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1.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease.

Wang, Zixi; Zhu, Shijia; Jia, Yuemeng; Wang, Yunguan; Kubota, Naoto; Fujiwara, Naoto; Gordillo, Ruth; Lewis, Cheryl; Zhu, Min; Sharma, Tripti; Li, Lin; Zeng, Qiyu; Lin, Yu-Hsuan; Hsieh, Meng-Hsiung; Gopal, Purva; Wang, Tao; Hoare, Matt; Campbell, Peter; Hoshida, Yujin; Zhu, Hao.

Cell ; 186(9): 1968-1984.e20, 2023 04 27.

Article in English | MEDLINE | ID: mdl-37040760

2.

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

Wang, Xiaochen; He, Qifeng; Zhou, Chuanli; Xu, Yueyuan; Liu, Danhui; Fujiwara, Naoto; Kubota, Naoto; Click, Arielle; Henderson, Polly; Vancil, Janiece; Marquez, Cesia Ammi; Gunasekaran, Ganesh; Schwartz, Myron E; Tabrizian, Parissa; Sarpel, Umut; Fiel, Maria Isabel; Diao, Yarui; Sun, Beicheng; Hoshida, Yujin; Liang, Shuang; Zhong, Zhenyu.

Immunity ; 56(1): 58-77.e11, 2023 01 10.

Article in English | MEDLINE | ID: mdl-36521495

3.

Gut microbial carbohydrate metabolism contributes to insulin resistance.

Takeuchi, Tadashi; Kubota, Tetsuya; Nakanishi, Yumiko; Tsugawa, Hiroshi; Suda, Wataru; Kwon, Andrew Tae-Jun; Yazaki, Junshi; Ikeda, Kazutaka; Nemoto, Shino; Mochizuki, Yoshiki; Kitami, Toshimori; Yugi, Katsuyuki; Mizuno, Yoshiko; Yamamichi, Nobutake; Yamazaki, Tsutomu; Takamoto, Iseki; Kubota, Naoto; Kadowaki, Takashi; Arner, Erik; Carninci, Piero; Ohara, Osamu; Arita, Makoto; Hattori, Masahira; Koyasu, Shigeo; Ohno, Hiroshi.

Nature ; 621(7978): 389-395, 2023 Sep.

Article in English | MEDLINE | ID: mdl-37648852

4.

Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.

Toda, Gotaro; Soeda, Kotaro; Okazaki, Yukiko; Kobayashi, Naoki; Masuda, Yukari; Arakawa, Naoko; Suwanai, Hirotsugu; Masamoto, Yosuke; Izumida, Yoshihiko; Kamei, Nozomu; Sasako, Takayoshi; Suzuki, Ryo; Kubota, Tetsuya; Kubota, Naoto; Kurokawa, Mineo; Tobe, Kazuyuki; Noda, Tetsuo; Honda, Kenya; Accili, Domenico; Yamauchi, Toshimasa; Kadowaki, Takashi; Ueki, Kohjiro.

Mol Cell ; 79(1): 43-53.e4, 2020 07 02.

Article in English | MEDLINE | ID: mdl-32464093

5.

NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis.

Hiraike, Yuta; Saito, Kaede; Oguchi, Misato; Wada, Takahito; Toda, Gotaro; Tsutsumi, Shuichi; Bando, Kana; Sagawa, Junji; Nagano, Gaku; Ohno, Haruya; Kubota, Naoto; Kubota, Tetsuya; Aburatani, Hiroyuki; Kadowaki, Takashi; Waki, Hironori; Yanagimoto, Shintaro; Yamauchi, Toshimasa.

Proc Natl Acad Sci U S A ; 120(31): e2308750120, 2023 08.

Article in English | MEDLINE | ID: mdl-37487068

6.

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation.

Masamoto, Yosuke; Arai, Shunya; Sato, Tomohiko; Yoshimi, Akihide; Kubota, Naoto; Takamoto, Iseki; Iwakura, Yoichiro; Yoshimura, Akihiko; Kadowaki, Takashi; Kurokawa, Mineo.

Immunity ; 44(6): 1422-33, 2016 06 21.

Article in English | MEDLINE | ID: mdl-27317261

7.

Genetic Reduction of Insulin Signaling Mitigates Amyloid-ß Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.

Sano, Toshiharu; Ochiai, Toshitaka; Nagayama, Takeru; Nakamura, Ayaka; Kubota, Naoto; Kadowaki, Takashi; Wakabayashi, Tomoko; Iwatsubo, Takeshi.

J Neurosci ; 43(43): 7226-7241, 2023 10 25.

Article in English | MEDLINE | ID: mdl-37699718

8.

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids.

Zhu, Shijia; Kubota, Naoto; Hoshida, Yujin.

Trends Genet ; 37(5): 403-404, 2021 05.

Article in English | MEDLINE | ID: mdl-33541711

9.

A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.

Saito, Yoshinobu; Yin, Dingzi; Kubota, Naoto; Wang, Xiaobo; Filliol, Aveline; Remotti, Helen; Nair, Ajay; Fazlollahi, Ladan; Hoshida, Yujin; Tabas, Ira; Wangensteen, Kirk J; Schwabe, Robert F.

Gastroenterology ; 164(7): 1279-1292, 2023 06.

Article in English | MEDLINE | ID: mdl-36894036

10.

Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making.

Dhanasekaran, Renumathy; Suzuki, Hiroyuki; Lemaitre, Lea; Kubota, Naoto; Hoshida, Yujin.

Hepatology ; 2023 Jun 12.

Article in English | MEDLINE | ID: mdl-37300379

11.

Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development.

Qian, Tongqi; Fujiwara, Naoto; Koneru, Bhuvaneswari; Ono, Atsushi; Kubota, Naoto; Jajoriya, Arun K; Tung, Matthew G; Crouchet, Emilie; Song, Won-Min; Marquez, Cesia Ammi; Panda, Gayatri; Hoshida, Ayaka; Raman, Indu; Li, Quan-Zhen; Lewis, Cheryl; Yopp, Adam; Rich, Nicole E; Singal, Amit G; Nakagawa, Shigeki; Goossens, Nicolas; Higashi, Takaaki; Koh, Anna P; Bian, C Billie; Hoshida, Hiroki; Tabrizian, Parissa; Gunasekaran, Ganesh; Florman, Sander; Schwarz, Myron E; Hiotis, Spiros P; Nakahara, Takashi; Aikata, Hiroshi; Murakami, Eisuke; Beppu, Toru; Baba, Hideo; Bhatia, Sangeeta; Kobayashi, Masahiro; Kumada, Hiromitsu; Fobar, Austin J; Parikh, Neehar D; Marrero, Jorge A; Rwema, Steve Hategekimana; Nair, Venugopalan; Patel, Manishkumar; Kim-Schulze, Seunghee; Corey, Kathleen; O'Leary, Jacqueline G; Klintmalm, Goran B; Thomas, David L; Dibas, Mohammed; Rodriguez, Gerardo.

Gastroenterology ; 162(4): 1210-1225, 2022 04.

Article in English | MEDLINE | ID: mdl-34951993

12.

Diurnal changes in bacterial settlement on the Peyer's patch and surrounding mucosa in the rat ileum and its effect against the intestinal immune system.

Mantani, Youhei; Sakata, Nanami; Kubota, Naoto; Shimada, Asaka; Nakanishi, Satoki; Yokoyama, Toshifumi; Hoshi, Nobuhiko.

Cell Tissue Res ; 393(1): 83-95, 2023 Jul.

Article in English | MEDLINE | ID: mdl-37148397

13.

Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells.

Tatsuguchi, Takaaki; Uruno, Takehito; Sugiura, Yuki; Sakata, Daiji; Izumi, Yoshihiro; Sakurai, Tetsuya; Hattori, Yuko; Oki, Eiji; Kubota, Naoto; Nishimoto, Koshiro; Oyama, Masafumi; Kunimura, Kazufumi; Ohki, Takuto; Bamba, Takeshi; Tahara, Hideaki; Sakamoto, Michiie; Nakamura, Masafumi; Suematsu, Makoto; Fukui, Yoshinori.

Int Immunol ; 34(5): 277-289, 2022 04 20.

Article in English | MEDLINE | ID: mdl-35094065

14.

Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits.

Kubota, Naoto; Suyama, Mikita.

PLoS Comput Biol ; 18(8): e1010436, 2022 08.

Article in English | MEDLINE | ID: mdl-36037215

15.

Cooperation between artificial intelligence and endoscopists for diagnosing invasion depth of early gastric cancer.

Goto, Atsushi; Kubota, Naoto; Nishikawa, Jun; Ogawa, Ryo; Hamabe, Koichi; Hashimoto, Shinichi; Ogihara, Hiroyuki; Hamamoto, Yoshihiko; Yanai, Hideo; Miura, Osamu; Takami, Taro.

Gastric Cancer ; 26(1): 116-122, 2023 01.

Article in English | MEDLINE | ID: mdl-36040575

16.

LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.

Ishihama, Sohta; Yoshida, Satoya; Yoshida, Tatsuya; Mori, Yu; Ouchi, Noriyuki; Eguchi, Shunsuke; Sakaguchi, Teruhiro; Tsuda, Takuma; Kato, Katsuhiro; Shimizu, Yuuki; Ohashi, Koji; Okumura, Takahiro; Bando, Yasuko K; Yagyu, Hiroaki; Wettschureck, Nina; Kubota, Naoto; Offermanns, Stefan; Kadowaki, Takashi; Murohara, Toyoaki; Takefuji, Mikito.

FASEB J ; 35(12): e22048, 2021 12.

Article in English | MEDLINE | ID: mdl-34807469

17.

SnapShot: Insulin signaling pathways.

Kadowaki, Takashi; Ueki, Kohjiro; Yamauchi, Toshimasa; Kubota, Naoto.

Cell ; 148(3): 624, 624.e1, 2012 Feb 03.

Article in English | MEDLINE | ID: mdl-22304926

18.

SnapShot: physiology of insulin signaling.

Kadowaki, Takashi; Kubota, Naoto; Ueki, Kohjiro; Yamauchi, Toshimasa.

Cell ; 148(4): 834-834.e1, 2012 Feb 17.

Article in English | MEDLINE | ID: mdl-22341452

19.

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.

Fujii, Tomohiro; Nishikawa, Jun; Fukuda, Soichiro; Kubota, Naoto; Nojima, Junzo; Fujisawa, Koichi; Ogawa, Ryo; Goto, Atsushi; Hamabe, Koichi; Hashimoto, Shinichi; Wai, Aung Phyo; Iizasa, Hisashi; Yoshiyama, Hironori; Sakai, Kohei; Suehiro, Yutaka; Yamasaki, Takahiro; Takami, Taro.

Int J Mol Sci ; 23(18)2022 Sep 13.

Article in English | MEDLINE | ID: mdl-36142506

20.

LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover.

Tanaka, Yuki; Shimanaka, Yuta; Caddeo, Andrea; Kubo, Takuya; Mao, Yanli; Kubota, Tetsuya; Kubota, Naoto; Yamauchi, Toshimasa; Mancina, Rosellina Margherita; Baselli, Guido; Luukkonen, Panu; Pihlajamäki, Jussi; Yki-Järvinen, Hannele; Valenti, Luca; Arai, Hiroyuki; Romeo, Stefano; Kono, Nozomu.

Gut ; 70(1): 180-193, 2021 01.

Article in English | MEDLINE | ID: mdl-32253259

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