RESUMEN
ALK rearrangements define a histopathologically distinctive yet diverse subset of Spitz tumors characterized by fusiform to epithelioid melanocytes with frequent fascicular growth and ALK overexpression. Molecularly, these tumors are characterized by fusions between ALK and a variety of gene partners, most commonly TPM3 and DCTN1. We describe an unusual case of a Spitz nevus occurring in a 13-year-old female that manifested ALK immunopositivity with cell membrane localization. The proliferation was polypoid and composed of elongated nests of epithelioid melanocytes with enlarged nuclei, prominent nucleoli, and abundant cytoplasm without significant atypia and lacking mitotic figures. The nevus exhibited strong and diffuse expression of p16. Targeted next-generation RNA sequencing revealed an in-frame EHBP1-ALK fusion, which has been reported only once in the literature. EHBP1 encodes an adaptor protein with plasma membrane targeting potential. Together, these findings suggest that the 5' ALK fusion partner in Spitz tumors may dictate the subcellular localization of the ALK chimeric oncoprotein. In summary, this case highlights a rare ALK fusion associated with a distinct immunohistochemical staining pattern and further expands the spectrum of ALK-rearranged melanocytic tumors.
Asunto(s)
Quinasa de Linfoma Anaplásico/metabolismo , Proteínas Portadoras/metabolismo , Nevo de Células Epitelioides y Fusiformes , Nevo Pigmentado , Neoplasias Cutáneas , Adolescente , Quinasa de Linfoma Anaplásico/genética , Femenino , Fusión Génica , Humanos , Nevo de Células Epitelioides y Fusiformes/genética , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/patologíaRESUMEN
BACKGROUND: Pityriasis lichenoides (PL) is a papulosquamous disease that affects both adults and children. Previous studies have shown a subset of this entity to have clonal T-cell populations via PCR-based assays. In this study, we sought to implement next-generation sequencing (NGS) as a more sensitive and specific test to examine for T-cell clonality within the pediatric population. METHODS: We identified 18 biopsy specimens from 12 pediatric patients with clinical and histopathologic findings compatible with PL. Patient demographics, clinical features, management, and histopathologic findings were reviewed. All specimens were analyzed for clonality with NGS of T-cell receptor beta (TRB) and gamma (TRG) genes. RESULTS: Of the 12 patients, 9 (75%) had complete resolution of lesions at the time of data collection (mean follow-up 31 months). The remaining three patients significantly improved with methotrexate (with or without acitretin). Interestingly, 7 of 12 patients (58%) and 9 of 17 biopsy specimens (53%) showed evidence of T-cell clonality. Two patients showed matching TRB clones from different anatomic sites. CONCLUSIONS: T-cell clonality is a common finding in PL, probably representing a "reactive clonality" rather than a true lymphoproliferative disorder. Clonality alone cannot be used as a means to distinguish PL from lymphomatoid papulosis or cutaneous lymphoma.
Asunto(s)
Clonación Molecular , Genes Codificadores de la Cadena beta de los Receptores de Linfocito T/genética , Genes Codificadores de la Cadena gamma de los Receptores de Linfocito T/genética , Pitiriasis Liquenoide/genética , Adolescente , Niño , Preescolar , Femenino , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , MasculinoRESUMEN
Accurate classification of soft tissue neoplasms of the skin and subcutis can be challenging given the sometimes significant histomorphologic and immunohistochemical overlap between the entities that comprise this ever-expanding category of tumors. With the benefit of continually emerging adjuncts to histologic diagnosis, pathologists have a number of tools at their disposal for navigating this group of neoplasms. This article aims to review recent immunohistochemical and molecular updates in the diagnosis of cutaneous soft tissue neoplasms.
Asunto(s)
Neoplasias Cutáneas , Neoplasias de los Tejidos Blandos , Humanos , Inmunohistoquímica , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias de los Tejidos Blandos/diagnóstico , Neoplasias de los Tejidos Blandos/patologíaRESUMEN
Nodular fasciitis is a benign, self-limited, pseudosarcomatous neoplasm that can mimic malignancy due to its rapid growth, cellularity, and mitotic activity. Involvement of the breast is rare and diagnosis on biopsy can be challenging. In this largest series to date, we examined the clinicopathologic and molecular characteristics of 12 cases of nodular fasciitis involving the breast/axilla. All patients were female, with a median age of 32 years (range 15-61). The lesions were 0.4 to 5.8 cm in size (median 0.8). All cases presented as palpable masses, and two patients had overlying skin retraction. Microscopically, lesions were relatively well-circumscribed nodular masses of bland myofibroblastic spindle cells within a variably myxoid stroma. Infiltrative growth into adipose tissue or breast epithelium was frequent. Mitotic figures were present in all cases, ranging from 1 to 12 per 10 high-power fields (median 3). Immunohistochemically, all cases expressed smooth muscle actin and were negative for pan-cytokeratin, p63, desmin, CD34, and nuclear beta-catenin. Targeted RNA sequencing performed on 11 cases identified USP6 gene fusions in eight; one additional case was positive by break-apart fluorescence in situ hybridization. The common MYH9-USP6 rearrangement was detected in four cases; another case had a rare alternative fusion with CTNNB1. Three cases harbored novel USP6 gene fusions involving NACA, SLFN11, or LDHA. All fusions juxtaposed the promoter region of the 5' partner gene with the full-length coding sequence of USP6. Outcome data were available for eight patients; none developed recurrence or metastasis. Five patients elected for observation without immediate excision, and self-resolution of the lesions was reported in three cases. Albeit uncommon, nodular fasciitis should be considered in the differential diagnosis of breast spindle cell lesions. A broad immunohistochemical panel to exclude histologic mimics, including metaplastic carcinoma, is important. Confirmatory detection of USP6 rearrangements can aid in classification, with potential therapeutic implications.
Asunto(s)
Neoplasias de la Mama/patología , Fascitis/patología , Fusión de Oncogenes/genética , Ubiquitina Tiolesterasa/genética , Adolescente , Adulto , Neoplasias de la Mama/genética , Fascitis/genética , Femenino , Humanos , Persona de Mediana Edad , Adulto JovenRESUMEN
Fibromatoses encompass a broad group of histopathologically similar fibroblastic/myofibroblastic proliferations with divergent clinical manifestations and behavior. Deep (desmoid-type) fibromatoses are typically large, rapidly growing, and locally aggressive tumors that occur in the abdominal wall, mesentery, and extra-abdominal soft tissue, principally the musculature of the trunk and extremities. Most sporadic cases of desmoid fibromatosis harbor inactivating mutations in CTNNB1, the gene encoding beta-catenin. Tumors occurring in the context of familial adenomatous polyposis and Gardner syndrome bear inactivating mutations in APC. By contrast, mutations in CTNNB1 or APC have not been identified in cases of superficial fibromatosis. Cutaneous involvement by desmoid fibromatosis is exceedingly rare. Here we present a 78-year-old male with desmoid-type fibromatosis arising in the dermis of the right medial calf with a pathogenic mutation in CTNNB1 and a variant of unknown significance in APC.
Asunto(s)
Poliposis Adenomatosa del Colon/patología , Dermis/patología , Fibromatosis Agresiva/diagnóstico , Síndrome de Gardner/patología , Poliposis Adenomatosa del Colon/genética , Proteína de la Poliposis Adenomatosa del Colon , Anciano , Diagnóstico Diferencial , Fibromatosis Agresiva/genética , Fibromatosis Agresiva/cirugía , Síndrome de Gardner/genética , Humanos , Masculino , Mutación , Resultado del Tratamiento , beta Catenina/metabolismoRESUMEN
Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3-year-old female with an ALK-positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip.
Asunto(s)
Quinasa de Linfoma Anaplásico/genética , Nevo de Células Epitelioides y Fusiformes/patología , Neoplasias Cutáneas/patología , Preescolar , Femenino , Humanos , Labio/patología , Mutación , Nevo de Células Epitelioides y Fusiformes/genética , Nervios Periféricos/patología , Neoplasias Cutáneas/genéticaRESUMEN
ABSTRACT: Atypical fibroxanthoma (AFX) is a neoplasm that most commonly occurs on sun-damaged skin of the head and neck in elderly patients and that usually exhibits indolent clinical behavior with complete excision. The granular cell variant of AFX demonstrates overlapping histopathologic features with dermal non-neural granular cell tumor (NNGCT), which typically arises on the extremities of young to middle aged adults with rare reports of regional metastasis. A subset of NNGCT harbors ALK rearrangements and expresses ALK by immunohistochemistry. Here, we present 2 cases of granular cell AFX occurring on the scalp of males aged 73 and 87 with ALK expression by immunohistochemistry and no evidence of an ALK rearrangement on fluorescence in situ hybridization, representing a diagnostic pitfall for NNGCT.
Asunto(s)
Quinasa de Linfoma Anaplásico/metabolismo , Tumor de Células Granulares/metabolismo , Neoplasias de Cabeza y Cuello/metabolismo , Cuero Cabelludo , Neoplasias Cutáneas/metabolismo , Xantomatosis/metabolismo , Anciano , Anciano de 80 o más Años , Quinasa de Linfoma Anaplásico/genética , Reordenamiento Génico , Tumor de Células Granulares/genética , Tumor de Células Granulares/patología , Neoplasias de Cabeza y Cuello/genética , Neoplasias de Cabeza y Cuello/patología , Humanos , Inmunohistoquímica , Masculino , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/patología , Xantomatosis/patologíaRESUMEN
Cutaneous tuberculosis is an uncommon entity with several clinical forms recognized. Histopathologically, most cases are characterized by granulomatous inflammation and caseating necrosis, although less common findings, including vasculitis, have also been described. We report a 55-year-old male with a history of recently diagnosed dermatomyositis receiving immunosuppression with mycophenolate mofetil and prednisone, who developed multifocal soft tissue abscesses and an indurated erythematous plaque on the back. Skin biopsy of the back revealed a necrotizing medium-vessel vasculitis. Mycobacterium tuberculosis was detected in the skin via acid-fast bacilli stain and confirmed by tissue culture and polymerase chain reaction. Cutaneous findings improved rapidly with antituberculosis therapy. This case illustrates an uncommon clinical and histopathologic presentation of disseminated tuberculosis.
Asunto(s)
Dermatomiositis/complicaciones , Piel/microbiología , Infecciones de los Tejidos Blandos/patología , Tuberculosis Cutánea/diagnóstico , Vasculitis/patología , Absceso/diagnóstico , Antituberculosos/uso terapéutico , Biopsia , Dermatomiositis/tratamiento farmacológico , Diagnóstico Diferencial , Estudios de Seguimiento , Humanos , Huésped Inmunocomprometido , Terapia de Inmunosupresión/efectos adversos , Masculino , Persona de Mediana Edad , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/aislamiento & purificación , Piel/patología , Infecciones de los Tejidos Blandos/diagnóstico , Infecciones de los Tejidos Blandos/microbiología , Resultado del Tratamiento , Tuberculosis Cutánea/tratamiento farmacológico , Tuberculosis Cutánea/patologíaRESUMEN
Pleomorphic fibromas are rare benign cutaneous neoplasms associated with deletion/loss of chromosomes 13q and 17p, where RB1 and TP53 are located, respectively. Herein, we report five cases of pleomorphic fibroma arising in patients with germline TP53 mutations, suggesting a potential link with Li-Fraumeni syndrome. All three patients were female and young (mean age 27) with a strong personal and/or family oncologic history and confirmed pathogenic germline TP53 mutations. In two patients, multiple pleomorphic fibromas were diagnosed. Clinically, the lesions arose at various cutaneous sites and were small (≤2 cm) and raised (4/5). Histopathologically, the tumors were paucicellular, composed of atypical spindled to stellate cells with hyperchromatic and variably pleomorphic nuclei. Mitotic activity was exceedingly low, although rare atypical mitotic figures were seen in one case. Immunohistochemically, the tumor cells were diffusely positive for p16 (3/3) and showed loss of Rb expression (5/5). All cases showed aberrant p53 expression (overexpression in 4, complete loss in 1). The tumors have followed a benign clinical course with no evidence of progression or recurrence. In conclusion, the development of multiple pleomorphic fibromas in a young patient may be a clue to an underlying genetic cancer syndrome involving TP53.
Asunto(s)
Fibroma/diagnóstico , Células Germinativas/metabolismo , Síndrome de Li-Fraumeni/genética , Neoplasias de Tejido Fibroso/patología , Neoplasias Cutáneas/patología , Proteína p53 Supresora de Tumor/metabolismo , Adulto , Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo , Femenino , Fibroma/metabolismo , Fibroma/radioterapia , Fibroma/cirugía , Estudios de Seguimiento , Predisposición Genética a la Enfermedad , Células Germinativas/patología , Mutación de Línea Germinal/genética , Humanos , Inmunohistoquímica/métodos , Síndrome de Li-Fraumeni/diagnóstico , Síndrome de Li-Fraumeni/patología , Mutación Missense , Neoplasias de Tejido Fibroso/metabolismo , Radioterapia Adyuvante/métodos , Proteína de Retinoblastoma/metabolismo , Neoplasias Cutáneas/metabolismo , Resultado del TratamientoRESUMEN
BACKGROUND: PRAME (PReferentially expressed Antigen in MElanoma) has shown utility in distinguishing melanoma from benign melanocytic lesions, but knowledge of its expression pattern in intermediate melanocytic and spitzoid proliferations is limited. METHODS: Immunohistochemical expression of PRAME was examined in 112 melanocytic proliferations with intermediate histopathologic or spitzoid features. RESULTS: Any intensity of nuclear PRAME staining in at least 60% of lesional melanocytes was determined as the best threshold for diffuse staining in this cohort. Nearly all non-spitzoid melanomas (23/24; 95.8%) demonstrated diffuse PRAME expression. PRAME was completely negative in 95.6% (43/45) of mitotically-active nevi, traumatized nevi, nevi with persistent/recurrent features, and dysplastic nevi. Most Spitz nevi (15/20) and atypical Spitz tumors (10/13) entirely lacked PRAME expression. One Spitz nevus, one atypical Spitz tumor, and one spitzoid melanoma (1/2) demonstrated diffuse PRAME expression. CONCLUSIONS: Although diffuse PRAME expression is generally limited to malignant melanoma, benign Spitz nevi and atypical Spitz tumors can infrequently express diffuse PRAME. PRAME immunohistochemistry can be useful in the evaluation of atypical melanocytic proliferations with intermediate histopathologic features but should be interpreted with caution in the setting of spitzoid neoplasms.
Asunto(s)
Antígenos de Neoplasias/genética , Proliferación Celular/genética , Melanocitos/patología , Melanoma/genética , Neoplasias Cutáneas/genética , Adulto , Anciano , Proteínas Portadoras/genética , Estudios de Cohortes , Diagnóstico Diferencial , Síndrome del Nevo Displásico/genética , Síndrome del Nevo Displásico/patología , Femenino , Humanos , Inmunohistoquímica/métodos , Masculino , Melanoma/patología , Nevo de Células Epitelioides y Fusiformes/genética , Nevo de Células Epitelioides y Fusiformes/patología , Neoplasias Cutáneas/patología , Proteínas Supresoras de Tumor/genética , Ubiquitina Tiolesterasa/genética , Melanoma Cutáneo MalignoRESUMEN
Primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid is a rare and aggressive neoplasm. Fewer than 50 cases have been reported in the literature, and the genetic driving mutations are unknown. Herein, we present a case of this rare disease along with the results of molecular profiling via targeted next-generation sequencing. The patient is an 85-year-old man who presented with left eyelid swelling initially thought to be a chalazion. After no response to incision and drainage and antibiotics, an incisional biopsy was performed. Histopathologic sections revealed a proliferation of cells with signet-ring and histiocytoid morphology arranged singly and in cords infiltrating the dermis, subcutaneous tissue, and muscle. The lesional cells strongly expressed cytoplasmic cytokeratin 7 and nuclear androgen receptor. Next-generation sequencing revealed a CDH1 mutation, which is known to confer signet-ring morphology in other carcinomas. Pathogenic mutations in NTRK3, CDKN1B, and PIK3CA were also detected. To our knowledge, this is the first documented genetic analysis of this rare disease with findings that offer insights into disease pathogenesis and potential therapeutic targets.
Asunto(s)
Antígenos CD/genética , Cadherinas/genética , Carcinoma de Células en Anillo de Sello/genética , Neoplasias de los Párpados/genética , Queratina-7/metabolismo , Receptores Androgénicos/metabolismo , Anciano de 80 o más Años , Antineoplásicos Hormonales/uso terapéutico , Biopsia , Carcinoma de Células en Anillo de Sello/diagnóstico , Carcinoma de Células en Anillo de Sello/terapia , Terapia Combinada , Neoplasias de los Párpados/patología , Secuenciación de Nucleótidos de Alto Rendimiento/métodos , Histiocitos/patología , Humanos , Masculino , Mutación , Radioterapia Adyuvante/métodos , Neoplasias Cutáneas/patología , Colgajos Quirúrgicos , Resultado del TratamientoRESUMEN
Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations. In this study, we demonstrate that expression of ZBTB46 identifies human dendritic cell neoplasms. We examined ZBTB46 expression in a range of benign and malignant histiocytic disorders and found that ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes. In particular, all examined cases of Langerhans cell histiocytosis and histiocytic sarcoma expressed ZBTB46, while all cases of blastic plasmacytoid dendritic cell neoplasm, chronic myelomonocytic leukemia, juvenile xanthogranuloma, Rosai-Dorfman disease, and Erdheim-Chester disease failed to demonstrate expression of ZBTB46. Moreover, ZBTB46 expression clarified the identity of diagnostically challenging neoplasms, such as cases of indeterminate cell histiocytosis, classifying a fraction of these entities as dendritic cell malignancies. These findings clarify the lineage origins of human histiocytic disorders and distinguish dendritic cell disorders from all other myeloid neoplasms.
Asunto(s)
Células Dendríticas/metabolismo , Histiocitosis/diagnóstico , Células Mieloides/metabolismo , Factores de Transcripción/metabolismo , Adolescente , Adulto , Anciano , Niño , Preescolar , Células Dendríticas/patología , Diagnóstico Diferencial , Femenino , Histiocitosis/metabolismo , Histiocitosis/patología , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Células Mieloides/patología , Adulto JovenAsunto(s)
Quinasas Janus/metabolismo , Linfoma de Células T/metabolismo , Factores de Transcripción STAT/metabolismo , Transducción de Señal , Antineoplásicos/farmacología , Antineoplásicos/uso terapéutico , Humanos , Quinasas Janus/genética , Linfoma de Células T/tratamiento farmacológico , Linfoma de Células T/genética , Terapia Molecular Dirigida , Mutación/efectos de los fármacos , Factores de Transcripción STAT/genética , Transducción de Señal/efectos de los fármacosRESUMEN
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms.
Asunto(s)
Antígeno Ki-1/metabolismo , Linfoma Anaplásico de Células Grandes , Proteínas de Neoplasias/metabolismo , Neoplasias Cutáneas , Animales , Humanos , Linfoma Anaplásico de Células Grandes/diagnóstico , Linfoma Anaplásico de Células Grandes/metabolismo , Linfoma Anaplásico de Células Grandes/patología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patologíaAsunto(s)
Carcinoma de Células Escamosas/genética , Proteínas de Unión al ADN/genética , Sarcoma/genética , Factores de Transcripción/genética , Anciano de 80 o más Años , Biopsia/métodos , Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Genes p53/genética , Humanos , Inmunohistoquímica/métodos , Queratosis Actínica/patología , Masculino , Sarcoma/diagnóstico , Neoplasias Cutáneas/patologíaAsunto(s)
Miofibroma/genética , Receptor beta de Factor de Crecimiento Derivado de Plaquetas/genética , Esclerodermia Localizada/complicaciones , Administración Oral , Adulto , Biopsia/métodos , Enfermedades del Tejido Conjuntivo/patología , Fármacos Dermatológicos/administración & dosificación , Fármacos Dermatológicos/uso terapéutico , Femenino , Secuenciación de Nucleótidos de Alto Rendimiento/métodos , Humanos , Metotrexato/administración & dosificación , Metotrexato/uso terapéutico , Mutación , Miofibroma/complicaciones , Miofibroma/diagnóstico , Miofibroma/tratamiento farmacológico , Esclerodermia Localizada/diagnóstico , Esclerodermia Localizada/tratamiento farmacológico , Neoplasias Cutáneas/patología , Resultado del TratamientoAsunto(s)
Adenocarcinoma , Artritis , Neoplasias Pancreáticas , Paniculitis , Adenocarcinoma/complicaciones , Adenocarcinoma/diagnóstico , Anciano , Artritis/diagnóstico , Artritis/etiología , Humanos , Masculino , Neoplasias Pancreáticas/complicaciones , Neoplasias Pancreáticas/diagnóstico , Paniculitis/diagnóstico , Paniculitis/etiologíaAsunto(s)
Mejilla/patología , Histiocitosis de Células no Langerhans/diagnóstico , Proteínas Proto-Oncogénicas c-raf/genética , Proteína 2 del Complejo de la Esclerosis Tuberosa/genética , Anciano , Alelos , Biopsia , Secuenciación de Nucleótidos de Alto Rendimiento/métodos , Histiocitosis de Células no Langerhans/metabolismo , Histiocitosis de Células no Langerhans/cirugía , Humanos , Inmunohistoquímica/métodos , Masculino , MutaciónAsunto(s)
Antígenos de Neoplasias/biosíntesis , Melanoma/diagnóstico , Sarcoma de Células Claras/diagnóstico , Neoplasias Cutáneas/diagnóstico , Antígenos de Neoplasias/análisis , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/metabolismo , Diagnóstico Diferencial , Humanos , Sensibilidad y Especificidad , Melanoma Cutáneo MalignoRESUMEN
Rash is one of the commonly observed adverse events with brentuximab vedotin (BV), a CD30-targeted antibody-drug conjugate used to treat cutaneous T-cell lymphoma (CTCL). However, clinical and histopathologic characterization of BV-associated rash (BVAR) is limited. Distinguishing BVAR from a patient's underlying CTCL can be challenging and can lead to treatment interruptions or even premature drug discontinuation. We performed a thorough clinical and histopathologic retrospective characterization of BVAR from a single institution. Utilizing polymerase chain reaction (PCR) and T-cell receptor high-throughput sequencing (TCR-HTS), we were able to isolate skin biopsy specimens from rash clinically suggestive of BVAR that also lacked a dominant TCR clone. A retrospective evaluation was performed of 26 biopsy specimens from 14 patients. Clinical features of BVAR included predominantly morbilliform or maculopapular morphology, delayed onset, and the trend toward moderate to severe classification, often requiring oral steroids. Most histopathologic specimens (25/26) showed spongiotic dermatitis as the primary reaction pattern. Many cases showed subtle findings to support a background interface or lichenoid eruption. Langerhans cell microabscesses were seen in one-fourth of specimens, and eosinophils were present in over one-half of the specimens. There were focal features mimicking CTCL, but these were not prominent. In 17 specimens with immunohistochemistry, the CD4:CD8 ratio in intraepidermal lymphocytes was relatively normal (1-6:1) in 65% (11/17) and 1:1 in 35% (6/17), demonstrating a trend toward increased CD8-positive cells compared with baseline CTCL. We have identified features that can help distinguish BVAR from a patient's CTCL, which can, in turn, help guide appropriate clinical management.