Detalhe da pesquisa
1.
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
Handb Exp Pharmacol
; (203): 279-301, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21484576
2.
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
J Am Chem Soc
; 129(50): 15491-502, 2007 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18041834
3.
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
Diabetes
; 55(6): 1747-54, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16731838
4.
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
J Med Chem
; 54(1): 153-65, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126019
5.
Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics.
J Med Chem
; 53(1): 441-51, 2010 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20055427
6.
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.
J Med Chem
; 51(14): 4331-9, 2008 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18570362
7.
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Proc Natl Acad Sci U S A
; 102(22): 7970-5, 2005 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911772