Detalles de la búsqueda
1.
Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake.
Drug Metab Dispos
; 52(6): 548-554, 2024 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38604729
2.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Drug Metab Dispos
; 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38697852
3.
New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry.
Anal Chem
; 95(8): 4086-4094, 2023 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36791153
4.
Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib.
Drug Metab Dispos
; 50(9): 1170-1181, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779865
5.
Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition.
Drug Metab Dispos
; 49(9): 822-832, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34183376
6.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
7.
Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947.
Drug Metab Dispos
; 48(5): 408-419, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32132091
8.
Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis.
J Pharmacol Exp Ther
; 369(3): 406-418, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940693
9.
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Drug Metab Dispos
; 47(10): 1146-1155, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31358513
10.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30622164
11.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1122-1135, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31266753
12.
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Drug Metab Dispos
; 47(10): 1156-1163, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085544
13.
Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.
Xenobiotica
; 49(12): 1423-1433, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30794022
14.
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Bioconjug Chem
; 29(2): 267-274, 2018 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29369629
15.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
16.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos
; 46(7): 943-952, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695616
17.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29487142
18.
Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
Drug Metab Dispos
; 45(5): 430-440, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28188299
19.
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Pharm Res
; 34(11): 2403-2414, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28815392
20.
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Xenobiotica
; 47(1): 50-65, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055783