Detalhe da pesquisa
1.
Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody.
Blood
; 138(25): 2655-2669, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34280257
2.
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.
Biol Chem
; 403(5-6): 495-508, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35073465
3.
Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins.
J Biol Chem
; 292(38): 15622-15635, 2017 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28751378
4.
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.
J Biol Chem
; 291(31): 16292-306, 2016 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226599
5.
Mapping the conformational space accessible to catechol-O-methyltransferase.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 8): 2163-74, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25084335
6.
Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.
Proc Natl Acad Sci U S A
; 108(31): 12669-74, 2011 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21768335
7.
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.
J Med Chem
; 67(3): 1758-1782, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38241614
8.
Structure of gentlyase, the neutral metalloprotease of Paenibacillus polymyxa.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 1): 24-31, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23275160
9.
The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 9): 1826-38, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999306
10.
Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 6): 1124-37, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23695257
11.
BACE1 inhibitors: a head group scan on a series of amides.
Bioorg Med Chem Lett
; 23(14): 4239-43, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735744
12.
Scintillation Proximity Assay (SPA)-Based Radioligand Binding for PPARα, PPARγ, and PPARδ Receptors.
Methods Mol Biol
; 2576: 145-153, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36152183
13.
Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Cofactor Recruitment Assay for PPARα and PPARγ.
Methods Mol Biol
; 2576: 155-169, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36152184
14.
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water.
Chemistry
; 18(1): 213-22, 2012 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22162109
15.
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
PLoS One
; 17(9): e0268590, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36084029
16.
Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging.
J Med Chem
; 65(3): 2191-2207, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35089028
17.
Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.
Nucl Med Biol
; 108-109: 24-32, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35248850
18.
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Bioorg Med Chem Lett
; 21(11): 3237-42, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21550236
19.
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Bioorg Med Chem Lett
; 20(17): 5313-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20650636
20.
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Bioorg Med Chem Lett
; 20(2): 594-9, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969452