RESUMO
OBJECTIVE: To analyze genome-wide studies devoted to polymorphisms of factors of anterior abdominal wall hernias, to study the association of the most common polymorphism In Russian population. MATERIAL AND METHODS: Searching for literature data was carried out in the RSCI and PubMed databases. We enrolled national and foreign reports. The study on Russian population included 577 people. RESULTS: We found 5 genome-wide studies performed by foreign authors. We identified the loci responsible for genetic predisposition to inguinal hernias: WT1, EFEMP1, EBF2 and ADAMTS6. The Japanese scientists revealed an important role of loci TGFB2, RNA5SP214/VGLL2, LOC646588, HMCN2, ATP5F1CP1/CDKN3. In other studies, loci 1q41 (ZC3H11B), 2p16.1 (EFEMP1), 6p22.1 (MHC region), 7q33 (CALD1) and 11p13 (WT1) determined different hernias. The EFEMP1 gene polymorphism was among genes most associated with anterior abdominal wall hernias in all studies. Analysis of this polymorphism In Russian population revealed significant association with anterior abdominal wall hernias. CONCLUSION: The obtained data on target correction of DNA chains can significantly reduce the incidence of anterior abdominal wall hernias. In turn, this will significantly reduce the cost of surgical treatment and risk of complications with recurrences of hernias. Moreover, identifying the most associated polymorphisms may be valuable to determine the most appropriate surgical treatment.
Assuntos
Predisposição Genética para Doença , Humanos , Federação Russa/epidemiologia , Estudo de Associação Genômica Ampla/métodos , Hérnia Abdominal/genética , Hérnia Abdominal/cirurgia , Hérnia Abdominal/epidemiologia , Polimorfismo GenéticoRESUMO
Branched oligohexamethyleneguanidine hydrochloride (branched OHMG-HC) possesses high biocidal activity. This study aimed at evaluating the pharmacokinetics of branched OHMG-HC and is mandatory for obtaining permission to conduct clinical studies. The thermal activation method was used to obtain radioactive-labeled drugs for the investigation of substance distribution in various tissues of experimental animals (rats and rabbits). Substance administration was carried out both orally (a dose was split into two equal volumes that were applied to buccal zones of the oral cavities of the animals) and intravenously to get a clear pharmacokinetic profile. In this research, the drug was applied in the concentration of 0.77 mg/kg with the addition of 0.037 mg/kg 3H-OHMG for rats, and 0.42 mg/kg with the addition of 0.015 mg/kg 3H-OHMG for Chinchilla rabbits. The selected samples of blood, organs, and urine underwent alkaline mineralization. A quantitative determination of 3H-OHMG was carried out using a liquid ß-, γ-counter according to the level of scintillation in the sample. Branched OHMG-HC displayed uniform distribution within all main organs and tissues upon oral administration. The highest concentrations were found in liver and kidney tissues, whereas the lowest in blood, cardiac muscle tissue, and brain. The closeness of the fabs values obtained from different animals (24.5% for rats and 29.0% for rabbits) demonstrated the absence of the species specificity in response to the pharmaceutical substance. The main parameters of excretion were established, and the half-life time was estimated to be 15 h.
Assuntos
Gengivite , Estomatite , Administração Oral , Animais , Fígado , Coelhos , Ratos , Distribuição TecidualRESUMO
OBJECTIVE: To define the indication for preventive mesh implantation in patients scheduled for laparotomy. MATERIAL AND METHODS: There were 108 patients divided into the control (52 patients without anterior abdominal wall hernia) and the main (56 patients with ventral hernia) groups. RESULTS: Predominance of collagen type III over type I was observed in patients older 60 years in the main group. The maximum ratio of collagen types I and III was 1.4 in the main group. The minimum number of inter-fiber spaces (n=5) was noted in patients aged 30-40 years. The maximum density of connective tissue was 250 pixels per inch. CONCLUSION: Analysis of connective tissue structures revealed some important age-related features and markers of connective tissue dysplasia in the main group. An indication for preventive mesh implantation in patients scheduled for laparotomy was determined.
Assuntos
Colágeno/análise , Doenças do Tecido Conjuntivo/complicações , Hérnia Ventral/prevenção & controle , Hérnia Incisional/prevenção & controle , Laparotomia/efeitos adversos , Telas Cirúrgicas , Parede Abdominal/patologia , Parede Abdominal/cirurgia , Adulto , Tecido Conjuntivo/química , Tecido Conjuntivo/patologia , Doenças do Tecido Conjuntivo/patologia , Hérnia Ventral/etiologia , Hérnia Ventral/patologia , Herniorrafia/métodos , Humanos , Hérnia Incisional/etiologia , Hérnia Incisional/patologia , Pessoa de Meia-IdadeRESUMO
AIM: To analyze collagen types ratio in skin and aponeurosis in order to predict postoperative ventral hernias. MATERIAL AND METHODS: The trial included 141 patients for the period 2012-2015. Group I (n=65) of patients without ventral hernias was divided into subgroup AI (primary operation, n=41) and BI (re-operation, n=24). Group II consisted of 76 patients with ventral hernias. We performed histological examination of skin and aponeurosis to define the collagen structure of connective tissue. RESULTS: There were significant differences between collagen type I/III ratio in skin (2.81±0.52 in group I vs. 1.13±0.48 in group II) and aponeurosis (2.69±0.41 vs. 1.09±0.21, respectively, p≤0.05). We revealed strong direct correlation (r=+0.92) between aponeurosis and skin specimens in one group. Collagen type I level was 73.81±2.74% in subgroup AI and 72.03±2.47% in subgroup BI. Collagen type I was predominant (p≤0.05). CONCLUSION: In patients with ventral hernias collagen type I/III ratio in skin is 2.54 times lower than in patients without hernias. Significant correlation of collagen types in skin and aponeurosis (r= +0.92) allows to predict the risk of postoperative ventral hernias on basis of skin fragment.
Assuntos
Aponeurose/patologia , Colágeno Tipo III/análise , Colágeno Tipo I/análise , Hérnia Ventral , Hérnia Incisional , Reoperação/efeitos adversos , Pele/patologia , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Parede Abdominal/patologia , Parede Abdominal/cirurgia , Feminino , Hérnia Ventral/diagnóstico , Hérnia Ventral/etiologia , Hérnia Ventral/patologia , Hérnia Ventral/prevenção & controle , Humanos , Hérnia Incisional/diagnóstico , Hérnia Incisional/patologia , Hérnia Incisional/prevenção & controle , Masculino , Microscopia de Polarização/métodos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Reoperação/métodos , Medição de Risco/métodosRESUMO
AIM: To study neocollagenogenesis after implantation of polypropylene endoprosthesis and polypropylene combined with polylactic acid endoprosthesis on background of «potassium orotate¼ administration. MATERIAL AND METHODS: We used two different types of endoprosthesis in the experiment. The first type was made of just polypropylene, the second type was made of polypropylene combined with polylactic acid. Histological examination was performed using polarizing microscopy. Collagen types I and III ratio in connective tissue around the prosthesis was analyzed according to the color that was individual for each type. RESULTS: The results were significantly better in case of collagenogenesis stimulation with Potassium orotate within 30 days and later for one type of endoprosthesis. Also we revealed that collagenogenesis and paraprosthesis capsule formation were more active in case of combined endoprosthesis. We revealed stimulating action of «Potassium Orotate¼ for collegenogenesis process, this fact was proved by increased collagen I/III ratio. CONCLUSION: Optimization of collagenogenesis was based on persistent 1,37-fold increase of collagen I/III ratio in case of combined endoprosthesis after 90 days. It was manifested by accelerated formation of connective tissue capsule and facilitated early isolation of the implant from surrounding tissues.
Assuntos
Colágeno/metabolismo , Tecido Conjuntivo , Implantes Experimentais , Ácido Orótico , Poliésteres/farmacologia , Polipropilenos/farmacologia , Implantação de Prótese/instrumentação , Regeneração/efeitos dos fármacos , Experimentação Animal , Animais , Materiais Biocompatíveis/metabolismo , Materiais Biocompatíveis/farmacologia , Disponibilidade Biológica , Tecido Conjuntivo/efeitos dos fármacos , Tecido Conjuntivo/metabolismo , Tecido Conjuntivo/patologia , Camundongos , Ácido Orótico/metabolismo , Ácido Orótico/farmacologia , Compostos de Potássio/metabolismo , Compostos de Potássio/farmacologia , Implantação de Prótese/métodos , Regeneração/fisiologiaRESUMO
The aim of the study was to learn the degree of biocompatibility of synthetic herniological prostheses «Progrip¼, with collagen-stimulating effect of ascorbic acid on the growth of connective tissue in the experiment. We examined characteristics of collagenogenesis in the anterior abdominal wall depending on the effect of vitamin C using the method of polarization microscopy. We suggest a new way to stimulate reparation process by ascorbic acid which would help to optimize forming functionally matured structures of connective tissue of the anterior abdominal wall surrounding endoprosthesis. Due to the results of our investigation it has been clear that modification effect of vitamin C is positive for synthesis of collagen in the periprosthetic capsule for any type of endoprosthesis. It has been proves by statistically reliable increase in ratio of collagen types I and III when vitamin C is used in the diet of experimental animals.
Assuntos
Ácido Ascórbico/farmacologia , Colágeno Tipo III/biossíntese , Colágeno Tipo I/biossíntese , Implantes Experimentais , Animais , Feminino , Masculino , CamundongosRESUMO
Dihydroquercetin effects on the tone of isolated segments of the portal vein of rats were studied. Dihydroquercetin did not modify the basal venous tone, but reduced the amplitude of contractions induced by KCl and norepinephrine hydrotartrate.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Veia Porta/efeitos dos fármacos , Quercetina/análogos & derivados , Vasoconstrição/efeitos dos fármacos , Animais , Técnicas In Vitro , Masculino , Contração Muscular/efeitos dos fármacos , Músculo Liso Vascular/efeitos dos fármacos , Músculo Liso Vascular/fisiologia , Norepinefrina , Veia Porta/fisiologia , Cloreto de Potássio , Quercetina/farmacologia , Ratos , Ratos WistarRESUMO
Nowadays, the use of synthetic prosthesis is obligatory method in surgical treatment of large and giant ventral hernias. We have fulfilled comparative investigation of the dynamics of collagen Type I to Type III ratio in paraprosthetic region in mice when using implants, Esphyl - polyethylene, Ecophlon - polytetrafluorethylene, and Uniflex - polyvinylidenfluoride, with a one- and two-time introduction of cultured fibroblasts into paraprosthetic region at different times after implantations and without the introduction. Use of Sirius Red dye staining and polarization microscopy revealed that, in short period (10 days after endoprosthesis implantation), the implication of fibroblasts and the number of implications did not affect the collagen Types ratio. In later stages (30-60 days after endoprosthesis implantation) a significant increase in collagen Type I was observed when using all the materials. The ratio of collagen Type I to Type III was maximal at all stages of the experiment in the case of the implant Uniflex. Double implication of exogenous fibroblasts accelerated the increase in the collagen Type I to Type III ratio to a greater extent.
Assuntos
Colágeno Tipo III/biossíntese , Colágeno Tipo I/biossíntese , Embrião de Mamíferos/citologia , Fibroblastos/transplante , Hérnia Ventral/cirurgia , Polietileno/farmacologia , Politetrafluoretileno/farmacologia , Polivinil/farmacologia , Próteses e Implantes , Animais , Fibroblastos/citologia , Hérnia Ventral/metabolismo , Teste de Materiais/métodos , Camundongos , Transplante HomólogoRESUMO
The synthetic mesh is widely used for treatment of hernias. We conducted a comparative study of the morphological pattern of inflammation, the cellular composition of tissues and dynamics of scar formation in mice when using implants "Esfil" and "Unifleks" under influence of single and double injection of cultured fibroblast and without such injection to the region of stents location. A more pronounced inflammatory reaction during the study period of investigation was observed in the case of "Esfil". In the late period of the study, a higher percentage of fibroblasts was observed in the case of the prosthesis "Unifleks" compared to the prosthesis "Esfil". Injection of cultured fibroblasts modifies the curve of the dynamics of the inflammatory process by making it smoother in the case of both prostheses. So, more preferred is the use of prostheses "Unifleks".
Assuntos
Movimento Celular/efeitos dos fármacos , Tecido Conjuntivo/efeitos dos fármacos , Fibroblastos/citologia , Polipropilenos/farmacologia , Politetrafluoretileno/farmacologia , Animais , Materiais Biocompatíveis/farmacologia , Movimento Celular/imunologia , Transplante de Células , Células Cultivadas , Cicatriz/imunologia , Cicatriz/patologia , Tecido Conjuntivo/imunologia , Tecido Conjuntivo/patologia , Fibroblastos/imunologia , Herniorrafia , Humanos , Inflamação/imunologia , Inflamação/patologia , Linfócitos/citologia , Linfócitos/imunologia , Macrófagos/citologia , Macrófagos/imunologia , Masculino , Camundongos , Próteses e Implantes/efeitos adversos , Implantação de Prótese , Telas Cirúrgicas/efeitos adversosRESUMO
The results of experimental and clinical studies for the comparative evaluation of implants used in herniology of polytetrafluoroethylene (PTFE) and polyvinylidene fluoride (PVDF) are presented. Experimental investigations conducted on 200 mice, which in the anterior abdominal wall mesh prosthesis implanted. All animals, regardless of the type of implanted prosthesis, deduced from the experiment at 10, 30 th and 60 th day. Histological investigation of the submissions received. The clinical part is based on an analysis of surgical treatment results of postoperative abdominal wall hernia (POGBS) in 121 patients during the period from 2003 to 2011 patients were divided into 2 groups. The control group included 73 patients who were operated during the period 2005-2007, used PTFE graft "Ecoflon", in the main - 48 patients who from 2008 to 2011 the prosthesis was implanted PVDF - "Uniflex" firm "Linteks". In each group, selected patients whom have examined the profile of cytokines. The results of the studies found that both the material cause marked inflammatory reaction with a characteristic stepwise increased levels of proinflammatory and antiinflammatory cytokines, the dynamics of cytokines indicative of a less pronounced local inflammatory reaction to the prosthesis from the PVDF. In the application of the implant "Uniflex" a lower incidence of exudative complications in comparison with that when using the prosthesis "Ecoflon" it is preferable in clinical use.
Assuntos
Citocinas/sangue , Hérnia Ventral/cirurgia , Inflamação/sangue , Inflamação/etiologia , Implantação de Prótese/efeitos adversos , Telas Cirúrgicas/efeitos adversos , Animais , Biomarcadores/sangue , Humanos , Camundongos , Politetrafluoretileno , Polivinil , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/etiologiaRESUMO
Venous hypertension and swelling of the hind limbs was demonstrated to develop in rat model of chronic venous insufficiency. It was found that 14-day course of dihydroquercetin (50 mg/kg) and lipoic acid (50 mg/kg) administered intragastrically prevented the increase in hind limb volume and reduced the severity of edema of rat muscle tissue in chronic venous insufficiency.
Assuntos
Antioxidantes/farmacologia , Quercetina/análogos & derivados , Ácido Tióctico/farmacologia , Insuficiência Venosa/tratamento farmacológico , Animais , Doença Crônica , Edema/etiologia , Edema/prevenção & controle , Membro Posterior/irrigação sanguínea , Membro Posterior/patologia , Masculino , Músculo Esquelético/irrigação sanguínea , Músculo Esquelético/patologia , Quercetina/farmacologia , Ratos , Ratos Wistar , Estatísticas não Paramétricas , Insuficiência Venosa/complicaçõesRESUMO
A hepatoprotective effect of thiophan was studied on the model of carbon tetrachloride-induced hepatitis in rats. Therapeutic administration of thiophan repairs the antitoxic function of liver, normalizes cytolysis marker activity, and improves the synthetic function of liver and the carbohydrate and lipid metabolism. The hepatoprotective activity of thiophan is similar to effect of silimarin.
Assuntos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Hepatite Animal/tratamento farmacológico , Fígado/efeitos dos fármacos , Substâncias Protetoras/uso terapêutico , Tiofenos/uso terapêutico , Alanina Transaminase/análise , Animais , Antioxidantes/administração & dosagem , Antioxidantes/uso terapêutico , Aspartato Aminotransferases/análise , Bilirrubina/análise , Metabolismo dos Carboidratos/efeitos dos fármacos , Tetracloreto de Carbono/administração & dosagem , Tetracloreto de Carbono/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Doença Hepática Induzida por Substâncias e Drogas/patologia , Hepatite Animal/induzido quimicamente , Hepatite Animal/metabolismo , Hepatite Animal/patologia , Inativação Metabólica , Metabolismo dos Lipídeos/efeitos dos fármacos , Fígado/metabolismo , Fígado/patologia , Masculino , Substâncias Protetoras/administração & dosagem , Ratos , Ratos Wistar , Silimarina/administração & dosagem , Silimarina/uso terapêutico , Tiofenos/administração & dosagem , Triglicerídeos/análiseRESUMO
Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fibrinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fibrinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability).
Assuntos
Isquemia Encefálica/tratamento farmacológico , Fenóis/uso terapêutico , Reologia , Animais , Masculino , Ratos , Ratos WistarRESUMO
Carbon tetrachloride-induced hepatitis in rats is accompanied by blood hyperviscosity syndrome development. A course intragastric administration of thiophane under these conditions prevents the increase in whole blood viscosity by normalizing the microrheological indices (deformability and aggregation of erythrocytes), which is manifested by increasing oxygen availability for tissues.
Assuntos
Viscosidade Sanguínea/efeitos dos fármacos , Intoxicação por Tetracloreto de Carbono/sangue , Tetracloreto de Carbono/toxicidade , Doença Hepática Induzida por Substâncias e Drogas/sangue , Agregação Eritrocítica/efeitos dos fármacos , Deformação Eritrocítica/efeitos dos fármacos , Tiofenos/farmacologia , Animais , Masculino , Ratos , Ratos WistarRESUMO
Neuroprotective activity of the new sterically hindered phenolic antioxidant 4-methyl-2,6-diisobornylphenol (dibornol) in rats with total transient cerebral ischemia was investigated. Dibornol decreased mortality of rats and the number of animals with severe neurological deficit; moreover, it accelerated restoration of neurological status in the survived rats. Neuroprotective activity of dibornol is based on its ability to diminish lipid peroxidation in ischemic brain, suppress cerebral tissue hypoxia and protect functional activity of endothelium. Improved oxygen delivery was a consequence of reduced hyperviscosity syndrome (enhanced deformability of erythrocytes and their decreased aggregation).
Assuntos
Isquemia Encefálica/tratamento farmacológico , Canfanos/uso terapêutico , Cresóis/uso terapêutico , Peroxidação de Lipídeos/efeitos dos fármacos , Consumo de Oxigênio/efeitos dos fármacos , Administração Oral , Animais , Isquemia Encefálica/metabolismo , Canfanos/administração & dosagem , Cresóis/administração & dosagem , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Feminino , Masculino , Fármacos Neuroprotetores/administração & dosagem , Fármacos Neuroprotetores/uso terapêutico , Consumo de Oxigênio/fisiologia , Ratos , Ratos Wistar , Resultado do TratamentoRESUMO
Along with microangiopathy, degeneration of retinal neurons is one of the basic causes of blindness in patients with diabetic retinopathy. Using the electronic microscopy and morphometric analysis, the structural changes of neurosensory cells, associative and ganglionic retinal neurons were studied in 30 albino outbred male rats with long term (2 months) streptozotocin diabetes and the effect of a new semisynthetic antioxidant belonging to a group of strictly hindered phenols (4-methyl-2,6-diisobornylphenol) on these parameters was evaluated. In diabetic rats, the destructive changes of external segments of neurosensory cells and ganglionic retinal neurons were found. The numerical density of neurosensory and ganglionic cells was reduced, while the proportion of these cells with pyknotic nuclei was increased. 4-Methyl-2,6-diisobornylphenol demonstrated neuroprotective effect by preventing destructive changes of neurosensory cells and ganglionic retinal neurons.
Assuntos
Canfanos/uso terapêutico , Cresóis/uso terapêutico , Diabetes Mellitus Experimental/complicações , Retinopatia Diabética/tratamento farmacológico , Fármacos Neuroprotetores/uso terapêutico , Neurônios Retinianos/efeitos dos fármacos , Animais , Canfanos/farmacologia , Cresóis/farmacologia , Diabetes Mellitus Experimental/patologia , Retinopatia Diabética/etiologia , Retinopatia Diabética/patologia , Masculino , Fármacos Neuroprotetores/farmacologia , Ratos , Neurônios Retinianos/patologia , EstreptozocinaRESUMO
Clinico-experimental studying the immunomorphological reactions variants in the prosthesis of anterior abdominal wall using synthetic polypropylene mesh was conducted. In 70 patients, operated on for postoperative hernia of abdominal wall using "on lay" method and the immune state were studied up by means of investigation of proinflammatory and anti-inflammatory cytokines content, in part, of tumor necrosis factor-alpha; (TNF-alpha), IL-8, IL-4. Morphological investigations were conducted in experiment on 100 the Vistar line mices, there were studied reactions of fibroblasts, macrophages, lymphocytes and leucocytes. The results of the immunological and morphological reactions on polypropylene obtained trust the necessity of differentiated approach application for the choice of the synthetic prosthesis kind, taking into account its biocompatibility, physical properties, the hernial defect size etc.
Assuntos
Parede Abdominal/patologia , Hérnia Abdominal/imunologia , Hérnia Abdominal/cirurgia , Polipropilenos , Complicações Pós-Operatórias/imunologia , Complicações Pós-Operatórias/cirurgia , Telas Cirúrgicas , Parede Abdominal/cirurgia , Adulto , Idoso , Animais , Materiais Biocompatíveis/efeitos adversos , Contagem de Células , Feminino , Fibroblastos/efeitos dos fármacos , Fibroblastos/patologia , Hérnia Abdominal/diagnóstico por imagem , Hérnia Abdominal/patologia , Humanos , Interleucina-4/imunologia , Interleucina-8/imunologia , Masculino , Camundongos , Camundongos Endogâmicos , Pessoa de Meia-Idade , Polipropilenos/efeitos adversos , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/patologia , Telas Cirúrgicas/efeitos adversos , Resultado do Tratamento , Fator de Necrose Tumoral alfa/imunologia , Ultrassonografia , Adulto JovemRESUMO
In up-to-date industrial conditions the new clinical forms of occupational pulmonary diseases occur more and more frequently in addition to the most prevalent dust pathology of the lungs. They occur in workers exposed to industrial aerosols of complex composition, including toxic substances and allergens along with fibrogenic dust. Exogenous allergic alveolitis, metalloconioses and occupational bronchitis should be distinguished among the diseases in consideration. The prophylaxis is to include measures aimed at the improvement of the working conditions, performance of preliminary and periodic medical examinations, early specialized employment and clinical examination of the patients.
Assuntos
Pneumopatias/etiologia , Doenças Profissionais/etiologia , Poluentes Ocupacionais do Ar/efeitos adversos , Bissinose/etiologia , Bissinose/prevenção & controle , Poeira/efeitos adversos , Humanos , Pneumopatias/prevenção & controle , Doenças Profissionais/prevenção & controle , Pneumoconiose/etiologia , Pneumoconiose/prevenção & controle , U.R.S.S.RESUMO
Narcotization procedure for porpoises is suggested without blocking their respiration. Premedication: atropine (1 mg per 50 kg, intravenously), Seduxen (5 mg per 100 kg, intravenously). Narcosis: sodium oxybutyrate (1 g per 50 kg, intravenously), Droperidol (12.5 mg per 100 kg, intravenously), Phentanyl (0.5 mg per 100 kg, intravenously).
Assuntos
Anestesia/métodos , Golfinhos , Respiração/efeitos dos fármacos , Animais , Droperidol , Fentanila , Medicação Pré-Anestésica , Oxibato de SódioRESUMO
For the first time it was Afghanistan where the 40th Army had faced with mass polyinfection morbidity which had a severe course and unfavourable outcome. In these conditions a new effective system of medical care to infectious patients was elaborated and applied. This system comprised a four-staged complex of medical and diagnostical measures. That made it possible to reduce the number of fatal cases by 16 times (from 0.49 to 0.03%) in 1983-1989. The total number of servicemen returned to active duty was brought up to 99.6%. The most important factors in this new system were the following: at prehospital stage--new methods in early definition of infectious patients, opportune diagnosis and emergency care; at hospital phase--new methods of triage, schemes of complex treatment for various nosological forms working principles of intensive therapy.