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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 57(1): 22-28, 2023 Jan 06.
Artículo en Zh | MEDLINE | ID: mdl-36655253

RESUMEN

Objective: To analyze the status quo of the knowledge and related factors of cancer prevention and treatment among residents in Liaoning Province in 2021. Methods: From August to November 2021, through network sampling method, 17 474 permanent residents aged 15-69 years in Liaoning Province were surveyed. The WeChat public account was used to collect information such as demographic characteristics and core knowledge of cancer prevention and treatment. The Chi-square test was used to compare the difference of the level of the cancer prevention and treatment knowledge among different groups. The multivariate logistic regression model was used to analyze the related factors. Results: Among the 17 474 subjects, 43.1% (7 528) were male and 58.7% (10 262) were urban residents. The overall awareness rate was 72.3%, and the awareness rate of cancer cognition, prevention, early diagnosis and treatment, cancer management and rehabilitation were 71.4%, 67.6%, 72.7%, 83.4% and 63.5%, respectively. The multivariate logistic regression model showed that the residents who were man (OR: 0.850, 95%CI: 0.781-0.925), in rural areas (OR: 0.753, 95%CI: 0.694-0.817), 55-59 years old (OR: 0.851, 95%CI: 0.751-0.963), quitters (OR: 0.721, 95%CI: 0.640-0.813) and smoker (OR: 0.724, 95%CI: 0.654-0.801) had lower awareness rates, while the residents who were 35-54 years old (OR: 1.312, 95%CI: 1.202-1.432), with an educational level of junior high school/senior high school/college degree or above (OR: 1.834-5.130, 95%CI: 1.575-6.047), technical personnel (OR: 1.592, 95%CI: 1.367-1.854), civil servant/institution staff (OR: 1.282, 95%CI: 1.094-1.503), enterprise/business/service staff (OR: 1.218, 95%CI: 1.071-1.385), retired (OR: 1.324, 95%CI: 1.114-1.573) and with family history of cancer (OR: 1.369, 95%CI: 1.266-1.481) had higher awareness rates. Conclusion: The level of the awareness of core knowledge of cancer prevention and treatment among residents in Liaoning Province has met the requirements of the Healthy China Action. Region, gender, education level, age, family history of cancer and smoking are relevant factors.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Neoplasias , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , China , Neoplasias/prevención & control , Encuestas y Cuestionarios , Adolescente , Adulto Joven , Anciano
2.
Opt Express ; 28(7): 9875-9884, 2020 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-32225586

RESUMEN

The atom-light hybrid interferometer recently attracted much attention in the research of precision metrology for its combination of light and atomic spin wave. With the AC Stark effect and proper design, it can be applied in the scheme of quantum non-demolition (QND) measurement of photon numbers. In this work, we apply the QND criteria to the scheme and theoretically derive its explicit formulas with various losses of the atomic-light hybrid interferometer. With the formulas and actual experiment parameters, we estimate and compare the performance of the vapor-atom-based and cold-atom-based hybrid interferometer in the QND measurement, analyze the influences of different kinds of losses, and provide optimized working parameter ranges of the interferometer.

3.
Zhonghua Wai Ke Za Zhi ; 58(7): 530-538, 2020 Jul 01.
Artículo en Zh | MEDLINE | ID: mdl-32610424

RESUMEN

To compare short-term and long-term efficacy after laparoscopic left hepatectomy(LLR) to open left hepatectomy(OLH) for primary left-sided hepatolithiasis. Methods: Clinical data of 187 patients with left-sided hepatolithiasis and underwent laparoscopically or open left-sided hepatectomy from October 2014 to October 2019 at the Second Affiliated Hospital of Anhui Medical University were retrospectively analyzed in this propensity score matching (PSM) study and were matched in terms of age, sex, body mass index, liver function, ASA score, comorbidities, history of biliary surgery, and smoking history on the ratio of 1∶1.There were 47 cases in each group and the mean age were (54.7±12.3)years old(range:34 to 75 years old) and (53.2±12.6) years old (range: 34 to 75 years old) in open and laparoscopically group respectively. The data of operation time, intraoperative blood loss, postoperative hospital-stay, complication rate, biliary fistula rate, stone clearance rate, and stone recurrence rate were compared. The quantitative data were compared using t-test or rank-sum test. Count data were analyzed with χ(2) test or Fisher test. Results: No significant difference was observed in the clinical characteristics of included 94 patients in this study(all P>0.05).The length of the postoperative hospital-stay after OLH was significantly higher than that in the LLH group((10.8±3.1) days vs.(8.5±2.2)days, t=4.085, P=0.000). LLR significantly decreased the incidence of postoperative biliary fistula compared with the OLH (6.3% vs.21.2%, χ(2)=4.374, P=0.036) and the rates of postoperative complications in the OLH group was significantly higher than that in the LLH group (48.9% vs.27.6%, χ(2)=4.502, P=0.034). Moreover, the stone recurrence rates in the LLH group was significantly lower than that after OLR (4.2% vs. 17.0%, χ(2)=4.029, P=0.045). OLH (95% CI: 1.55 to 10.75, P=0.004) and postoperative complications (95% CI: 1.29 to 9.52, P=0.013) were independent risk factors for prolonged hospital stay. OLH (95% CI: 1.428 to 44.080, P=0.018) and residual stones (95% CI: 1.580 to 62.379, P=0.014) were independent risk factors for the occurrence of postoperative biliary fistula. Biliary fistula (95% CI: 1.078 to 24.517, P=0.040) was an independent risk factor for the recurrence of stones. Conclusion: Compared with OLH, LLH is safe and effective for the treatment of the primary left-sided hepatolithiasis with the clinical benefits of shorter hospital stay, fewer morbidity and biliary fistula occurrence, and lower stone recurrence rates.


Asunto(s)
Hepatectomía/métodos , Litiasis/cirugía , Hepatopatías/cirugía , Adulto , Anciano , Estudios de Seguimiento , Hepatectomía/efectos adversos , Humanos , Laparoscopía , Persona de Mediana Edad , Puntaje de Propensión , Estudios Retrospectivos , Resultado del Tratamiento
4.
Eur Radiol ; 25(5): 1257-66, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25577516

RESUMEN

OBJECTIVE: To compare the clinicoradiologic features of tumours with echinoderm anaplastic lymphoma kinase (ALK) rearrangements, epidermal growth factor receptor (EGFR) mutations, or wild type (WT) for both genes in a cohort of patients with lung adenocarcinoma to identify useful characteristics of different gene statuses. METHODS: In 346 lung adenocarcinoma patients, ALK rearrangements were confirmed with fluorescence in situ hybridisation, and EGFR mutations were determined by pyrosequencing assay. Patients were divided into three groups: ALK rearrangement (ALK+ group, n = 48), EGFR mutation (EGFR+ group, n = 166), and WT for both genes (WT group, n = 132). Chest computed tomography (CT) examinations were performed in all patients. The percentages of ground-glass opacity volume (pGGO) and tumour shadow disappearance rate (TDR) were measured using semi-automated nodule assessment software. RESULTS: The pGGO was significantly lower in the ALK+ group (25.1 % ± 24.3) than in the EGFR+ group (37.2 % ± 25.7, p < 0.001) and the WT group (36.1 % ± 24.6, p = 0.001). The TDR in the ALK+ group (17.3 % ± 25.1) was significantly lower than in the EGFR+ group (26.8 % ± 24.9, p = 0.002) and the WT group (25.7 % ± 24.6, p = 0.003). CONCLUSIONS: Solid pattern with lower incidence of lobulated border, finely spiculated margins, pleural retraction, and bubble-like lucency on CT imaging are the main characteristics of ALK rearrangement tumours. KEY POINTS: • EGFR/ALK testing is recommended for lung adenocarcinoma patients for EGFR/ALK-targeted TKI therapy. • EGFR /ALK testing is restricted by limited tissue samples and cost pressures. • Lower pGGO and TDR are the main clinicoradiological characteristics of ALK+ tumours. • pGGO and TDR are predictive factors for selecting patients for ALK/EGFR testing.


Asunto(s)
Adenocarcinoma/diagnóstico por imagen , Adenocarcinoma/genética , Receptores ErbB/genética , Reordenamiento Génico/genética , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/genética , Mutación/genética , Proteínas Tirosina Quinasas Receptoras/genética , Adenocarcinoma del Pulmón , Adulto , Anciano , Anciano de 80 o más Años , Quinasa de Linfoma Anaplásico , Femenino , Humanos , Hibridación Fluorescente in Situ , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos X/métodos , Adulto Joven
5.
Cell Death Dis ; 10(5): 371, 2019 May 08.
Artículo en Inglés | MEDLINE | ID: mdl-31068574

RESUMEN

This article has been retracted at the request of the authors. After publication, the authors found that in Figure 2B-a the first two images in the third row partly overlapped and that there is also overlap between the fourth and fifth image in the second row. The two images were taken from two adjacent wells, treated by ZA 0.3uM-CM or ZA 0.75uM-CM, with or without PL 1.25uM. This overlap may have been caused by mishandling in the imaging process when the authors made microscope observations and so the findings are no longer reliable. All authors agree to this retraction.

6.
Cell Death Dis ; 7: e2094, 2016 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-26866274

RESUMEN

The treatment of breast cancer-induced osteolysis remains a challenge in clinical settings. Here, we explored the effect and mechanism of combined treatment with zoledronic acid (ZA) and plumbagin (PL), a widely investigated component derived from Plumbago zeylanica, against breast cancer-induced osteoclastogenesis. We found that the combined treatment with PL and ZA suppressed cell viability of precursor osteoclasts and synergistically inhibited MDA-MB-231-induced osteoclast formation (combination index=0.28) with the abrogation of recombinant mouse receptor activator of nuclear factor-κB ligand (RANKL)-induced activation of NF-κB/MAPK (nuclear factor-κB/mitogen-activated protein kinase) pathways. Molecular docking suggested a putative binding area within c-Jun N-terminal kinase/extracellular signal-regulated kinase (JNK/Erk) protease active sites through the structural mimicking of adenosine phosphate (ANP) by the spatial combination of PL with ZA. A homogeneous time-resolved fluorescence assay further illustrated the direct competitiveness of the dual drugs against ANP docking to phosphorylated JNK/Erk, contributing to the inhibited downstream expression of c-Jun/c-Fos/NFATc-1 (nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1). Then, in vivo testing demonstrated that the combined administration of PL and ZA attenuated breast cancer growth in the bone microenvironment. Additionally, these molecules prevented the destruction of proximal tibia, with significant reduction of tartrate-resistant acid phosphatase (TRAcP)-positive osteoclast cells and potentiation of apoptotic cancer cells, to a greater extent when combined than when the drugs were applied independently. Altogether, the combination treatment with PL and ZA could significantly and synergistically suppress osteoclastogenesis and inhibit tumorigenesis both in vitro and in vivo by simulating the spatial structure of ANP to inhibit competitively phosphorylation of c-Jun N-terminal kinase/extracellular signal-regulated kinase (JNK/Erk).


Asunto(s)
Nucleótidos de Adenina/metabolismo , Protocolos de Quimioterapia Combinada Antineoplásica/farmacología , Neoplasias de la Mama/tratamiento farmacológico , Difosfonatos/farmacología , Imidazoles/farmacología , Naftoquinonas/farmacología , Osteólisis/tratamiento farmacológico , Animales , Neoplasias de la Mama/metabolismo , Neoplasias de la Mama/patología , Línea Celular Tumoral , Difosfonatos/administración & dosificación , Modelos Animales de Enfermedad , Sinergismo Farmacológico , Femenino , Humanos , Imidazoles/administración & dosificación , Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo , Sistema de Señalización de MAP Quinasas/efectos de los fármacos , Ratones , Ratones Endogámicos BALB C , Ratones Desnudos , Naftoquinonas/administración & dosificación , Osteoclastos/efectos de los fármacos , Osteoclastos/metabolismo , Osteoclastos/patología , Osteólisis/patología , Fosforilación , Distribución Aleatoria , Transducción de Señal , Ácido Zoledrónico
7.
J Mol Neurosci ; 15(2): 85-97, 2000 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11220788

RESUMEN

Stroke is a major cause of long-term disability, the severity of which is directly related to the numbers of neurons that succumb to the ischemic insult. The signaling cascades activated by cerebral ischemia that may either promote or protect against neuronal death are not well understood. One injury-responsive signaling pathway that has recently been characterized in studies of non-neural cells involves cleavage of membrane sphingomyelin by acidic and/or neutral sphingomyelinase (ASMase) resulting in generation of the second messenger ceramide. We now report that transient focal cerebral ischemia induces large increases in ASMase activity, ceramide levels, and production of inflammatory cytokines in wild-type mice, but not in mice lacking ASMase. The extent of brain tissue damage is decreased and behavioral outcome improved in mice lacking ASMase. Neurons lacking ASMase exhibit decreased vulnerability to excitotoxicity and hypoxia, which is associated with decreased levels of intracellular calcium and oxyradicals. Treatment of mice with a drug that inhibits ASMase activity and ceramide production reduces ischemic neuronal injury and improves behavioral outcome, suggesting that drugs that inhibit this signaling pathway may prove beneficial in stroke patients.


Asunto(s)
Ceramidas/metabolismo , Corteza Cerebral/enzimología , Citocinas/biosíntesis , Ataque Isquémico Transitorio/fisiopatología , Neuronas/fisiología , Esfingomielina Fosfodiesterasa/metabolismo , Animales , Apoptosis , Encéfalo/patología , Hidrocarburos Aromáticos con Puentes/farmacología , Calcio/metabolismo , Supervivencia Celular , Corteza Cerebral/patología , Infarto Cerebral/patología , Infarto Cerebral/fisiopatología , Modelos Animales de Enfermedad , Activación Enzimática/efectos de los fármacos , Homeostasis , Ataque Isquémico Transitorio/enzimología , Ataque Isquémico Transitorio/genética , Cinética , Ratones , Ratones Noqueados , Neuronas/citología , Neuronas/patología , Norbornanos , Inhibidores de Fosfodiesterasa/farmacología , Sistemas de Mensajero Secundario , Esfingomielina Fosfodiesterasa/deficiencia , Esfingomielina Fosfodiesterasa/genética , Tiocarbamatos , Tionas/farmacología
8.
J Ethnopharmacol ; 83(1-2): 161-5, 2002 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-12413724

RESUMEN

Curcuma longa (turmeric) is a well-known indigenous herbal medicine. The aqueous extracts, when administered orally to the mice from 140 to 560 mg/kg for 14 days, were able to elicit dose-dependent relation of immobility reduction in the tail suspension test and the forced swimming test in mice. The effects of the extracts at the dose of 560 mg/kg were more potent than that of reference antidepressant fluoxetine. The extracts, at the dose of 140 mg/kg or above for 14 days, significantly inhibited the monoamine oxidize A (MAO) activity in mouse whole brain at a dose-dependent manner, however, oral administration of the extract only at a dose of 560 mg/kg produced observable MAO B inhibitory activity in animal brain. Fluoxetine showed only a tendency to inhibit MAO A and B activity in animal brain in the study. Neither the extracts of C. longa nor fluoxetine, at the doses tested, produced significant effects on locomotor activity. These results demonstrated that C. longa had specifically antidepressant effects in vivo. The activity of C. longa in antidepression may mediated in part through MAO A inhibition in mouse brain.


Asunto(s)
Antidepresivos/farmacología , Curcuma , Monoaminooxidasa/metabolismo , Fitoterapia , Extractos Vegetales/farmacología , Administración Oral , Animales , Antidepresivos/administración & dosificación , Antidepresivos/uso terapéutico , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Depresión/tratamiento farmacológico , Relación Dosis-Respuesta a Droga , Fluoxetina/administración & dosificación , Fluoxetina/farmacología , Fluoxetina/uso terapéutico , Masculino , Ratones , Ratones Endogámicos ICR , Mitocondrias/efectos de los fármacos , Mitocondrias/metabolismo , Actividad Motora/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico
9.
Chin Med J (Engl) ; 106(2): 145-8, 1993 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-8504698

RESUMEN

This paper deals with the ultrasonic studies of the effect of artemisia decoction (AD) on the volume and motion of gallbladder in 33 cases. Ultrasonic examination shows that AD intravenous infusion has remarkable effects on the contractility of gallbladder. There are 4 patterns of phasic changes in the motion of gallbladder and an increase in frequency of its contraction and relaxation. AD has also certain contraction effects on the gallbladders which can not contract after a fatty meal. The above findings indicate that AD is a good choleretic and has a definite regulating effect on the motility of the gallbladder. The clinical use of AD is conducive to bile flow, stone expelling, inhibiting the deposition of bile solids and reducing the possibility of stone formation.


Asunto(s)
Colagogos y Coleréticos/farmacología , Medicamentos Herbarios Chinos/farmacología , Vesícula Biliar/efectos de los fármacos , Vesícula Biliar/diagnóstico por imagen , Adolescente , Adulto , Niño , Femenino , Vesícula Biliar/fisiología , Humanos , Masculino , Persona de Mediana Edad , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Ultrasonografía
10.
Chin Med J (Engl) ; 104(8): 664-8, 1991 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-1914634

RESUMEN

Single or combined monoclonal antibodies (McAbs) Zh53, Zh820, and Zh2-1 have been used to eliminate malignant clonogenic cells from human bone marrow. The test of cytotoxicity showed that all of these McAbs could express high specific cytotoxic action against HL-60 cells and were selectively complement-dependent cytotoxic to various types of fresh leukemic cells. Clonogenic assay detected that single treatment with antibody and rabbit complement (RC) could reduce clonogenic units of HL-60 cells by more than 2 logs and two treatments reduced clonogenic units by more than 4 logs. However, combination of 2 McAbs could reduce clonogenic units by 4-5 logs. The data suggest that multiple treatments with McAbs and RC or a combination of 2 McAbs are more effective than a single treatment in eliminating clonogenic tumor cells. Treatment of normal human bone marrow with Zh53, Zh2-1 and RC did not produce a loss of normal CFU-GM, but treatment with Zh820 reduced the clonic units of normal CFU-GM by 24%.


Asunto(s)
Proteínas del Sistema Complemento/inmunología , Leucemia Mieloide/patología , Leucemia Promielocítica Aguda/patología , Animales , Anticuerpos Monoclonales , Anticuerpos Antineoplásicos/inmunología , Médula Ósea/patología , Ensayo de Unidades Formadoras de Colonias , Humanos , Leucemia Mieloide/inmunología , Leucemia Promielocítica Aguda/inmunología , Ratones , Conejos , Células Tumorales Cultivadas , Ensayo de Tumor de Célula Madre
11.
Sheng Li Xue Bao ; 49(1): 25-30, 1997 Feb.
Artículo en Zh | MEDLINE | ID: mdl-9812829

RESUMEN

After preincubation of crude synaptic membranes (P2 membranes) with phorber ester (PMA) or GABAB receptor agonist baclofen (BAL), the rate of inhibition of BAL on basal adenylate cyclase (AC) activity and forskolin-stimulated AC activity significantly reduced (desensitized). This effect of BAL did not change after preincubation with forskolin suggesting that the desensitization mechanism of GABAB receptor coupled AC is related with activation of protein kinase C (PKC), but not with protein kinase A. It was further found that the equilibrium dissociation constant (Kd) of GABAB receptor was increased during desensitization. Our results suggest that PKC activation may cause some structural or conformational changes of GABAB receptor, resulting in an uncoupling from G protein and desensitization of GABAB receptor-coupled AC.


Asunto(s)
Adenilil Ciclasas/metabolismo , Baclofeno/farmacología , Agonistas del GABA/farmacología , Receptores de GABA-B/metabolismo , Animales , Sitios de Unión/fisiología , Proteínas de Unión al GTP/metabolismo , Masculino , Ratones , Proteína Quinasa C/metabolismo , Membranas Sinápticas/metabolismo
12.
Yao Xue Xue Bao ; 31(11): 801-5, 1996.
Artículo en Zh | MEDLINE | ID: mdl-9863249

RESUMEN

In one trial passive avoidance response in mice, the effects of gamma-aminobutyric acid (GABA)B receptor agonist baclofen and antagonist CGP35348 and CGP36742 on acquisition, consolidation and retrieval of memory were observed. The results showed that the antagonists could significantly promote the acquisition impairment induced by baclofen, the consolidation impairment induced by baclofen and NaNO2, and the retrieval impairment induced by baclofen and 30% alcohol. These results suggest that the GABAB receptor antagonists may become a novel type of drug for the treatment of Alzheimer's disease.


Asunto(s)
Antagonistas del GABA/farmacología , Aprendizaje/efectos de los fármacos , Memoria/efectos de los fármacos , Compuestos Organofosforados/farmacología , Animales , Baclofeno/antagonistas & inhibidores , Baclofeno/farmacología , Femenino , Masculino , Ratones
13.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 13(10): 603-5, 581, 1993 Oct.
Artículo en Zh | MEDLINE | ID: mdl-8312697

RESUMEN

The present study includes 32 cases of sudden deafness treated with Sequential External Counterpulsation in addition to combined TCM-WM therapy, 30 cases treated with combined TCM-WM, and 30 cases treated with WM alone. The clinical findings of these 3 groups were quite similar, hence they were comparable. The mean duration of treatment, percentage of effectiveness and percentage of recurrence within 3 years were 13 days, 75% and 16.6% respectively in the first group; 19 days, 56.6% and 29.4% in the second group; and 21 days, 53.2% and 37.5% in the third group. The first group showed shorter duration of treatment higher effective rate and lower recurrence rate; and all their differences were statistically significant (P < 0.05). The data revealed that, the treatment of sudden deafness with Sequential External Counterpulsation in addition to combined TCM-WM has great advantage over treatment with combined TCM-WM or WM alone.


Asunto(s)
Contrapulsación , Medicamentos Herbarios Chinos/uso terapéutico , Pérdida Auditiva Súbita/terapia , Adenosina Trifosfato/uso terapéutico , Adolescente , Adulto , Anciano , Terapia Combinada , Femenino , Humanos , Lidocaína/uso terapéutico , Masculino , Persona de Mediana Edad , Extractos Vegetales , Salvia miltiorrhiza
14.
Zhongguo Zhong Yao Za Zhi ; 18(9): 566-7, 575, 1993 Sep.
Artículo en Zh | MEDLINE | ID: mdl-8011115

RESUMEN

The experiment shows that high concentration of Aster tataricus plus Glycyrrhiza uralensis Fisch. can inhibit the tracheal systoliea caused by histamine, but for tracheal systoliea caused by acetylcholine the inhibition is indistinct. The experiment also shows that Aster tataricus, glycyrrhiza uralensis and Tussilago far fara L. combined have coordinated inhibiting effect on the tracheal systoliea caused by histamine and acetylcholine.


Asunto(s)
Medicamentos Herbarios Chinos/farmacología , Glycyrrhiza , Músculo Liso/efectos de los fármacos , Plantas Medicinales , Acetilcolina/antagonistas & inhibidores , Animales , Sinergismo Farmacológico , Cobayas , Antagonistas de los Receptores Histamínicos/farmacología , Técnicas In Vitro , Masculino , Relajación Muscular/efectos de los fármacos , Tráquea/efectos de los fármacos
15.
J Int Med Res ; 40(6): 2213-9, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23321178

RESUMEN

OBJECTIVES: To compare surgical outcomes between transareola single-site endoscopic thyroidectomy (TASSET) and minimally invasive video-assisted thyroidectomy (MIVAT). METHODS: Patients with thyroid nodules were randomized to TASSET (n = 24) or MIVAT (n = 24). Surgical outcomes and patient-rated cosmetic results, based on numerical (0 [worst], 10 [best]) and verbal (1 [poor], 4 [excellent]) response scales, were compared. RESULTS: There were no significant differences between groups for age, sex, indication for operation, estimated blood loss, postoperative pain and length of postoperative stay. TASSET was associated with a significantly longer mean ± SD operative time than MIVAT (156.84 ± 41.42 vs. 66.38 ± 17.58 min), and significantly improved cosmetic results according to the numerical (9.63 ± 0.60 vs 7.90 ± 1.38) and verbal response (3.8 ± 0.5 vs 3.1 ± 0.7) scales. Postoperative complaints were comparable between the two approaches, although MIVAT involved a shorter operation time. CONCLUSIONS: Patients treated with TASSET had superior cosmetic results compared with those treated with MIVAT.


Asunto(s)
Endoscopía/métodos , Laparoscopía/métodos , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Tiroidectomía/métodos , Cirugía Asistida por Video/métodos , Adulto , Endoscopía/efectos adversos , Femenino , Humanos , Laparoscopía/efectos adversos , Masculino , Procedimientos Quirúrgicos Mínimamente Invasivos/efectos adversos , Dolor Postoperatorio , Complicaciones Posoperatorias , Nódulo Tiroideo/cirugía , Tiroidectomía/efectos adversos , Resultado del Tratamiento , Cirugía Asistida por Video/efectos adversos
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