Detalhe da pesquisa
1.
Development of Human Immunodeficiency Virus Type 1 Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine Starting with Wild-Type or Nucleoside Reverse Transcriptase Inhibitor-Resistant Strains.
Antimicrob Agents Chemother
; 65(12): e0116721, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516245
2.
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc Natl Acad Sci U S A
; 113(33): 9274-9, 2016 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27489345
3.
Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention.
AAPS PharmSciTech
; 20(7): 286, 2019 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31410664
4.
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320718
5.
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760905
6.
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.
J Biol Chem
; 289(35): 24533-48, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24970894
7.
Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase.
Proteins
; 83(8): 1526-38, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061827
8.
Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque.
Antimicrob Agents Chemother
; 59(7): 4190-8, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25941222
9.
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
PLoS Pathog
; 9(1): e1003125, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23349632
10.
Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose-modified nucleic acids.
J Org Chem
; 80(6): 3083-91, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25723361
11.
Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission.
Pharm Res
; 32(9): 2960-72, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25794967
12.
The p66 immature precursor of HIV-1 reverse transcriptase.
Proteins
; 82(10): 2343-52, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24771554
13.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res
; 40(1): 345-59, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908397
14.
Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.
Drug Dev Ind Pharm
; 40(8): 1101-11, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23841536
15.
Biochemical mechanism of HIV-1 resistance to rilpivirine.
J Biol Chem
; 287(45): 38110-23, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22955279
16.
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
Retrovirology
; 10: 65, 2013 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23800377
17.
Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Antimicrob Agents Chemother
; 57(12): 6254-64, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100493
18.
Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.
Antimicrob Agents Chemother
; 57(9): 4554-4558, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796932
19.
The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC.
AIDS Res Ther
; 10(1): 14, 2013 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23721408
20.
HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes.
Viruses
; 15(10)2023 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37896768