Detalhe da pesquisa
1.
Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO).
Bioorg Med Chem Lett
; 42: 128010, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811992
2.
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg Med Chem
; 28(22): 115723, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007547
3.
Benzothiazole-based compounds as potent endothelial lipase inhibitors.
Bioorg Med Chem Lett
; 29(20): 126673, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519373
4.
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.
Bioorg Med Chem Lett
; 29(15): 1918-1921, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176700
5.
Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].
Bioorg Med Chem Lett
; 29(17): 2525, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353296
6.
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.
Sci Transl Med
; 15(719): eadh1892, 2023 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37878674
7.
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.
BMC Pharmacol
; 12: 2, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22475049
8.
Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling.
Methods Enzymol
; 667: 685-727, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35525559
9.
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
J Med Chem
; 65(4): 3518-3538, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108011
10.
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1.
ACS Med Chem Lett
; 12(3): 443-450, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33732413
11.
Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor.
J Immunother Cancer
; 9(1)2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33408094
12.
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.
J Med Chem
; 63(4): 1660-1670, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990537
13.
Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.
Arch Biochem Biophys
; 475(1): 72-9, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455495
14.
Potent Triazolopyridine Myeloperoxidase Inhibitors.
ACS Med Chem Lett
; 9(12): 1175-1180, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613322
15.
Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
ACS Med Chem Lett
; 9(12): 1263-1268, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613337
16.
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Medchemcomm
; 8(11): 2093-2099, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108726
17.
Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
Protein Expr Purif
; 51(1): 11-21, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16854592