Detalhe da pesquisa
1.
Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and procyclidine: implications of the delivery system for the potential application against VX nerve agent intoxication in humans.
Arch Toxicol
; 97(3): 697-710, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633609
2.
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Cell Mol Life Sci
; 78(1): 207-225, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32140747
3.
Effect of treatment period with LC478, a disubstituted adamantayl derivative, on P-glycoprotein inhibition: its application to increase docetaxel absorption in rats.
Xenobiotica
; 50(7): 863-874, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31791185
4.
Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry.
Molecules
; 25(3)2020 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991809
5.
Suppression of Canine ATP Binding Cassette ABCB1 in Madin-Darby Canine Kidney Type II Cells Unmasks Human ABCG2-Mediated Efflux of Olaparib.
J Pharmacol Exp Ther
; 368(1): 79-87, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30396915
6.
Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo.
Planta Med
; 85(9-10): 719-728, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31137047
7.
Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2-Mediated Interaction in Hepatic Transport.
Drug Metab Dispos
; 45(3): 246-259, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28069721
8.
Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats.
J Sep Sci
; 40(19): 3782-3791, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28749011
9.
High body clearance and low oral bioavailability of alantolactone, isolated from Inula helenium, in rats: extensive hepatic metabolism and low stability in gastrointestinal fluids.
Biopharm Drug Dispos
; 37(3): 156-67, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26861967
10.
Metabolic interactions of magnolol with cytochrome P450 enzymes: uncompetitive inhibition of CYP1A and competitive inhibition of CYP2C.
Drug Dev Ind Pharm
; 42(2): 263-9, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26133083
11.
Gender differences in the hepatic elimination and pharmacokinetics of lobeglitazone in rats.
Biopharm Drug Dispos
; 36(6): 410-415, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25899769
12.
In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism.
Planta Med
; 80(7): 561-7, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24710899
13.
AAPE proliposomes for topical atopic dermatitis treatment.
J Microencapsul
; 31(8): 768-73, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25090594
14.
Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice.
Front Pharmacol
; 15: 1352842, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38590637
15.
Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug.
Xenobiotica
; 43(4): 355-67, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23020787
16.
The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin.
Xenobiotica
; 43(7): 579-91, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23252722
17.
Prediction of the Time to Reach Equilibrium for Improved Estimation of the Unbound Fraction of Compounds in Equilibrium Dialysis Using kinetic Modeling.
J Pharm Sci
; 112(11): 2901-2909, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37392902
18.
Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)2D3-treated Caco-2 cells.
Eur J Pharm Sci
; 183: 106396, 2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36736464
19.
Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans.
Pharmaceutics
; 15(3)2023 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986803
20.
Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: its application for head and neck cancer treatment.
Pharm Res
; 29(4): 1007-19, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169985