Giant impacts and the origin and evolution of continents.

Earth is the only planet known to have continents, although how they formed and evolved is unclear. Here using the oxygen isotope compositions of dated magmatic zircon, we show that the Pilbara Craton in Western Australia, Earth's best-preserved Archaean (4.0-2.5 billion years ago (Ga)) continental remnant, was built in three stages. Stage 1 zircons (3.6-3.4 Ga) form two age clusters with one-third recording submantle δ18O, indicating crystallization from evolved magmas derived from hydrothermally altered basaltic crust like that in modern-day Iceland1,2. Shallow melting is consistent with giant impacts that typified the first billion years of Earth history3-5. Giant impacts provide a mechanism for fracturing the crust and establishing prolonged hydrothermal alteration by interaction with the globally extensive ocean6-8. A giant impact at around 3.6 Ga, coeval with the oldest low-δ18O zircon, would have triggered massive mantle melting to produce a thick mafic-ultramafic nucleus9,10. A second low-δ18O zircon cluster at around 3.4 Ga is contemporaneous with spherule beds that provide the oldest material evidence for giant impacts on Earth11. Stage 2 (3.4-3.0 Ga) zircons mostly have mantle-like δ18O and crystallized from parental magmas formed near the base of the evolving continental nucleus12. Stage 3 (<3.0 Ga) zircons have above-mantle δ18O, indicating efficient recycling of supracrustal rocks. That the oldest felsic rocks formed at 3.9-3.5 Ga (ref. 13), towards the end of the so-called late heavy bombardment4, is not a coincidence.

Oxygen isotopes trace the origins of Earth's earliest continental crust.

Much of the current volume of Earth's continental crust had formed by the end of the Archaean eon1 (2.5 billion years ago), through melting of hydrated basaltic rocks at depths of approximately 25-50 kilometres, forming sodic granites of the tonalite-trondhjemite-granodiorite (TTG) suite2-6. However, the geodynamic setting and processes involved are debated, with fundamental questions arising, such as how and from where the required water was added to deep-crustal TTG source regions7,8. In addition, there have been no reports of voluminous, homogeneous, basaltic sequences in preserved Archaean crust that are enriched enough in incompatible trace elements to be viable TTG sources5,9. Here we use variations in the oxygen isotope composition of zircon, coupled with whole-rock geochemistry, to identify two distinct groups of TTG. Strongly sodic TTGs represent the most-primitive magmas and contain zircon with oxygen isotope compositions that reflect source rocks that had been hydrated by primordial mantle-derived water. These primitive TTGs do not require a source highly enriched in incompatible trace elements, as 'average' TTG does. By contrast, less sodic 'evolved' TTGs require a source that is enriched in both water derived from the hydrosphere and also incompatible trace elements, which are linked to the introduction of hydrated magmas (sanukitoids) formed by melting of metasomatized mantle lithosphere. By concentrating on data from the Palaeoarchaean crust of the Pilbara Craton, we can discount a subduction setting6,10-13, and instead propose that hydrated and enriched near-surface basaltic rocks were introduced into the mantle through density-driven convective overturn of the crust. These results remove many of the paradoxical impediments to understanding early continental crust formation. Our work suggests that sufficient primordial water was already present in Earth's early mafic crust to produce the primitive nuclei of the continents, with additional hydrated sources created through dynamic processes that are unique to the early Earth.

Metamorphism and the evolution of plate tectonics.

Earth's mantle convection, which facilitates planetary heat loss, is manifested at the surface as present-day plate tectonics1. When plate tectonics emerged and how it has evolved through time are two of the most fundamental and challenging questions in Earth science1-4. Metamorphic rocks-rocks that have experienced solid-state mineral transformations due to changes in pressure (P) and temperature (T)-record periods of burial, heating, exhumation and cooling that reflect the tectonic environments in which they formed5,6. Changes in the global distribution of metamorphic (P, T) conditions in the continental crust through time might therefore reflect the secular evolution of Earth's tectonic processes. On modern Earth, convergent plate margins are characterized by metamorphic rocks that show a bimodal distribution of apparent thermal gradients (temperature change with depth; parameterized here as metamorphic T/P) in the form of paired metamorphic belts5, which is attributed to metamorphism near (low T/P) and away from (high T/P) subduction zones5,6. Here we show that Earth's modern plate tectonic regime has developed gradually with secular cooling of the mantle since the Neoarchaean era, 2.5 billion years ago. We evaluate the emergence of bimodal metamorphism (as a proxy for secular change in plate tectonics) using a statistical evaluation of the distributions of metamorphic T/P through time. We find that the distribution of metamorphic T/P has gradually become wider and more distinctly bimodal from the Neoarchaean era to the present day, and the average metamorphic T/P has decreased since the Palaeoproterozoic era. Our results contrast with studies that inferred an abrupt transition in tectonic style in the Neoproterozoic era (about 0.7 billion years ago1,7,8) or that suggested that modern plate tectonics has operated since the Palaeoproterozoic era (about two billion years ago9-12) at the latest.

Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD).

BACKGROUND: Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for clinically important outcomes in persons with CKD referred to secondary care. METHODS: Eligible participants with CKD stages G3-4 or stages G1-2 plus albuminuria >30 mg/mmol were enrolled from 16 nephrology centres in England, Scotland and Wales from 2017 to 2019. Baseline assessment included demographic data, routine laboratory data and research samples. Clinical outcomes are being collected over 15 years by the UK Renal Registry using established data linkage. Baseline data are presented with subgroup analysis by age, sex and estimated glomerular filtration rate (eGFR). RESULTS: A total of 2996 participants was enrolled. Median (interquartile range) age was 66 (54-74) years, eGFR 33.8 (24.0-46.6) mL/min/1.73 m2 and urine albumin to creatinine ratio 209 (33-926) mg/g; 58.5% were male. Of these participants, 1883 (69.1%) were in high-risk CKD categories. Primary renal diagnosis was CKD of unknown cause in 32.3%, glomerular disease in 23.4% and diabetic kidney disease in 11.5%. Older participants and those with lower eGFR had higher systolic blood pressure and were less likely to be treated with renin-angiotensin system inhibitors (RASi) but were more likely to receive a statin. Female participants were less likely to receive a RASi or statin. CONCLUSIONS: NURTuRE-CKD is a prospective cohort of persons who are at relatively high risk of adverse outcomes. Long-term follow-up and a large biorepository create opportunities for research to improve risk prediction and to investigate underlying mechanisms to inform new treatment development.

Earth's first stable continents did not form by subduction.

The geodynamic environment in which Earth's first continents formed and were stabilized remains controversial. Most exposed continental crust that can be dated back to the Archaean eon (4 billion to 2.5 billion years ago) comprises tonalite-trondhjemite-granodiorite rocks (TTGs) that were formed through partial melting of hydrated low-magnesium basaltic rocks; notably, these TTGs have 'arc-like' signatures of trace elements and thus resemble the continental crust produced in modern subduction settings. In the East Pilbara Terrane, Western Australia, low-magnesium basalts of the Coucal Formation at the base of the Pilbara Supergroup have trace-element compositions that are consistent with these being source rocks for TTGs. These basalts may be the remnants of a thick (more than 35 kilometres thick), ancient (more than 3.5 billion years old) basaltic crust that is predicted to have existed if Archaean mantle temperatures were much hotter than today's. Here, using phase equilibria modelling of the Coucal basalts, we confirm their suitability as TTG 'parents', and suggest that TTGs were produced by around 20 per cent to 30 per cent melting of the Coucal basalts along high geothermal gradients (of more than 700 degrees Celsius per gigapascal). We also analyse the trace-element composition of the Coucal basalts, and propose that these rocks were themselves derived from an earlier generation of high-magnesium basaltic rocks, suggesting that the arc-like signature in Archaean TTGs was inherited from an ancestral source lineage. This protracted, multistage process for the production and stabilization of the first continents-coupled with the high geothermal gradients-is incompatible with modern-style plate tectonics, and favours instead the formation of TTGs near the base of thick, plateau-like basaltic crust. Thus subduction was not required to produce TTGs in the early Archaean eon.

Corrigendum: Earth's first stable continents did not form by subduction.

This corrects the article DOI: 10.1038/nature21383.

The internal structure and geodynamics of Mars inferred from a 4.2-Gyr zircon record.

Combining U-Pb ages with Lu-Hf data in zircon provides insights into the magmatic history of rocky planets. The Northwest Africa (NWA) 7034/7533 meteorites are samples of the southern highlands of Mars containing zircon with ages as old as 4476.3 ± 0.9 Ma, interpreted to reflect reworking of the primordial Martian crust by impacts. We extracted a statistically significant zircon population (n = 57) from NWA 7533 that defines a temporal record spanning 4.2 Gyr. Ancient zircons record ages from 4485.5 ± 2.2 Ma to 4331.0 ± 1.4 Ma, defining a bimodal distribution with groupings at 4474 ± 10 Ma and 4442 ± 17 Ma. We interpret these to represent intense bombardment episodes at the planet's surface, possibly triggered by the early migration of gas giant planets. The unradiogenic initial Hf-isotope composition of these zircons establishes that Mars's igneous activity prior to ∼4.3 Ga was limited to impact-related reworking of a chemically enriched, primordial crust. A group of younger detrital zircons record ages from 1548.0 ± 8.8 Ma to 299.5 ± 0.6 Ma. The only plausible sources for these grains are the temporally associated Elysium and Tharsis volcanic provinces that are the expressions of deep-seated mantle plumes. The chondritic-like Hf-isotope compositions of these zircons require the existence of a primitive and convecting mantle reservoir, indicating that Mars has been in a stagnant-lid tectonic regime for most of its history. Our results imply that zircon is ubiquitous on the Martian surface, providing a faithful record of the planet's magmatic history.

Civilian public sector employment as a long-run outcome of military conscription.

Since at least T. H. Marshall, scholars have recognized military service as a form of sacrifice that warrants compensation from the state. War-widow pensions, expansion of the franchise, and subsidized higher education are all examples of rights and benefits "bestowed" in return for wartime mobilization. Similarly, in the United States, governments have hired veterans preferentially for civilian public jobs as recompense for active military service. Although oft overlooked, those policies seem influential: the percentage of job holders identifying as veterans in the civilian US executive branch exceeds the proportion in the wider population by several multiples. This century-old pattern suggests another way that wartime mobilization has influenced the state. Yet, efforts to understand it have struggled to rule out the possibility that those who serve in the armed forces are predisposed to work for the state in both military and civilian capacities. Here, we rule out this possibility by examining whether birthdates randomly called for induction in the Vietnam-Era Selective Service Lotteries (VSSL) appear disproportionately in the population of nonsensitive personnel records of the civilian US executive branch. We find that birthdates called for induction appear with unusually high frequency among employees who were draft eligible and at risk for induction but not among other employees. This finding suggests a treatment effect from military service, thus dovetailing with the hypothesis that wartime mobilization has substantially and continually influenced who works in the contemporary administrative state.

Post-remediation geophysical assessment: Investigating long-term electrical geophysical signatures resulting from bioremediation at a chlorinated solvent contaminated site.

There is a growing need to assess long-term impacts of active remediation strategies on treated aquifers. A variety of biogeochemical alterations can result from interactions of the amendment with the aquifer, conceivably leading to a geophysical signal associated with the long-term alteration of an aquifer. This concept of post-remediation geophysical assessment was investigated in a shallow, chlorinated solvent-contaminated aquifer six to eight years after amendment delivery. Surface resistivity imaging and cross-borehole resistivity and induced polarization (IP) imaging were performed on a transect that spanned treated and untreated zones of the aquifer. Established relationships between IP parameters and surface electrical conductivity were used to predict vertical profiles of electrolytic conductivity and surface conductivity from the inverted cross-borehole images. Aqueous geochemistry data, along with natural gamma and magnetic susceptibility logs, were used to constrain the interpretation. The electrical conductivity structure determined from surface and borehole imaging was foremost controlled by the electrolytic conductivity of the interconnected pore space, being linearly related to fluid specific conductance. The electrolytic conductivity (and thus the conductivity images alone) did not discriminate between treated and untreated zones of the aquifer. In contrast, inverted phase angles and surface conductivities did discriminate between treated and untreated zones of the aquifer, with the treated zone being up to an order of magnitude more polarizable in places. Supporting aqueous chemistry and borehole logging datasets indicate that this geophysical signal from the long-term impact of the remediation on the aquifer is most likely associated with the formation of polarizable, dispersed iron sulfide minerals.

Optical design and intensity interferometry simulations in support of the Kilometer Space Telescope.

Very large telescopes will be needed for the future of space science, space laser-com, and other interstellar or interplanetary applications. However, as telescopes' diameters increase, their weight and cost increase dramatically. An approximation for ground-based observatories is that their cost increases to the power of 2.7 of its diameter [SAO, Special Report #385 (1979), p. 9]. Large space-based telescopes become limited by the rocket size and power. Multiple telescopes are also needed for very long baseline interferometry (VLBI), which further increases cost. A solution to overcome these issues is the use of inflatable telescopes. A thin mirror material clearly has much lower mass; however, controlling its surface error or wavefront can be a challenge. Intensity interferometry is an imaging method that has a much looser sensitivity to wavefront error (WFE), and thus is an ideal match for very large inflatable telescopes. A spherical inflatable mirror is the most practical; however, it suffers from spherical aberration. This paper presents new optical designs and simulations for intensity interferometry in support of large inflatable spherical telescopes. The optical system design includes a novel five-mirror off-axis, free-form, spherical aberration corrector. The system design shown is a 10 m diameter f/1 spherical primary mirror with 1.2 arcmin (0.02°) field of view (FOV). MATLAB simulations of intensity interferometry combine signal with noise and WFE. Visibility-based VLBI image simulations are shown based on various telescope arrays. Simulations show that with a 1 GHz detector, a 1 cm RMS WFE is tolerable. So the challenge of the optical design is then more about gathering and concentrating the light down to a reasonable size detector. Further simulations of signal combined with noise indicate that the signal rate must be about 100 times higher than the noise rate for an adequate intensity interferometry measurement. Visibility-based image simulations reveal that many telescopes (5-20 per axis) are needed in a 2D array out to the first visibility minimum to adequately resolve unknown features of a distant object.

Insights into the heparan sulphate-dependent externalisation of transglutaminase-2 (TG2) in glucose-stimulated proximal-like tubular epithelial cells.

The extracellular matrix crosslinking enzyme transglutaminase 2 (TG2) is highly implicated in tissue fibrosis that precedes end-stage kidney failure. TG2 is unconventionally secreted through extracellular vesicles in a way that depends on the heparan sulphate (HS) proteoglycan syndecan-4 (Sdc4), the deletion of which reduces experimental kidney fibrosis as a result of lower extracellular TG2 in the tubule-interstitium. Here we establish a model of TG2 externalisation in NRK-52E tubular epithelial cells subjected to glucose stress. HS-binding TG2 mutants had reduced extracellular TG2 in transfected NRK-52E, suggesting that TG2-externalisation depends on an intact TG2 heparin binding site. Inhibition of N-ethylmaleimide sensitive factor (NSF) vesicle-fusing ATPase, which was identified in the recently elucidated TG2 kidney membrane-interactome, led to significantly lower TG2-externalisation, thus validating the involvement of membrane fusion in TG2 secretion. As cyclin-G-associated kinase (GAK) had emerged as a further TG2-partner in the fibrotic kidney, we investigated whether glucose-induced TG2-externalisation was accompanied by TG2 phosphorylation in consensus sequences of cyclin-dependent kinase (CDK). Glucose stress led to intense TG2 phosphorylation in serine/threonine CDK-target. TG2 phosphorylation by tyrosine kinases was also increased by glucose. Although the precise role of glucose-induced TG2 phosphorylation is unknown, these novel data suggest that phosphorylation may be involved in TG2 membrane-trafficking.

Image distortion, pupil coma, and relative illumination.

Relative illumination is affected by image distortion, pupil coma, and pupil magnification. Image and pupil aberrations have a known relationship that also can be written in terms of pupil magnification. Pupil coma is the stretching or compression of the pupil along the field axis, which directly affects relative illumination. Front-stopped designs have pupil aberrations on the exit pupil while rear-stopped systems have pupil aberrations on the entrance pupil. Of the primary pupil aberrations, pupil coma can have the largest effect on the relative illumination in optical designs with significant image distortion (ex: fisheye lens). The Lagrange invariant holds for systems with image distortion using a paraxial approximation of pupil coma. Relative illumination can be written in terms of % distortion, pupil magnification, and object-space field angle.

Zernike monomials in wide field of view optical designs.

Zernike polynomials are universal in optical modeling and testing of wavefronts; however, their polynomial behavior can cause a misinterpretation of individual aberrations. Wavefront profiles described by Zernike polynomials contain multiple terms with different orders of pupil radius (ρ). Zernike polynomials are a sum of high and low orders of ρ to minimize the RMS wavefront error and to preserve orthogonality. Since the low-order polynomials are still contained in the net Zernike sum, there is redundancy in individual monomials. Monomial aberrations, also known as Seidel or primary aberrations, are useful in studying an optical design's complexity, alignment, and field behavior. Zernike polynomial aberrations reported by optical design software are not indicative of individual (monomial) aberrations in wide field of view designs since the low-order polynomials are contaminated by higher order terms. An aberration node is the field location where an individual (monomial) aberration is zero. In this paper, a matrix method is shown to calculate the individual monomial aberrations given the set of Zernike polynomials. Monomial aberrations plotted as a function of field angle (H) indicate the field order (Hn) and the location of true aberration nodes. Contrarily, Zernike polynomial versus field (ZvF) plots can indicate false aberration nodes, due to the polynomial mixing of high- and low-order terms. Accurate knowledge of the monomial aberration nodes, converted from Zernike polynomials, provides the link between a ray-trace model or lab wavefront measurement and nodal aberration theory (NAT). This method is applied to two different optical designs: (1) 120° circular FOV fish-eye lens and (2) 120∘×4∘ rectangular FOV, off-axis, freeform four-mirror design.

Optical design using image distortion for orthorectification.

Imaging the curved Earth from above typically results in a distorted image with reduced spatial resolution near the edge of the field. The effect is proportional to the field of view (FOV) and altitude. It is similar to the negative (barrel) distortion common in fish-eye lenses, but is due here to the convex object and not the optical system. Although image processing methods exist to partially correct for negative distortion, the reduced spatial resolution near the edge of the field is unrecoverable. Instead this can be corrected for optically by inducing the right amount of positive distortion into the optical design. The amount of positive distortion required to counter the negative distortion from the curved Earth is calculated as a function of FOV and altitude. An optical system with positive distortion is more challenging to design than with negative distortion as this increases the FOV in image space and requires a larger focal plane array. An off-axis, all-reflective design with f/2.5, 2.5 in. effective focal length, 70∘×4∘ FOV, +13% distortion is shown that could be used as a push-broom satellite sensor in a polar orbit with constant spatial resolution.

Moral externalization is an implausible mechanism for cooperation, let alone "hypercooperation".

To facilitate cooperation, moral externalization requires truthful and meticulous information about others' moral commitments (Stanford target article, sect. 6). By definition, this information does not exist in the low-information environments where humans display their "hypercooperativeness." Furthermore, collecting that information - if possible - entails costs that other mechanisms for correlated interaction avoid. Hence, moral externalization is an unlikely mechanism for cooperation, let alone "hypercooperation."

Defining recurrence of nonmelanoma skin cancer after Mohs micrographic surgery: Report of the American College of Mohs Surgery Registry and Outcomes Committee.

BACKGROUND: Standardized definitions and methods of surveillance for local recurrence of nonmelanoma skin cancer are critical in determining cure rates attributed to treatment modalities. OBJECTIVE: We sought to offer a standard definition of local recurrence after surgical treatment of nonmelanoma skin cancer and to propose an acceptable surveillance period and tracking methods. METHODS: A literature search was performed for background definitions of local recurrence and tracking methods. The American College of Mohs Surgery (ACMS) Registry and Outcomes Committee then conducted a modified Delphi process to arrive at consensus definitions. RESULTS: We define local recurrence as a tumor with comparable histology, with contiguity to the surgical scar after treatment, and that arises within the area of the previously treated tumor. LIMITATIONS: This project reports the results of a modified Delphi method process involving members of the ACMS. The model described may not be useful for nonexcision type treatments such as topical chemotherapy, electrodessication and curettage, or radiation treatment. CONCLUSIONS: Previous definitions of recurrence and surveillance methods after surgical treatment of nonmelanoma skin cancer are variable and nonstandard. We describe consensus standards for defining and tracking recurrence that should allow for consistent scientific evaluation and development of performance data in skin cancer outcomes registries.

Inhibition of Thrombin-Activated Fibrinolysis Inhibitor Increases Survival in Experimental Kidney Fibrosis.

Uncontrolled diabetes, inflammation, and hypertension are key contributors to progressive renal fibrosis and subsequent loss of renal function. Reduced fibrinolysis appears to be a feature of ESRD, but its contribution to the fibrotic program has not been extensively studied. Here, we show that in patients with CKD, the activity levels of serum thrombin-activated fibrinolysis inhibitor and plasmin strongly correlated with the degree of renal function impairment. We made similar observations in rats after subtotal nephrectomy and tested whether pharmacologic inhibition of thrombin-activated fibrinolysis inhibitor with UK-396082 could reduce renal fibrosis and improve renal function. Compared with untreated animals, UK-396082-treated animals had reduced glomerular and tubulointerstitial fibrosis after subtotal nephrectomy. Renal function, as measured by an increase in creatinine clearance, was maintained and the rate of increase in proteinuria was reduced in UK-396082-treated animals. Furthermore, cumulative survival improved from 16% to 80% with inhibition of thrombin-activated fibrinolysis inhibitor. Taken together, these data support the importance of the fibrinolytic axis in regulating renal fibrosis and point to a potentially important therapeutic role for suppression of thrombin-activated fibrinolysis inhibitor activity.

Sexual identity development: relationship with lifetime suicidal ideation in sexual minority women.

AIMS AND OBJECTIVES: This study draws on a life course perspective to evaluate in a sample of sexual minority women: (1) the relationship between age at reaching sexual identity milestones and risk of suicidal ideation, (2) developmental stages or stages of sexual identity development that represent greatest risk and (3) the relationship between age of reaching milestones and parental support. BACKGROUND: Research shows higher rates of suicidal ideation among sexual minority women than heterosexual women. Evidence suggests this is partly accounted for by risk factors including sexual identity development and parental support. However, it remains unclear whether there are stages of particularly high risk. DESIGN: This is a cross-sectional study. Data come from a prospective study of sexual minority women that used convenience and respondent-driven sampling methods. METHODS: Using logistic regression, we examined associations among age at sexual identity developmental milestones, parental support and suicidal ideation in a large (N = 820), ethnically diverse sample of sexual minority women. RESULTS: Compared with women who first wondered about their sexual identity in adulthood, those who first wondered in early, middle or late adolescence had greater odds of lifetime suicidal ideation. Younger age at subsequent milestones (first decided or first disclosed) was not associated with heightened risk of suicidal ideation. Parental support was independently associated with suicidal ideation. CONCLUSIONS: Findings suggest that where one is in the process of identifying as a sexual minority may be more important than age in understanding risk of suicidal ideation in this population. As individuals come to accept and integrate their sexual minority identity risks associated with younger age diminish. RELEVANCE TO CLINICAL PRACTICE: Nurses and other healthcare providers who work with youth should routinely ask about sexual orientation and suicidal ideation and be aware that youth in the earliest stages of coming out as sexual minority may be at particularly high risk of suicide.