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1.
Lack of Effect of Cenerimod, a Selective S1P1 Receptor Modulator, on the Pharmacokinetics of a Combined Oral Contraceptive.
Int J Mol Sci
; 23(23)2022 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36499313
2.
PK/PD modeling of a clazosentan thorough QT study with hysteresis in concentration-QT and RR-QT.
J Pharmacokinet Pharmacodyn
; 48(2): 213-224, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33389549
3.
Modelling pharmacokinetics and pharmacodynamics of the selective S1P1 receptor modulator cenerimod in healthy subjects and systemic lupus erythematosus patients.
Br J Clin Pharmacol
; 86(4): 791-800, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31756016
4.
Cardiodynamic Interactions between Two S1P1 Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects.
Int J Mol Sci
; 20(13)2019 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31266149
5.
A pharmacokinetic drug-drug interaction study between selexipag and midazolam, a CYP3A4 substrate, in healthy male subjects.
Eur J Clin Pharmacol
; 73(9): 1121-1128, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28639119
6.
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects.
Int J Mol Sci
; 18(12)2017 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211013
7.
Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation.
Eur J Neurosci
; 44(3): 1952-62, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27285721
8.
Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons.
Eur J Neurosci
; 41(3): 390-7, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25427854
9.
Long-lasting spinal oxytocin analgesia is ensured by the stimulation of allopregnanolone synthesis which potentiates GABA(A) receptor-mediated synaptic inhibition.
J Neurosci
; 33(42): 16617-26, 2013 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-24133265
10.
Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-ß monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors.
J Immunother Cancer
; 11(11)2023 11 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38030303
11.
Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody.
Leukemia
; 37(6): 1349-1360, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37024520
12.
Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P1 R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects.
Clin Transl Sci
; 14(1): 143-147, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860737
13.
Insights from In Vitro and Clinical Data to Guide Transition from the Novel P2Y12 Antagonist Selatogrel to Clopidogrel, Prasugrel, and Ticagrelor.
Thromb Haemost
; 121(6): 755-766, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33412611
14.
Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm.
Front Pharmacol
; 11: 628956, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33613288
15.
Association Between Vomiting and QT Hysteresis: Data from a TQT Study with the Endothelin A Receptor Antagonist Clazosentan.
AAPS J
; 22(5): 103, 2020 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32748293
16.
First use of cenerimod, a selective S1P1 receptor modulator, for the treatment of SLE: a double-blind, randomised, placebo-controlled, proof-of-concept study.
Lupus Sci Med
; 6(1): e000354, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31798918
17.
Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan.
Clin Transl Sci
; 12(5): 440-444, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31004470
18.
Clinical Pharmacology of the Reversible and Potent P2Y12 Receptor Antagonist ACT-246475 After Single Subcutaneous Administration in Healthy Male Subjects.
J Clin Pharmacol
; 59(1): 123-130, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30088663
19.
Accelerated Development of the Dual Orexin Receptor Antagonist ACT-541468: Integration of a Microtracer in a First-in-Human Study.
Clin Pharmacol Ther
; 104(5): 1022-1029, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29446069
20.
Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation.
Pain
; 159(12): 2630-2640, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30169420