Assuntos
Antipsicóticos/uso terapêutico , Transtornos Cognitivos/tratamento farmacológico , Diagnóstico por Imagem , Emoções/efeitos dos fármacos , Esquizofrenia/tratamento farmacológico , Psicologia do Esquizofrênico , Adolescente , Adulto , Antipsicóticos/efeitos adversos , Córtex Cerebral/efeitos dos fármacos , Córtex Cerebral/fisiopatologia , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/fisiopatologia , Antagonistas dos Receptores de Dopamina D2 , Eletroencefalografia , Emoções/fisiologia , Alucinações/diagnóstico , Alucinações/tratamento farmacológico , Alucinações/fisiopatologia , Humanos , Sistema Límbico/efeitos dos fármacos , Sistema Límbico/fisiopatologia , Receptores de Dopamina D2/fisiologia , Esquizofrenia/diagnóstico , Esquizofrenia/fisiopatologia , Linguagem do EsquizofrênicoRESUMO
OBJECTIVE: The authors' goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia. METHOD: Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed. RESULTS: The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects. CONCLUSIONS: These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia.