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Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.

Haemmig, Stefan; Hashemi Gheinani, Ali; Zaromytidou, Marina; Siasos, Gerasimos; Coskun, Ahmet Umit; Cormier, Michelle A; Gross, David A; Wara, A K M Khyrul; Antoniadis, Antonios P; Sun, Xinghui; Sukhova, Galina K; Welt, Fred G P; Andreou, Ioannis; Whatling, Carl; Gan, Li-Ming; Wikström, Johannes; Edelman, Elazer R; Libby, Peter; Stone, Peter H; Feinberg, Mark W.

Arterioscler Thromb Vasc Biol ; 41(4): 1487-1503, 2021 04.

Article in English | MEDLINE | ID: mdl-33567868

ABSTRACT

[Figure: see text].

Subject(s)

Carotid Artery Diseases/genetics , Coronary Artery Disease/genetics , Diabetes Mellitus, Type 2/genetics , Gene Expression Profiling , Plaque, Atherosclerotic , Transcriptome , Aged , Aged, 80 and over , Animals , Carotid Artery Diseases/metabolism , Carotid Artery Diseases/pathology , Coronary Artery Disease/metabolism , Coronary Artery Disease/pathology , Diabetes Mellitus, Experimental/diagnosis , Diabetes Mellitus, Experimental/genetics , Diabetes Mellitus, Experimental/metabolism , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/metabolism , Disease Progression , Female , Gene Expression Regulation , Gene Regulatory Networks , Humans , Hypercholesterolemia/genetics , Hypercholesterolemia/metabolism , Machine Learning , Male , Middle Aged , RNA-Seq , Severity of Illness Index , Signal Transduction , Sus scrofa

ABSTRACT

Subject(s)

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