inglês | MEDLINE | ID: mdl-32810208

12.

Editing the Epigenome: Reshaping the Genomic Landscape.

Holtzman, Liad; Gersbach, Charles A.

Annu Rev Genomics Hum Genet ; 19: 43-71, 2018 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-29852072

13.

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.

McDowell, Ian C; Barrera, Alejandro; D'Ippolito, Anthony M; Vockley, Christopher M; Hong, Linda K; Leichter, Sarah M; Bartelt, Luke C; Majoros, William H; Song, Lingyun; Safi, Alexias; Koçak, D Dewran; Gersbach, Charles A; Hartemink, Alexander J; Crawford, Gregory E; Engelhardt, Barbara E; Reddy, Timothy E.

Genome Res ; 28(9): 1272-1284, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30097539

14.

Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.

Adkar, Shaunak S; Wu, Chia-Lung; Willard, Vincent P; Dicks, Amanda; Ettyreddy, Adarsh; Steward, Nancy; Bhutani, Nidhi; Gersbach, Charles A; Guilak, Farshid.

Stem Cells ; 37(1): 65-76, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30378731

15.

AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.

Nance, Michael E; Shi, Ruicheng; Hakim, Chady H; Wasala, Nalinda B; Yue, Yongping; Pan, Xiufang; Zhang, Tracy; Robinson, Carolyn A; Duan, Sean X; Yao, Gang; Yang, N Nora; Chen, Shi-Jie; Wagner, Kathryn R; Gersbach, Charles A; Duan, Dongsheng.

Mol Ther ; 27(9): 1568-1585, 2019 09 04.

Artigo em Inglês | MEDLINE | ID: mdl-31327755

16.

Editing the epigenome: technologies for programmable transcription and epigenetic modulation.

Thakore, Pratiksha I; Black, Joshua B; Hilton, Isaac B; Gersbach, Charles A.

Nat Methods ; 13(2): 127-37, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26820547

17.

From CRISPR scissors to virus sensors.

Kocak, D Dewran; Gersbach, Charles A.

Nature ; 557(7704): 168-169, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29730672

18.

Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies.

Manandhar, Dinesh; Song, Lingyun; Kabadi, Ami; Kwon, Jennifer B; Edsall, Lee E; Ehrlich, Melanie; Tsumagari, Koji; Gersbach, Charles A; Crawford, Gregory E; Gordân, Raluca.

Nucleic Acids Res ; 45(20): 11684-11699, 2017 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-28977539

19.

Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.

Pathak, Gopal P; Spiltoir, Jessica I; Höglund, Camilla; Polstein, Lauren R; Heine-Koskinen, Sari; Gersbach, Charles A; Rossi, Jari; Tucker, Chandra L.

Nucleic Acids Res ; 45(20): e167, 2017 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-28431041

20.

Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing.

Moutos, Franklin T; Glass, Katherine A; Compton, Sarah A; Ross, Alison K; Gersbach, Charles A; Guilak, Farshid; Estes, Bradley T.

Proc Natl Acad Sci U S A ; 113(31): E4513-22, 2016 08 02.

Artigo em Inglês | MEDLINE | ID: mdl-27432980

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