Detalhe da pesquisa
1.
Role of respiratory uncoupling in drug-induced mitochondrial permeability transition.
Toxicol Appl Pharmacol
; 427: 115659, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34332991
2.
Mechanism-based integrated assay systems for the prediction of drug-induced liver injury.
Toxicol Appl Pharmacol
; 394: 114958, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198022
3.
Lipopolysaccharide administration increases the susceptibility of mitochondrial permeability transition pore opening via altering adenine nucleotide translocase conformation in the mouse liver.
J Toxicol Sci
; 48(2): 65-73, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36725022
4.
Estimating drug-induced liver injury risk by in vitro molecular initiation response and pharmacokinetic parameters for during early drug development.
Toxicol Res (Camb)
; 12(1): 86-94, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36866207
5.
New in vitro screening system to detect drug-induced liver injury using a culture plate with low drug sorption and high oxygen permeability.
Drug Metab Pharmacokinet
; 52: 100511, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531708
6.
In Vitro Assay System to Detect Drug-Induced Bile Acid-Dependent Cytotoxicity Using Hepatocytes.
Methods Mol Biol
; 2544: 119-127, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36125714
7.
A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes.
J Toxicol Sci
; 47(1): 13-18, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34987137
8.
In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.
Hepatol Commun
; 5(8): 1385-1399, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34430783
9.
Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells.
J Pharm Sci
; 110(9): 3306-3312, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097978
10.
[The trends in predicting drug-induced liver injury].
Nihon Yakurigaku Zasshi
; 155(6): 401-405, 2020.
Artigo
em Japonês
| MEDLINE | ID: mdl-33132258
11.
Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening.
Toxicol In Vitro
; 67: 104889, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32417306
12.
Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver.
Toxicol In Vitro
; 65: 104785, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991145
13.
Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury.
Toxicology
; 423: 32-41, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31102694
14.
In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.
Drug Metab Pharmacokinet
; 34(4): 264-271, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31285099
15.
Inhibition of bile canalicular network formation in rat sandwich cultured hepatocytes by drugs associated with risk of severe liver injury.
Toxicol In Vitro
; 35: 121-30, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27256767