Pesquisa | BVS Violência e Saúde

1.

Engineered tRNAs suppress nonsense mutations in cells and in vivo.

Albers, Suki; Allen, Elizabeth C; Bharti, Nikhil; Davyt, Marcos; Joshi, Disha; Perez-Garcia, Carlos G; Santos, Leonardo; Mukthavaram, Rajesh; Delgado-Toscano, Miguel Angel; Molina, Brandon; Kuakini, Kristen; Alayyoubi, Maher; Park, Kyoung-Joo Jenny; Acharya, Grishma; Gonzalez, Jose A; Sagi, Amit; Birket, Susan E; Tearney, Guillermo J; Rowe, Steven M; Manfredi, Candela; Hong, Jeong S; Tachikawa, Kiyoshi; Karmali, Priya; Matsuda, Daiki; Sorscher, Eric J; Chivukula, Pad; Ignatova, Zoya.

Nature ; 618(7966): 842-848, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37258671

2.

Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.

Milbank, Edward; Díaz-Trelles, Ramon; Dragano, Nathalia; Latorre, Jèssica; Mukthavaram, Rajesh; Mayneris-Perxachs, Jordi; Ortega, Francisco; Federici, Massimo; Burcelin, Remy; Karmali, Priya P; Tachikawa, Kiyoshi; Chivukula, Pad; López, Miguel; Fernández-Real, José Manuel; Moreno-Navarrete, José María.

Pharmacol Res ; 187: 106562, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36410673

3.

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.

de Alwis, Ruklanthi; Gan, Esther S; Chen, Shiwei; Leong, Yan Shan; Tan, Hwee Cheng; Zhang, Summer L; Yau, Clement; Low, Jenny G H; Kalimuddin, Shirin; Matsuda, Daiki; Allen, Elizabeth C; Hartman, Paula; Park, Kyoung-Joo Jenny; Alayyoubi, Maher; Bhaskaran, Hari; Dukanovic, Adrian; Bao, Yanjie; Clemente, Brenda; Vega, Jerel; Roberts, Scott; Gonzalez, Jose A; Sablad, Marciano; Yelin, Rodrigo; Taylor, Wendy; Tachikawa, Kiyoshi; Parker, Suezanne; Karmali, Priya; Davis, Jared; Sullivan, Brian M; Sullivan, Sean M; Hughes, Steve G; Chivukula, Pad; Ooi, Eng Eong.

Mol Ther ; 29(6): 1970-1983, 2021 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-33823303

4.

Systemic delivery of factor IX messenger RNA for protein replacement therapy.

Ramaswamy, Suvasini; Tonnu, Nina; Tachikawa, Kiyoshi; Limphong, Pattraranee; Vega, Jerel B; Karmali, Priya P; Chivukula, Pad; Verma, Inder M.

Proc Natl Acad Sci U S A ; 114(10): E1941-E1950, 2017 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-28202722

5.

Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator.

Saayman, Sheena M; Ackley, Amanda; Burdach, Jon; Clemson, Matthew; Gruenert, Dieter C; Tachikawa, Kiyoshi; Chivukula, Pad; Weinberg, Marc S; Morris, Kevin V.

Mol Ther ; 24(8): 1351-7, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27434588

6.

Quantitative proteome analysis of pluripotent cells by iTRAQ mass tagging reveals post-transcriptional regulation of proteins required for ES cell self-renewal.

O'Brien, Robert N; Shen, Zhouxin; Tachikawa, Kiyoshi; Lee, Pei Angel; Briggs, Steven P.

Mol Cell Proteomics ; 9(10): 2238-51, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-20513800

7.

Efficacy increase of lipid nanoparticles in vivo by inclusion of bis(monoacylglycerol)phosphate.

Sagi, Amit; Mukthavaram, Rajesh; Recatto, River; Hong, Hyojung; Davis, Michael; Trelles, Ramon Diaz; El-Mecharrafie, Nadja; Acharya, Grishma; Gomez, Abraham; Leu, Angel; Tachikawa, Kiyoshi; Sacchetti, Cristiano; Soontornniyomkij, Benchawanna; Rajappan, Kumar; Karmali, Priya; Chivakula, Padmanabh.

Nanomedicine (Lond) ; 17(20): 1399-1410, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-36255044

8.

Development of an mRNA replacement therapy for phenylketonuria.

Perez-Garcia, Carlos G; Diaz-Trelles, Ramon; Vega, Jerel Boyd; Bao, Yanjie; Sablad, Marciano; Limphong, Patty; Chikamatsu, Simon; Yu, Hailong; Taylor, Wendy; Karmali, Priya P; Tachikawa, Kiyoshi; Chivukula, Padmanabh.

Mol Ther Nucleic Acids ; 28: 87-98, 2022 Jun 14.

Artigo em Inglês | MEDLINE | ID: mdl-35356682

9.

Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.

Diaz-Trelles, Ramon; Lee, Sharon; Kuakini, Kristen; Park, Jenny; Dukanovic, Adrian; Gonzalez, Jose A; Dam, Thanhchau; Kim, Jae Heon; Vega, Jerel Boyd; Sablad, Marciano; Karmali, Priya P; Tachikawa, Kiyoshi; Chivukula, Padmanabh.

Mol Genet Metab Rep ; 32: 100882, 2022 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-35600090

10.

Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice.

Comas, Ferran; Díaz-Trelles, Ramon; Gavaldà-Navarro, Aleix; Milbank, Edward; Dragano, Nathalia; Morón-Ros, Samantha; Mukthavaram, Rajesh; Latorre, Jessica; Ortega, Francisco; Arnoriaga-Rodriguez, Maria; Oliveras-Cañellas, Núria; Ricart, Wifredo; Karmali, Priya P; Tachikawa, Kiyoshi; Chivukula, Pad; Villarroya, Francesc; Giralt, Marta; López, Miguel; Fernández-Real, José Manuel; Moreno-Navarrete, José María.

Biomed Pharmacother ; 151: 113156, 2022 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-35643066

11.

Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation.

Latorre, Jessica; Díaz-Trelles, Ramon; Comas, Ferran; Gavaldà-Navarro, Aleix; Milbank, Edward; Dragano, Nathalia; Morón-Ros, Samantha; Mukthavaram, Rajesh; Ortega, Francisco; Castells-Nobau, Anna; Oliveras-Cañellas, Núria; Ricart, Wifredo; Karmali, Priya P; Tachikawa, Kiyoshi; Chivukula, Pad; Villarroya, Francesc; López, Miguel; Giralt, Marta; Fernández-Real, José Manuel; Moreno-Navarrete, José María.

Mol Ther Nucleic Acids ; 29: 599-613, 2022 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-36090751

12.

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.

Wolff, Gretchen; Sakurai, Minako; Mhamane, Amit; Troullinaki, Maria; Maida, Adriano; Deligiannis, Ioannis K; Yin, Kelvin; Weber, Peter; Morgenstern, Jakob; Wieder, Annika; Kwon, Yun; Sekar, Revathi; Zeigerer, Anja; Roden, Michael; Blüher, Matthias; Volk, Nadine; Poth, Tanja; Hackert, Thilo; Wiedmann, Lena; De Angelis Rigotti, Francesca; Rodriguez-Vita, Juan; Fischer, Andreas; Mukthavaram, Rajesh; Limphong, Pattraranee; Tachikawa, Kiyoshi; Karmali, Priya; Payne, Joseph; Chivukula, Padmanabh; Ekim-Üstünel, Bilgen; Martinez-Jimenez, Celia P; Szendrödi, Julia; Nawroth, Peter; Herzig, Stephan.

Mol Metab ; 60: 101487, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35378329

13.

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.

Hirunagi, Tomoki; Sahashi, Kentaro; Tachikawa, Kiyoshi; Leu, Angel I; Nguyen, Michelle; Mukthavaram, Rajesh; Karmali, Priya P; Chivukula, Padmanabh; Tohnai, Genki; Iida, Madoka; Onodera, Kazunari; Ohyama, Manabu; Okada, Yohei; Okano, Hideyuki; Katsuno, Masahisa.

Mol Ther Nucleic Acids ; 24: 1-10, 2021 Jun 04.

Artigo em Inglês | MEDLINE | ID: mdl-33738134

14.

Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.

Rajappan, Kumar; Tanis, Steven P; Mukthavaram, Rajesh; Roberts, Scott; Nguyen, Michelle; Tachikawa, Kiyoshi; Sagi, Amit; Sablad, Marciano; Limphong, Pattraranee; Leu, Angel; Yu, Hailong; Chivukula, Padmanabh; Payne, Joseph E; Karmali, Priya.

J Med Chem ; 63(21): 12992-13012, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33119286

15.

Targeting the human genome.

Tachikawa, Kiyoshi; Briggs, Steven P.

Curr Opin Biotechnol ; 17(6): 659-65, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17085035

16.

Immune modulatory nanoparticle therapeutics for intracerebral glioma.

Yaghi, Nasser K; Wei, Jun; Hashimoto, Yuuri; Kong, Ling-Yuan; Gabrusiewicz, Konrad; Nduom, Edjah K; Ling, Xiaoyang; Huang, Neal; Zhou, Shouhao; Kerrigan, Brittany C Parker; Levine, Jonathan M; Fajt, Virginia R; Levine, Gwendolyn; Porter, Brian F; Marcusson, Eric G; Tachikawa, Kiyoshi; Chivukula, Padmanabh; Webb, David C; Payne, Joseph E; Heimberger, Amy B.

Neuro Oncol ; 19(3): 372-382, 2017 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-27765835

17.

Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth.

Yanagi, Teruki; Tachikawa, Kiyoshi; Wilkie-Grantham, Rachel; Hishiki, Asami; Nagai, Ko; Toyonaga, Ellen; Chivukula, Pad; Matsuzawa, Shu-Ichi.

Mol Ther Nucleic Acids ; 5(6): e327, 2016 Jun 28.

Artigo em Inglês | MEDLINE | ID: mdl-27351680

18.

CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities.

Sakemi, Shinichi; Bordner, Jon; DeCosta, Debra L; Dekker, Koen A; Hirai, Hideo; Inagaki, Taisuke; Kim, Yoon-Jeong; Kojima, Nakao; Sims, Jeffrey C; Sugie, Yutaka; Sugiura, Akemi; Sutcliffe, Joyce A; Tachikawa, Kiyoshi; Truesdell, Susan J; Wong, John W; Yoshikawa, Nobuji; Kojima, Yasuhiro.

J Antibiot (Tokyo) ; 55(1): 6-18, 2002 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-11918067

19.

Crystallization of the GTP-dependent transcriptional regulator CodY from Bacillus subtilis.

Blagova, Elena V; Levdikov, Vladimir M; Tachikawa, Kiyoshi; Sonenshein, Abraham L; Wilkinson, Anthony J.

Acta Crystallogr D Biol Crystallogr ; 59(Pt 1): 155-7, 2003 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-12499555

20.

Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins.

Tachikawa, Kiyoshi; Schröder, Oliver; Frey, Gerhard; Briggs, Steven P; Sera, Takashi.

Proc Natl Acad Sci U S A ; 101(42): 15225-30, 2004 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-15475575

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