Detalles de la búsqueda
1.
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J Am Chem Soc
; 145(36): 19691-19706, 2023 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37638886
2.
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Nucleic Acids Res
; 49(18): 10250-10264, 2021 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34508350
3.
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-ß-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.
J Am Chem Soc
; 144(32): 14517-14534, 2022 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35921401
4.
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
Nucleic Acids Res
; 48(8): 4028-4040, 2020 05 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32170309
5.
Recognition of double-stranded DNA using LNA-modified toehold Invader probes.
Org Biomol Chem
; 19(42): 9276-9290, 2021 11 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34657934
6.
Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes.
Org Biomol Chem
; 18(24): 4645-4655, 2020 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32520054
7.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res
; 46(16): 8090-8104, 2018 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30107495
8.
Head-to-head comparison of LNA, MPγPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA.
Org Biomol Chem
; 18(1): 56-65, 2019 12 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31681928
9.
Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties.
Org Biomol Chem
; 17(3): 609-621, 2019 01 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30575837
10.
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J Am Chem Soc
; 139(41): 14542-14555, 2017 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28937776
11.
Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers.
Org Biomol Chem
; 15(44): 9362-9371, 2017 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29090304
12.
C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability.
J Org Chem
; 79(11): 5062-73, 2014 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24797769
13.
Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).
J Org Chem
; 79(11): 5047-61, 2014 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24825249
14.
Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers.
Org Biomol Chem
; 12(39): 7758-73, 2014 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25144705
15.
Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides.
Chembiochem
; 14(13): 1534-1538, 2013 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-24038876
16.
Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.
J Org Chem
; 78(23): 12040-8, 2013 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24195730
17.
Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.
J Org Chem
; 78(19): 9560-70, 2013 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24032477
18.
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Nat Biotechnol
; 40(10): 1500-1508, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35654979
19.
C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing.
Chemistry
; 17(11): 3157-65, 2011 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21328492
20.
Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles.
Chem Commun (Camb)
; 51(81): 15051-4, 2015 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26314212